High-color-purity, high-brightness and angle-insensitive red structural color

We propose a simple five-layer structure for creating red structural color, which has high color purity and high brightness.The design is based on the superposition of a silver substrate and multilayer silicon material. Absorption at the shorter wavelengths of the structure is effectively guaranteed, and reflection at the longer wavelengths is well enhanced. The red structural color has a peak reflectivity of 91% and a colorimetric purity of 0.9. Moreover, the designed structure displays angle-invariant performance up to 60°. This kind of structure scheme is environmentally friendly with low fabrication cost,and it can play an important role in a variety of fields, such as color displays and image sensors.

Regular diet is non-inferior to restricted diet after polypectomy with decreased hospitalization length of stay and cost:a randomized–controlled trial

Background There are no data comparing a regular diet with a restricted diet after endoscopic polypectomy in patients with colorectal polyps.The current guidelines also did not provide the detailed information of dietary patterns after polypectomy.In this study,we aimed to evaluate the safety and efficacy of different diets on post-polypectomy outcomes.Methods A total of 302 patients with colorectal polyps who underwent polypectomy were prospectively enrolled between March 2019 and December 2019 in Nanfang Hospital(Guangzhou,China).Enrolled patients were then randomly assigned to a regular diet group or a restricted diet group after polypectomy.The study is a non-inferior design and the primary end point was the post-operative adverse events(AE)rate.Secondary end points included length of stay(LOS)and hospitalization cost.Results Among all the included patients,148 patients received a restricted diet and 154 patients received a regular diet after polypectomy.A total of 376 polyps were removed,with 183 polyps in the restricted diet group and 193 polyps in the regular diet group.Shorter LOS(4.0±1.4 vs 4.8±1.7,P<0.001)and lower hospitalization costs(7,701.63±2,579.07 vs 8,656.05±3,138.53,P=0.001)were observed in the regular diet group.In particular,there was no significant difference in 3-day AE rates between the restricted diet and the regular diet group(1.35%[2/148]vs 2.60%[4/154],P=0.685).Subgroup analysis looking at the number of polyps removed in each patient and different treatmentmodalities also showed similar findings.Conclusion Regular diet should be recommended after polypectomy for polyps<20mm as it can shorten LOS and save hospitalization costs.

Nanoparticle delivery for central nervous system diseases and its clinical application

In the treatment of central nervous system(CNS)diseases such as glioma,Alzheimer's disease(AD)and Parkinson's disease(PD),drugs are expected to reach specific areas of the brain to achieve the desired effect.Although a growing number of therapeutic targets have been identified in preclinical studies,the ones that can ultimately be used in the clinic are limited.Therefore,the research process and clinical application of drugs for treating CNS diseases are still large challenges.Physiological barriers such as the blood‒brain barrier(BBB)act as selective permeable membranes,allowing only certain molecules to enter the brain;this barrier is the major obstacle restricting the arrival of most drugs to brain lesions.Recently,nanoparticles,including lipid-based,cell-derived biomimetic,polymeric and inorganic nanoparticles,have gained increasing attention because of their ability to cross physiological barriers,and could play an important role as delivery carriers and immunomodulators.Additionally,clinical applications of nanoparticles in CNS diseases are underway.This review focuses on the progress of current research on the use of nanoparticles for the treatment of CNS diseases to provide additional insight into the treatment of CNS diseases.