Time-Domain Dual Component Computation Diversity Based on Generalized Hybrid Carrier

In this paper,the concept of computation diversity is proposed by employing generalized hybrid carrier(GHC)system.The signal is backed up by transform-domain computation to enhance the anti-fading capability.Theoretical analysis is presented to demonstrate the superiority of the proposed method.Numerical simulations in doubly-selective fading channels are provided to verify the results.The bit error rate(BER)performance is guaranteed with a small computational complexity increment.The proposed method not only extends the new diversity dimension,but also improves the diversity gain of the system without occupying additional wireless resources.Moreover,the proposed method shows good adaptability with single carrier modulation and improves diversity performance.As the simulation results shown,time-domain dual component computation diversity(TDC-CD)has 1d B BER gain and 0.1diversity gain at high signal-to-noise ratio,and single carrier system with TDC-CD achieves 2d B BER gain at 10~(-4).

Erratum to"HLA-E-restricted Hantaan virus-specific CD8^(+)T cell responses enhance the control of infection in hemorrhagic fever with renal syndrome"[Biosaf.Health 5(2023)289-299]

The publisher regrets that during proofreading of the figure legend of Fig.6,the P value was misspelled in the sentence"while"n.s."indicates no significant difference P<0.05".It should be corrected to""while"n.s."indicates no significant difference(P>0.05)".

HLA-E-restricted Hantaan virus-specific CD8^(+)T cell responses enhance the control of infection in hemorrhagic fever with renal syndrome

Infection with the Hantaan virus(HTNV)may result in severe hemorrhagic fever with renal syndrome(HFRS).The functions of HLA-E-restricted CD8^(+)T lymphocytes in virus control and vaccine development have recently received increased attention.The purpose of this research is to discover HLA-E-restricted CD8^(+)T cell epitopes on HTNV as well as the features of these epitope-specific CD8^(+)T cells in HFRS patients.To anticipate HLA-Erestricted HTNV epitopes,the NetMHCpan servers were utilized.The K562/HLA-E cell binding test and the enzyme-linked immunospot assay were used to confirm epitope binding to HLA-E.The number and features of HLA-E-restricted epitope-specific CD8^(+)T lymphocytes in HFRS patients were investigated using tetramer staining,intracellular cytokine labeling,proliferation,and cytotoxicity assays.Six HTNV-derived HLA-Erestricted CD8^(+)T cell epitopes were found in this study.In mild/moderate HFRS patients,the frequency of HLA-E-restricted epitope-specific CD8^(+)T cells was greater than in severe/critical patients.CD38+HLA-DR+HLA-E-restricted CD8^(+)T cells were identified.Meanwhile,CD45RA^(+)CCR7^(-)effector memory-re-expressing CD45RA T cells with early and intermediate maturation and differentiation characteristics predominated.Notably,CD8^(+)T cells from milder HFRS patients produced more interferon-γ,interleukin-2,and granzyme B,had a stronger proliferative potential,and were inversely linked with the amount of plasma HTNV virus load.Furthermore,HLA-E-restricted epitope-specific CD8^(+)T cells demonstrated improved cytotoxic activity in vitro during the acute stage of HFRS.Taken together,the findings demonstrate the protective effects of HLA-E-restricted CD8^(+)T cells during HTNV infection,suggesting that HLA-E-targeted vaccines against HTNV might be developed for HLA-diverse populations.

High-order compact finite volume methods on unstructured grids with adaptive mesh refinement for solving inviscid and viscous flows

In the present paper, high-order finite volume schemes on unstructured grids developed in our previous papers are extended to solve three-dimensional inviscid and viscous flows. The highorder variational reconstruction technique in terms of compact stencil is improved to reduce local condition numbers. To further improve the efficiency of computation, the adaptive mesh refinement technique is implemented in the framework of high-order finite volume methods. Mesh refinement and coarsening criteria are chosen to be the indicators for certain flow structures. One important challenge of the adaptive mesh refinement technique on unstructured grids is the dynamic load balancing in parallel computation. To solve this problem, the open-source library p4 est based on the forest of octrees is adopted. Several two-and three-dimensional test cases are computed to verify the accuracy and robustness of the proposed numerical schemes.