Total Electron Content(TEC)and electron density enhancement were observed on the day before 17 March 2015 great storm in the China Region.Observations from ground-and space-based instruments are used to investigate th...Total Electron Content(TEC)and electron density enhancement were observed on the day before 17 March 2015 great storm in the China Region.Observations from ground-and space-based instruments are used to investigate the temporal and spatial evolution of the pre-storm enhancement.TEC enhancement was observed from 24°N to 30°N after 10:00 UT at 105°E,110°E and 115°E longitudes on March 16.The maximum magnitude of TEC enhancement was more than 10 TECU and the maximal relative TEC enhancement exceeded 30%.Compared with geomagnetic quiet days,the electron density of Equatorial Ionization Anomaly(EIA)northern peak from Swarm A/C satellites on March 16 was larger and at higher latitudes.NmF2 enhanced during 11:30—21:00 UT at Shaoyang Station and increased by 200%at~16:00 UT.However,TEC and electron density enhancement were not accompanied by a significant change of hmF2.Most research has excluded some potential mechanisms as the main driving factors for storm-time density enhancements by establishing observational constraints.In this paper,we observed pre-storm enhancement in electron density at different altitudes and Equatorial Electrojet(EEJ)strength results derived from ground magnetometers observations suggest an enhanced eastward electric field from the E region probably played a significant role in this event.展开更多
During a long-term Equatorial Plasma Bubbles(EPBs)occurrence between October 2020 and March 2021,a significant EPB suppression event was identified on November 22 and the observations from multi-instrument have been u...During a long-term Equatorial Plasma Bubbles(EPBs)occurrence between October 2020 and March 2021,a significant EPB suppression event was identified on November 22 and the observations from multi-instrument have been utilized to investigate this event.Global-scale Observations of the Limb and Disk(GOLD)satellite observed prominent EPBs between 23:40 UT and 23:55 UT during the long-term occurrence days.However,no dark stripes representing EPBs were observed on November 22,and the Equatorial Ionization Anomaly(EIA)structure remained intact.The Total Electron Content(TEC)maps show that these EPBs appeared in the region between 35°W and 65°W longitudes and the magnitudes of the TEC loss in EPBs regions were about 20 TECU.Except for 22 November,the S4 index was consistently greater than 0.6 throughout November,indicating significant ionospheric scintillation.The Rate Of TEC Index(ROTI)maps revealed that the spatial extent and intensity of EPBs increased after their suppression,and the EPBs were locally generated.The swarm electron density measurements indicated that the variation amplitudes of EPBs at 510 km altitude were approximately 3 to 5 times larger than that at 460 km altitude.The impact region of EPBs at 510 km was between 15°S and 20°N latitudes,while at 460 km,it was between 0°and 17°N latitudes.During the period of EPB suppression,the average h’f at three ionosonde stations decreased by about 50 km,and the vertical drift velocity(V z)approached~0 m/s while it was more than 20 m/s during the long-term occurrence.展开更多
Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and inflammation.Mitochondria regulate macrophage activation and innate immun...Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and inflammation.Mitochondria regulate macrophage activation and innate immune responses in various inflammatory diseases,including cochlear inflammation.The distribution,number,and morphological characteristics of cochlear macrophages change significantly across different inner ear regions under various pathological conditions,including noise exposure,ototoxicity,and age-related degeneration.However,the exact mechanism underlying the role of mitochondria in macrophages in auditory function remains unclear.Here,we summarize the major factors and mitochondrial signaling pathways(e.g.,metabolism,mitochondrial reactive oxygen species,mitochondrial DNA,and the inflammasome)that influence macrophage activation in the innate immune response.In particular,we focus on the properties of cochlear macrophages,activated signaling pathways,and the secretion of inflammatory cytokines after acoustic injury.We hope this review will provide new perspectives and a basis for future research on cochlear inflammation.展开更多
Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum...Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.展开更多
基金Fundamental Research Funds for the Central Universities(No.B230201012)National Natural Science Foundation of China(No.42104009)China Postdoctoral Science Foundation(No.2022M720988)。
文摘Total Electron Content(TEC)and electron density enhancement were observed on the day before 17 March 2015 great storm in the China Region.Observations from ground-and space-based instruments are used to investigate the temporal and spatial evolution of the pre-storm enhancement.TEC enhancement was observed from 24°N to 30°N after 10:00 UT at 105°E,110°E and 115°E longitudes on March 16.The maximum magnitude of TEC enhancement was more than 10 TECU and the maximal relative TEC enhancement exceeded 30%.Compared with geomagnetic quiet days,the electron density of Equatorial Ionization Anomaly(EIA)northern peak from Swarm A/C satellites on March 16 was larger and at higher latitudes.NmF2 enhanced during 11:30—21:00 UT at Shaoyang Station and increased by 200%at~16:00 UT.However,TEC and electron density enhancement were not accompanied by a significant change of hmF2.Most research has excluded some potential mechanisms as the main driving factors for storm-time density enhancements by establishing observational constraints.In this paper,we observed pre-storm enhancement in electron density at different altitudes and Equatorial Electrojet(EEJ)strength results derived from ground magnetometers observations suggest an enhanced eastward electric field from the E region probably played a significant role in this event.
基金National Natural Science Foundation of China(No.42104009)China Postdoctoral Science Foundation(No.2022M720988)Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX22_0663)。
文摘During a long-term Equatorial Plasma Bubbles(EPBs)occurrence between October 2020 and March 2021,a significant EPB suppression event was identified on November 22 and the observations from multi-instrument have been utilized to investigate this event.Global-scale Observations of the Limb and Disk(GOLD)satellite observed prominent EPBs between 23:40 UT and 23:55 UT during the long-term occurrence days.However,no dark stripes representing EPBs were observed on November 22,and the Equatorial Ionization Anomaly(EIA)structure remained intact.The Total Electron Content(TEC)maps show that these EPBs appeared in the region between 35°W and 65°W longitudes and the magnitudes of the TEC loss in EPBs regions were about 20 TECU.Except for 22 November,the S4 index was consistently greater than 0.6 throughout November,indicating significant ionospheric scintillation.The Rate Of TEC Index(ROTI)maps revealed that the spatial extent and intensity of EPBs increased after their suppression,and the EPBs were locally generated.The swarm electron density measurements indicated that the variation amplitudes of EPBs at 510 km altitude were approximately 3 to 5 times larger than that at 460 km altitude.The impact region of EPBs at 510 km was between 15°S and 20°N latitudes,while at 460 km,it was between 0°and 17°N latitudes.During the period of EPB suppression,the average h’f at three ionosonde stations decreased by about 50 km,and the vertical drift velocity(V z)approached~0 m/s while it was more than 20 m/s during the long-term occurrence.
基金supported by the China Postdoctoral Science Foundation(2022M712892)the Joint project Henan Province Medical Science and Technology Project(LHGJ20210297).
文摘Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and inflammation.Mitochondria regulate macrophage activation and innate immune responses in various inflammatory diseases,including cochlear inflammation.The distribution,number,and morphological characteristics of cochlear macrophages change significantly across different inner ear regions under various pathological conditions,including noise exposure,ototoxicity,and age-related degeneration.However,the exact mechanism underlying the role of mitochondria in macrophages in auditory function remains unclear.Here,we summarize the major factors and mitochondrial signaling pathways(e.g.,metabolism,mitochondrial reactive oxygen species,mitochondrial DNA,and the inflammasome)that influence macrophage activation in the innate immune response.In particular,we focus on the properties of cochlear macrophages,activated signaling pathways,and the secretion of inflammatory cytokines after acoustic injury.We hope this review will provide new perspectives and a basis for future research on cochlear inflammation.
基金supported by the National Natural Science Foundation of China(31730036,31871380,31871382,31930055,31930058,32000500,32022034,32030033,32070730,32130046,3217050247,32150005,32200595,32222024,81730019,81730022,81830014,81921006,81925005,81970426,81971301,81971312,82030041,82061160495,82070805,82071595,82090020,82100841,82120108009,82122024,82125002,82125011,82125012,82130045,82171284,82173061,82173398,82225007,82225015,82225017,82225018,82230047,82230088,82271600,91949106,91949201,92049116,92049302,92049304,92149303,92149306,92157202,92168201,92169102,92249301,92268201)the National Key Research and Development Program of China(2018YFA0800700,2018YFC2000100,2018YFC2000102,2018YFC2002003,2019YFA0110900,2019YFA0801703,2019YFA0801903,2019YFA0802202,2019YFA0904800,2020YFA0113400,2020YFA0803401,2020YFA0804000,2020YFC2002900,2020YFC2008000,2020YFE0202200,2021YFA0804900,2021YFA1100103,2021YFA1100900,2021YFE0114200,2021ZD0202400,2022YFA0806001,2022YFA0806002,2022YFA0806600,2022YFA1103200,2022YFA1103601,2022YFA1103701,2022YFA1103800,2022YFA1103801,2022YFA1104100,2022YFA1104904,2022YFA1303000,2022YFC2009900,2022YFC2502401,2022YFC3602400,2022YFE0118000,2022ZD0213200)+14 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030302,XDB39000000,XDB39030600)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2020085,2021080)CAS Project for Young Scientists in Basic Research(YSBR-076)the Program of the Beijing Natural Science Foundation(JQ20031)Clinical Research Operating Fund of Central High level hospitals(2022-PUMCHE-001)CAMS Innovation Fund for Medical Sciences(CIFMS)(2022-I2M1-004)Talent Program of the Chinese Academy of Medical Science(2022RC310-10)Research Funds from Health@Inno HK Program launched by Innovation Technology Commission of the Hong Kong Special Administrative Region,Guangdong Basic and Applied Basic Research Foundation(2020B1515020044)Guangzhou Planned Project of Science and Technology(202002020039)the Major Technology Innovation of Hubei Province(2019ACA141)the Science and Technology Major Project of Hunan Provincial Science and Technology Department(2021SK1010)Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)the Natural Science Foundation of Sichuan Province(2023NSFSC0003)Yunnan Fundamental Research Project(202201AS070080)the State Key Laboratory of Membrane Biology。
文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.