Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest,and has been recognized as a potential breakthrough in overcoming t...Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest,and has been recognized as a potential breakthrough in overcoming the challenges of conventional oncotherapy.Nanoparticles are ideal candidates as carriers for theranostic agents,which is attributed to their extraordinary physicochemical properties,including nanoscale sizes,functional properties,prolonged blood circulation,active or passive tumor targeting,specific cellular uptake,and in some cases,excellent optical properties that ideally meet the needs of phototherapy and imaging at the same time.Overall,with the development of nanotechnology,theranostics has become a reality,and is now in the transition stage of"bench to bedside."In this review,we summarize recent progress on nanotechnology-based theranostics,i.e.,nanotheranostics,that has greatly assisted traditional therapies,and has provided therapeutic strategies emerging in recent decades,as well as"cocktail"theranostics mixing various treatment modalities.展开更多
In this paper,a novel dual flux modulation(DFM)machine with consequent-pole spoke-array permanent magnets(PMs)in both stator and rotor is proposed to achieve a larger torque density than regular flux modulation machin...In this paper,a novel dual flux modulation(DFM)machine with consequent-pole spoke-array permanent magnets(PMs)in both stator and rotor is proposed to achieve a larger torque density than regular flux modulation machines.The stator has two portions of PMs,one is set next to the stator slot with circumferential magnetization,and the other is inserted between the stator yoke and flux bridge with radial magnetization.The rotor has consequent-pole spoke-array PMs and alternative flux bridges.The proposed DFMPM machine can be regarded as the combination of the flux switching PM(FSPM)machine and vernier PM(VPM)machine.First,the structure and operational principle are introduced.Then,the proposed 12-stator-slot/10-rotor-tooth dual flux modulation permanent magnet(DFMPM)machine is compared with the FSPM machine and VPM machine in terms of flux lines distribution,back-electromotive force(EMF),cogging torque and average torque.Finally,the four proposed DFMPM machines are optimized for maximum average torque and minimum ripple torque considering the effects of split ratio,slot opening ratio,PM depth,PM angle and iron angle.展开更多
Poly （ADP-ribose） polymerase-1 （PARP-1） can exacerbate ischemic brain injury and lessen ischemic neuronal death, which may be associated with PARP-1 polymorphisms. The present study investigated human PARP-1 gene ...Poly （ADP-ribose） polymerase-1 （PARP-1） can exacerbate ischemic brain injury and lessen ischemic neuronal death, which may be associated with PARP-1 polymorphisms. The present study investigated human PARP-1 gene polymorphisms in various Chinese nationalities, the results of which could potentially help in the treatment and prevention of neurologic diseases. Genetic polymorphisms of seven exons in the PARP-1 gene, in 898 Chinese Han, Buyi, Shui, Miao, and Zhuang subjects, were investigated by PCR-single-strand conformation polymorphism. A single-strand conformation polymorphism variant in exons 12, 13, 16, and 17 of the PARP-1 gene was identified in 148 people, with two stationary bands showing three degenerative single strands. Results showed that the PARP-1 gene polymorphisms exist in various nationalities, and may act as a biomarker for susceptibility to disease.展开更多
In this paper[1],Figure 5(a)is mistakenly used with the figure of ground truth,which is taken and stitched by 10×/0.3NA objective and the operations have been detailed in the main text.The correction is as follow...In this paper[1],Figure 5(a)is mistakenly used with the figure of ground truth,which is taken and stitched by 10×/0.3NA objective and the operations have been detailed in the main text.The correction is as follows(Figure 1).This error does not affect the conclusion of this paper.The authors have also checked other figures such as Figure 6,and they are used correctly.展开更多
Solar photocatalysis,as a method of green energy production and sustainable technology,has been regarded as one of the most effective strategies to resolve environmental issues and the current energy crisis.In this wo...Solar photocatalysis,as a method of green energy production and sustainable technology,has been regarded as one of the most effective strategies to resolve environmental issues and the current energy crisis.In this work,intimate contact hollow Ni_(x)Co_(1-x)S polyhedron/g-C3N4 nanosheet composites were prepared in-situ through a facile one-step hydrothermal method.The as-prepared Ni_(x)Co_(1-x)S/g-C_(3)N_(4) composites showed superior photocatalytic activity and high stability for H2 generation and methyl orange(MO)degradation under visible light irradiation.The optimized 4 wt.%Ni_(x)Co_(1-x)S/g-C_(3)N_(4) composite attained a maximum H2 evolution rate of 1420μmol g^–1 h^–1,which was about 157 times higher than that of pure g-C3N4.In addition,the Ni_(x)Co_(1-x)S/g-C_(3)N_(4) composite also exhibited greatly improved photocatalytic activity for dye degradation,which for MO was at 98.14%in 9 min.The outstanding photocatalytic performance was predominantly attributed to the unique architecture of hollow Ni_(x)Co_(1-x)S polyhedrons,which not only provided more active sites at the edges and surface as convenient charge transfer channels,but also promoted the separation and transport of electron-hole pairs.This work provides some novel ideas for the design and development of highly efficient noble metal-free cocatalyst/semiconductor systems for photocatalytic H2 generation and dye degradation.展开更多
An improved hybrid method combining two dimensional(2D)finite element analysis(FEA)and the analytical method is put forward to calculate the stator winding inductance and synchronous inductance influenced by stator sk...An improved hybrid method combining two dimensional(2D)finite element analysis(FEA)and the analytical method is put forward to calculate the stator winding inductance and synchronous inductance influenced by stator skewing technique.Based on winding function theory(WFT),the improved method proposes two factors to describe variable inductances along the stator skewing angles.Comprehensive simulations are then performed on three interior permanent magnet synchronous machines(IPMSMs),one normal and two skewed machines(half slot and one slot pitch skewing respectively).Extensive experiments are conducted on relevant prototypes with good correlation.Moreover,analysis and comparisons are made as to the influence of different skewing angles on the inductances and torque-speed curves.It is found that Ld increases and Lq decreases by skewing,leading to the reduction of the rotor saliency and maximal torque capability,but increase of the flux weakening capability.展开更多
The usage of full-color imaging in digital pathology produces significant results.Compared with a grayscale image or a pseudocolor image containing contrast information,a full-color image can identify and detect the t...The usage of full-color imaging in digital pathology produces significant results.Compared with a grayscale image or a pseudocolor image containing contrast information,a full-color image can identify and detect the target object better with color texture information.Fourier ptychographic microscopy(FPM)is a high-throughput computational imaging technique that breaks the tradeoff between high resolution(HR)and a large field of view.It also eliminates the artifacts of scanning and stitching in digital pathology and improves its imaging efficiency.However,the conventional full-color digital pathology based on FPM is still time-consuming because of the repeated experiments with tri-wavelengths.A color transfer FPM approach termed“CFPM”was reported.The color texture information of a low-resolution full-color pathologic image is directly transferred to the HR grayscale FPM image captured by only a single wavelength.Both of the color space of FPM based on the standard CIE-XYZ color model and the display based on the standard RGB color space were established.Different FPM colorization schemes were analyzed and compared with 30 biological samples.Three types of evaluation approaches were provided,including the root-mean-square error(RMSE),the difference maps,and the image histogram cosine similarity.The average RMSE values of the conventional method and CFPM compared with the ground truth were 5.3%and 5.7%,respectively.Therefore,the reconstruction time is significantly reduced by 2/3 with the sacrifice of precision of only 0.4%.The CFPM method is also compatible with advanced fast FPM approaches to further reduce computation time.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.22077038 and 21702070)the National Basic Research Plan of China(Grant No.2018YFA0208903)+2 种基金the Postdoctoral Research Foundation of China(Grant No.2017M612461)the National Undergraduate Program for Innovation and Entrepreneurship of China(Grant No.19YA06)the Shenzhen Science and Technology Project(Grant No.JCYJ20170818161I36779)。
文摘Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest,and has been recognized as a potential breakthrough in overcoming the challenges of conventional oncotherapy.Nanoparticles are ideal candidates as carriers for theranostic agents,which is attributed to their extraordinary physicochemical properties,including nanoscale sizes,functional properties,prolonged blood circulation,active or passive tumor targeting,specific cellular uptake,and in some cases,excellent optical properties that ideally meet the needs of phototherapy and imaging at the same time.Overall,with the development of nanotechnology,theranostics has become a reality,and is now in the transition stage of"bench to bedside."In this review,we summarize recent progress on nanotechnology-based theranostics,i.e.,nanotheranostics,that has greatly assisted traditional therapies,and has provided therapeutic strategies emerging in recent decades,as well as"cocktail"theranostics mixing various treatment modalities.
基金This work was supported by National Natural Science Foundation of China(NSFC)under Project Number 51520105010 and 51607079。
文摘In this paper,a novel dual flux modulation(DFM)machine with consequent-pole spoke-array permanent magnets(PMs)in both stator and rotor is proposed to achieve a larger torque density than regular flux modulation machines.The stator has two portions of PMs,one is set next to the stator slot with circumferential magnetization,and the other is inserted between the stator yoke and flux bridge with radial magnetization.The rotor has consequent-pole spoke-array PMs and alternative flux bridges.The proposed DFMPM machine can be regarded as the combination of the flux switching PM(FSPM)machine and vernier PM(VPM)machine.First,the structure and operational principle are introduced.Then,the proposed 12-stator-slot/10-rotor-tooth dual flux modulation permanent magnet(DFMPM)machine is compared with the FSPM machine and VPM machine in terms of flux lines distribution,back-electromotive force(EMF),cogging torque and average torque.Finally,the four proposed DFMPM machines are optimized for maximum average torque and minimum ripple torque considering the effects of split ratio,slot opening ratio,PM depth,PM angle and iron angle.
基金the National Natural Science Foundation of China, No. 30972500the Natural Science Foundation of Guangdong Province, No. 7301507
文摘Poly （ADP-ribose） polymerase-1 （PARP-1） can exacerbate ischemic brain injury and lessen ischemic neuronal death, which may be associated with PARP-1 polymorphisms. The present study investigated human PARP-1 gene polymorphisms in various Chinese nationalities, the results of which could potentially help in the treatment and prevention of neurologic diseases. Genetic polymorphisms of seven exons in the PARP-1 gene, in 898 Chinese Han, Buyi, Shui, Miao, and Zhuang subjects, were investigated by PCR-single-strand conformation polymorphism. A single-strand conformation polymorphism variant in exons 12, 13, 16, and 17 of the PARP-1 gene was identified in 148 people, with two stationary bands showing three degenerative single strands. Results showed that the PARP-1 gene polymorphisms exist in various nationalities, and may act as a biomarker for susceptibility to disease.
文摘In this paper[1],Figure 5(a)is mistakenly used with the figure of ground truth,which is taken and stitched by 10×/0.3NA objective and the operations have been detailed in the main text.The correction is as follows(Figure 1).This error does not affect the conclusion of this paper.The authors have also checked other figures such as Figure 6,and they are used correctly.
基金financially supported by the National Natural Science Foundation of China(No.21801091)the Science Technology Development Planning of Jilin Province(No.20190103117JH)the Education Department Project of Jilin Province(Nos.JJKH20200242KJ and JJKH20190827KJ)。
文摘Solar photocatalysis,as a method of green energy production and sustainable technology,has been regarded as one of the most effective strategies to resolve environmental issues and the current energy crisis.In this work,intimate contact hollow Ni_(x)Co_(1-x)S polyhedron/g-C3N4 nanosheet composites were prepared in-situ through a facile one-step hydrothermal method.The as-prepared Ni_(x)Co_(1-x)S/g-C_(3)N_(4) composites showed superior photocatalytic activity and high stability for H2 generation and methyl orange(MO)degradation under visible light irradiation.The optimized 4 wt.%Ni_(x)Co_(1-x)S/g-C_(3)N_(4) composite attained a maximum H2 evolution rate of 1420μmol g^–1 h^–1,which was about 157 times higher than that of pure g-C3N4.In addition,the Ni_(x)Co_(1-x)S/g-C_(3)N_(4) composite also exhibited greatly improved photocatalytic activity for dye degradation,which for MO was at 98.14%in 9 min.The outstanding photocatalytic performance was predominantly attributed to the unique architecture of hollow Ni_(x)Co_(1-x)S polyhedrons,which not only provided more active sites at the edges and surface as convenient charge transfer channels,but also promoted the separation and transport of electron-hole pairs.This work provides some novel ideas for the design and development of highly efficient noble metal-free cocatalyst/semiconductor systems for photocatalytic H2 generation and dye degradation.
基金National Natural Science Foundation of China under Grant 51520105010.
文摘An improved hybrid method combining two dimensional(2D)finite element analysis(FEA)and the analytical method is put forward to calculate the stator winding inductance and synchronous inductance influenced by stator skewing technique.Based on winding function theory(WFT),the improved method proposes two factors to describe variable inductances along the stator skewing angles.Comprehensive simulations are then performed on three interior permanent magnet synchronous machines(IPMSMs),one normal and two skewed machines(half slot and one slot pitch skewing respectively).Extensive experiments are conducted on relevant prototypes with good correlation.Moreover,analysis and comparisons are made as to the influence of different skewing angles on the inductances and torque-speed curves.It is found that Ld increases and Lq decreases by skewing,leading to the reduction of the rotor saliency and maximal torque capability,but increase of the flux weakening capability.
基金This work was supported by the National Natural Science Foundation of China(Grant No.81427802).
文摘The usage of full-color imaging in digital pathology produces significant results.Compared with a grayscale image or a pseudocolor image containing contrast information,a full-color image can identify and detect the target object better with color texture information.Fourier ptychographic microscopy(FPM)is a high-throughput computational imaging technique that breaks the tradeoff between high resolution(HR)and a large field of view.It also eliminates the artifacts of scanning and stitching in digital pathology and improves its imaging efficiency.However,the conventional full-color digital pathology based on FPM is still time-consuming because of the repeated experiments with tri-wavelengths.A color transfer FPM approach termed“CFPM”was reported.The color texture information of a low-resolution full-color pathologic image is directly transferred to the HR grayscale FPM image captured by only a single wavelength.Both of the color space of FPM based on the standard CIE-XYZ color model and the display based on the standard RGB color space were established.Different FPM colorization schemes were analyzed and compared with 30 biological samples.Three types of evaluation approaches were provided,including the root-mean-square error(RMSE),the difference maps,and the image histogram cosine similarity.The average RMSE values of the conventional method and CFPM compared with the ground truth were 5.3%and 5.7%,respectively.Therefore,the reconstruction time is significantly reduced by 2/3 with the sacrifice of precision of only 0.4%.The CFPM method is also compatible with advanced fast FPM approaches to further reduce computation time.
