With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides(miPs), a kind of small polypeptides. ...With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides(miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial function.MiPs are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications.展开更多
The photothermoelectric(PTE)effect enables a simple structure to construct a noncontact and self-powered writing device.PTE detectors based on active materials and one-dimensional(1D)position-sensitive PTE effect have...The photothermoelectric(PTE)effect enables a simple structure to construct a noncontact and self-powered writing device.PTE detectors based on active materials and one-dimensional(1D)position-sensitive PTE effect have attracted considerable attentions.However,there is no research on applying the 1D position-sensitive PTE effect to a two-dimensional(2D)surface.Besides,flexible writing devices based on the PTE effect have not been reported.Here,we demonstrate a self-powered flexible optical writing device based on the 2D position-sensitive PTE effect of SnSe thin film.Laser positioning,tracking,and distinguishing of optically written characters have been realized by only measuring the bi-directional output voltages during the writing process.A deep convolutional neural network has been introduced to recognize optically written numbers and characters with high recognition accuracy(92%)and fast processing speed(8.6 ms).The flexible optical-writing device with a simple structure could rapidly and accurately recognize characters in a noncontact fashion using a small amount of training data.展开更多
基金supported by the National Natural Science Foundation of China(No.81870237)。
文摘With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides(miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial function.MiPs are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications.
基金supported by the Basic Science Center Project of NSFC(51788104)the National Natural Science Foundation of China(52172046).
文摘The photothermoelectric(PTE)effect enables a simple structure to construct a noncontact and self-powered writing device.PTE detectors based on active materials and one-dimensional(1D)position-sensitive PTE effect have attracted considerable attentions.However,there is no research on applying the 1D position-sensitive PTE effect to a two-dimensional(2D)surface.Besides,flexible writing devices based on the PTE effect have not been reported.Here,we demonstrate a self-powered flexible optical writing device based on the 2D position-sensitive PTE effect of SnSe thin film.Laser positioning,tracking,and distinguishing of optically written characters have been realized by only measuring the bi-directional output voltages during the writing process.A deep convolutional neural network has been introduced to recognize optically written numbers and characters with high recognition accuracy(92%)and fast processing speed(8.6 ms).The flexible optical-writing device with a simple structure could rapidly and accurately recognize characters in a noncontact fashion using a small amount of training data.
