A new staggered isolated system developed from the mid-story isolated system is the new staggered story isolated system. There are not many studies on this structure currently. In this study, an 18-story new staggered...A new staggered isolated system developed from the mid-story isolated system is the new staggered story isolated system. There are not many studies on this structure currently. In this study, an 18-story new staggered story isolated system model is established using SAP2000. The dynamic nonlinear dynamic alternate method is used to analyze the structure against progressive collapse. Results show that the structure has good resistance to progressive collapse, and there is no progressive collapse under each working condition. The progressive collapse does not occur for the case of removing only one vertical structural member of the new staggered of isolated system. The side column has big influence on this isolated structures’ progressive collapse;the removal of vertical structural member of the isolation layer has less impact on the structure than the removal of the bottom vertical structural member. After the removing of the member, the internal force of the structure will be redistributed, and the axial force of the adjacent columns will change obviously, showing a trend of “near large and far small”.展开更多
Accurate measurement of the average plasma parameters in the edge region,including the temperature and density of electrons and ions,is critical for understanding the characteristics of the scrape-off layer(SOL) and d...Accurate measurement of the average plasma parameters in the edge region,including the temperature and density of electrons and ions,is critical for understanding the characteristics of the scrape-off layer(SOL) and divertor plasma transport in magnetically confined fusion research.On the J-TEXT tokamak,a multi-channel retarding field analyzer(RFA) probe has been developed to study average plasma parameters in the edge region under various poloidal divertor and island divertor configurations.The edge radial profile of the ion-to-electron temperature ratio,τ_(i/e),has been determined,which gradually decreases as the SOL ion self-collisionality,v_(SOL)*,increases.This is broadly consistent with what has been observed previously from various tokamak experiments.However,the comparison of experimental results under different configurations shows that in the poloidal divertor configuration,even under the same v_(SOL)*,τ_(i/e) in the SOL region becomes smaller as the distance from the X-point to the target plate increases.In the island divertor configuration,τ_(i/e) near the O-point is higher than that near the X-point at the same v_(SOL)*,and both are higher than those in the limiter configuration.These results suggest that the magnetic configuration plays a critical role in the energy distributions between electrons and ions at the plasma boundary.展开更多
The thermodynamic properties of boron nitride under extreme pressures and temperatures are of great interest and importance for materials science and inertial confinement fusion physics,but they are poorly understood ...The thermodynamic properties of boron nitride under extreme pressures and temperatures are of great interest and importance for materials science and inertial confinement fusion physics,but they are poorly understood owing to the challenges of performing experiments and realizing ab initio calculations.Here,we report the first shock Hugoniot data on hexagonal boron nitride at pressures of 5–16 Mbar,using hohlraum-driven shock waves at the SGIII-p laser facility in China.Our density functional theory molecular dynamics calculations closely match experimental data,validating the equations of state for modeling the shock response of boron nitride and filling a crucial gap in the knowledge of boron nitride properties in the region of multi-Mbar pressures and eV temperatures.The results presented here provide fundamental insights into boron nitride under the extreme conditions relevant to inertial confinement fusion,hydrogen–boron fusion,and high-energy-density physics.展开更多
Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in ...Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in additional treatment morbidity and even threaten the lives of patients.Thus,designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge.Herein,a series of injectable pH-responsive selfhealing adhesive hydrogels based on acryloyl-6-aminocaproic acid(AA)and AA-g-N-hydroxysuccinimide(AA-NHS)were developed,and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model.The hydrogels showed a suitable gelation time,an autonomous and efficient self-healing capacity,hemostatic properties,and good biocompatibility.With the introduction of AA-NHS as a micro-cross-linker,the hydrogels exhibited enhanced adhesive strength.A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding.A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition,α-SMA expression,and blood vessel formation.These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.展开更多
Microfibrillated cellulose(MFC)is often added to polylactic acid(PLA)matrixes as a reinforcing filler to obtain fully-biodegradable composites with improved mechanical properties.However,the incompatibility between MF...Microfibrillated cellulose(MFC)is often added to polylactic acid(PLA)matrixes as a reinforcing filler to obtain fully-biodegradable composites with improved mechanical properties.However,the incompatibility between MFC and the PLA matrix limits the mechanical performance of MFC-reinforced PLA composites.In this paper,DL-lactic acid-grafted-MFC(MFC-g-DL)was used to improve the compatibility with PLA.Reinforced composites were prepared by melt extrusion and hot-cold pressing.The tensile strength of the PLA/MFC-g-DL composite increased by 22.1%compared with that of PLA after adding 1%MFC-g-DL.Scanning electron microscopy(SEM),differential scanning calorimetry(DSC),and dynamic thermomechanical analysis(DMA)were used to explore the enhancement mechanism.The energy dissipation in the MFC network and the improved compatibility between PLA and MFC-g-DL played important roles in the reinforcement.The SEM results showed that there was a closer combination between PLA and MFC-g-DL.The DSC results showed that the addition of cellulose changed the glass transition temperature,melting temperature,and crystallization temperature of PLA.The TG results showed that the initial and maximum decomposition temperature were lower than those of PLA.The ultraviolet spectra showed that the composite had good transparency at a low concentration of MFC-g-DL.展开更多
Developing advanced magnetic divertor configurations to address the coupling of heat and particle exhaust with impurity control is one of the major challenges currently constraining the further development of fusion r...Developing advanced magnetic divertor configurations to address the coupling of heat and particle exhaust with impurity control is one of the major challenges currently constraining the further development of fusion research.It has therefore become the focus of extensive attention in recent years.In J-TEXT,several new divertor configurations,including the high-field-side single-null poloidal divertor and the island divertor,as well as their associated fundamental edge divertor plasma physics,have recently been investigated.The purpose of this paper is to briefly summarize the latest progress and achievements in this relevant research field on J-TEXT from the past few years.展开更多
Summary What is already known about this topic?The psychological impact of the large-scale infection of the population resulting from the end of lockdown measures in China during the coronavirus disease 2019(COVID-19)...Summary What is already known about this topic?The psychological impact of the large-scale infection of the population resulting from the end of lockdown measures in China during the coronavirus disease 2019(COVID-19)pandemic is unknown.What is added by this report?Among all participants,55.7%had depression symptoms,with a significant difference between the infected and non-infected groups,and 30.1%had anxiety.Those who were young,unvaccinated,had lower incomes,and experienced chronic diseases were more likely to experience negative emotions.What are the implications for public health practice?Government officials should take into account the effect of policies on public sentiment during similar public health events and implement tailored community interventions to address any negative sentiment.展开更多
The increasing interest in exploring the correlation between personal-ity traits and real-life individual characteristics has been driven by the growing popularity of the Myers–Briggs Type Indicator(MBTI)on social me...The increasing interest in exploring the correlation between personal-ity traits and real-life individual characteristics has been driven by the growing popularity of the Myers–Briggs Type Indicator(MBTI)on social media plat-forms.To investigate this correlation,we conduct an analysis on a Myers–Briggs Type Indicator(MBTI)-demographic dataset and present MBTIviz,a visualiza-tion system that enables researchers to conduct a comprehensive and accessible analysis of the correlation between personality and demographic variables such as occupation and nationality.While humanities and computer disciplines provide valuable insights into the behavior of small groups and data analysis,analysing demographic data with personality information poses challenges due to the com-plexity of big data.Additionally,the correlation analysis table commonly used in the humanities does not offer an intuitive representation when examining the relationship between variables.To address these issues,our system provides an integrated view of statistical data that presents all demographic information in a single visual format and a more informative and visually appealing approach to presenting correlation data,facilitating further exploration of the linkages between personality traits and real-life individual characteristics.It also includes machine learning predictive views that help nonexpert users understand their personality traits and provide career predictions based on demographic data.In this paper,we utilize the MBTIviz system to analyse the MBTI-demographic dataset,calcu-lating age,gender,and occupation percentages for each MBTI and studying the correlation between MBTI,occupation,and nationality.展开更多
Three-dimensional(3D) equilibrium calculations, including the plasma rotation shielding effect to resonant magnetic perturbations(RMPs) produced by the island divertor(ID) coils, were carried out using the HINT and MA...Three-dimensional(3D) equilibrium calculations, including the plasma rotation shielding effect to resonant magnetic perturbations(RMPs) produced by the island divertor(ID) coils, were carried out using the HINT and MARS-F codes on J-TEXT. Validation of 3D equilibrium calculations with experimental observations demonstrates that the shielding effect will prevent the penetration of the edge m/n = 3/1 mode component when the ID coil current is 4 k A, while change the size of magnetic islands once the current exceeds the penetration threshold. This indicates that equilibrium calculations including the plasma rotation shielding effect to RMPs can lead to better agreements with experimental observations compared to the vacuum approximation method. Additionally, the magnetic topology at the boundary undergoes changes,impacting the interaction between the plasma and the target plate. These results may be important in understanding RMP effects on edge transport and magnetohydrodynamic(MHD)instability control, as well as divertor heat and particle flux distribution control.展开更多
With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds,the development of new antibacterial and accelerated wound healing dressings has become a serio...With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds,the development of new antibacterial and accelerated wound healing dressings has become a serious challenge.In order to solve this problem,we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan(CSG-PEG),methacrylamide dopamine(DMA)and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing.The mechanical properties,rheological properties and morphology of hydrogels were characterized,and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests.These hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation model.In addition,it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus(MRSA).In the full-thickness skin defect model infected with MRSA,the wound closure ratio,thickness of granulation tissue,number of collagen deposition,regeneration of blood vessels and hair follicles were measured.The inflammation-related cytokines(CD68)and angiogenesis-related cytokines(CD31)expressed during skin regeneration were studied.All results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™Film,revealing that they have become promising alternative in the healing of infected wounds.展开更多
Electrospun nanofibers have been extensively studied in the biomedical field,including the controlled release of drugs,bionics,cell scaffolds,hemostasis,wound healing,and tissue engineering because of their high poros...Electrospun nanofibers have been extensively studied in the biomedical field,including the controlled release of drugs,bionics,cell scaffolds,hemostasis,wound healing,and tissue engineering because of their high porosity,large surface area-to-volume ratio,and programmable features.In recent years researchers have continuously broadened the structural design of electrospun nanofibers,which have evolved from one-dimensional to three-dimensional structures,in order to diversify their function.These properties enable nanofibers to structurally and functionally mimic natural extracellular matrix(ECM),thereby obtaining a favorable physiological microenvironment for both wound healing and hemostasis due to improved blood coagulation and concentration.A comprehensive review summarizing the recent research progress of the structural and functional design of electrospun nanofibers for hemostasis and wound healing,on the other hand,is lacking.This review summarizes electrospun nanofibers used for hemostasis and wound healing,with a focus on structural design and modification strategies.The wide application of electrospun nanofibers in hemostasis and wound healing is clarified using a special structural and innovative design for electrospinning.The advantages and limitations of electrospun nanofibers with various structural forms are also discussed,as are the main challenges and future development directions for the development of structurally specific electrospun nanofibers for hemostasis and wound healing.展开更多
文摘A new staggered isolated system developed from the mid-story isolated system is the new staggered story isolated system. There are not many studies on this structure currently. In this study, an 18-story new staggered story isolated system model is established using SAP2000. The dynamic nonlinear dynamic alternate method is used to analyze the structure against progressive collapse. Results show that the structure has good resistance to progressive collapse, and there is no progressive collapse under each working condition. The progressive collapse does not occur for the case of removing only one vertical structural member of the new staggered of isolated system. The side column has big influence on this isolated structures’ progressive collapse;the removal of vertical structural member of the isolation layer has less impact on the structure than the removal of the bottom vertical structural member. After the removing of the member, the internal force of the structure will be redistributed, and the axial force of the adjacent columns will change obviously, showing a trend of “near large and far small”.
基金supported by the National Magnetic Confinement Fusion Energy R&D Program of China (No.2018YFE0309100)National Natural Science Foundation of China (No.51821005)。
文摘Accurate measurement of the average plasma parameters in the edge region,including the temperature and density of electrons and ions,is critical for understanding the characteristics of the scrape-off layer(SOL) and divertor plasma transport in magnetically confined fusion research.On the J-TEXT tokamak,a multi-channel retarding field analyzer(RFA) probe has been developed to study average plasma parameters in the edge region under various poloidal divertor and island divertor configurations.The edge radial profile of the ion-to-electron temperature ratio,τ_(i/e),has been determined,which gradually decreases as the SOL ion self-collisionality,v_(SOL)*,increases.This is broadly consistent with what has been observed previously from various tokamak experiments.However,the comparison of experimental results under different configurations shows that in the poloidal divertor configuration,even under the same v_(SOL)*,τ_(i/e) in the SOL region becomes smaller as the distance from the X-point to the target plate increases.In the island divertor configuration,τ_(i/e) near the O-point is higher than that near the X-point at the same v_(SOL)*,and both are higher than those in the limiter configuration.These results suggest that the magnetic configuration plays a critical role in the energy distributions between electrons and ions at the plasma boundary.
文摘The thermodynamic properties of boron nitride under extreme pressures and temperatures are of great interest and importance for materials science and inertial confinement fusion physics,but they are poorly understood owing to the challenges of performing experiments and realizing ab initio calculations.Here,we report the first shock Hugoniot data on hexagonal boron nitride at pressures of 5–16 Mbar,using hohlraum-driven shock waves at the SGIII-p laser facility in China.Our density functional theory molecular dynamics calculations closely match experimental data,validating the equations of state for modeling the shock response of boron nitride and filling a crucial gap in the knowledge of boron nitride properties in the region of multi-Mbar pressures and eV temperatures.The results presented here provide fundamental insights into boron nitride under the extreme conditions relevant to inertial confinement fusion,hydrogen–boron fusion,and high-energy-density physics.
基金This work was jointly supported by the National Natural Science Foundation of China(grant Nos.:51973172,51673155,81201927,82002957 and 81672460)the National Key Research and Development Plan of China(No.2018YFC0115300)+5 种基金the State Key Laboratory for Mechanical Behavior of Materials,the World-Class Universities(Disciplines)the Characteristic Development Guidance Funds for the Central Universities,the Natural Science Foundation of Shaanxi Province(No.2020JC-03 and 2019TD-020)the Innovation Talent Promotion Plan of Shaanxi(No.2017KJXX-07)the Key Research and Development Program of Shaanxi Province(No.2019SF-012)the Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University(No.2019LHM-KFKT008)Fundamental Research Funds for the Central Universities of China(No.xjj2018090).
文摘Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in additional treatment morbidity and even threaten the lives of patients.Thus,designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge.Herein,a series of injectable pH-responsive selfhealing adhesive hydrogels based on acryloyl-6-aminocaproic acid(AA)and AA-g-N-hydroxysuccinimide(AA-NHS)were developed,and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model.The hydrogels showed a suitable gelation time,an autonomous and efficient self-healing capacity,hemostatic properties,and good biocompatibility.With the introduction of AA-NHS as a micro-cross-linker,the hydrogels exhibited enhanced adhesive strength.A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding.A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition,α-SMA expression,and blood vessel formation.These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.
基金the Natural Science Foundation of China(No.32071704).
文摘Microfibrillated cellulose(MFC)is often added to polylactic acid(PLA)matrixes as a reinforcing filler to obtain fully-biodegradable composites with improved mechanical properties.However,the incompatibility between MFC and the PLA matrix limits the mechanical performance of MFC-reinforced PLA composites.In this paper,DL-lactic acid-grafted-MFC(MFC-g-DL)was used to improve the compatibility with PLA.Reinforced composites were prepared by melt extrusion and hot-cold pressing.The tensile strength of the PLA/MFC-g-DL composite increased by 22.1%compared with that of PLA after adding 1%MFC-g-DL.Scanning electron microscopy(SEM),differential scanning calorimetry(DSC),and dynamic thermomechanical analysis(DMA)were used to explore the enhancement mechanism.The energy dissipation in the MFC network and the improved compatibility between PLA and MFC-g-DL played important roles in the reinforcement.The SEM results showed that there was a closer combination between PLA and MFC-g-DL.The DSC results showed that the addition of cellulose changed the glass transition temperature,melting temperature,and crystallization temperature of PLA.The TG results showed that the initial and maximum decomposition temperature were lower than those of PLA.The ultraviolet spectra showed that the composite had good transparency at a low concentration of MFC-g-DL.
基金supported by the National MCF Energy R&D Program of China(Nos.2018YFE0309100 and 2018YFE0310300)the National Key R&D Program of China(No.2017YFE0302000)National Natural Science Foundation of China(No.51821005)
文摘Developing advanced magnetic divertor configurations to address the coupling of heat and particle exhaust with impurity control is one of the major challenges currently constraining the further development of fusion research.It has therefore become the focus of extensive attention in recent years.In J-TEXT,several new divertor configurations,including the high-field-side single-null poloidal divertor and the island divertor,as well as their associated fundamental edge divertor plasma physics,have recently been investigated.The purpose of this paper is to briefly summarize the latest progress and achievements in this relevant research field on J-TEXT from the past few years.
文摘Summary What is already known about this topic?The psychological impact of the large-scale infection of the population resulting from the end of lockdown measures in China during the coronavirus disease 2019(COVID-19)pandemic is unknown.What is added by this report?Among all participants,55.7%had depression symptoms,with a significant difference between the infected and non-infected groups,and 30.1%had anxiety.Those who were young,unvaccinated,had lower incomes,and experienced chronic diseases were more likely to experience negative emotions.What are the implications for public health practice?Government officials should take into account the effect of policies on public sentiment during similar public health events and implement tailored community interventions to address any negative sentiment.
基金The paper is supported by the NationalNature Science Foundation of China(Grant No.61100053)a research grant from Intel Asia-PacificResearch and Development Co.,Ltd.
文摘The increasing interest in exploring the correlation between personal-ity traits and real-life individual characteristics has been driven by the growing popularity of the Myers–Briggs Type Indicator(MBTI)on social media plat-forms.To investigate this correlation,we conduct an analysis on a Myers–Briggs Type Indicator(MBTI)-demographic dataset and present MBTIviz,a visualiza-tion system that enables researchers to conduct a comprehensive and accessible analysis of the correlation between personality and demographic variables such as occupation and nationality.While humanities and computer disciplines provide valuable insights into the behavior of small groups and data analysis,analysing demographic data with personality information poses challenges due to the com-plexity of big data.Additionally,the correlation analysis table commonly used in the humanities does not offer an intuitive representation when examining the relationship between variables.To address these issues,our system provides an integrated view of statistical data that presents all demographic information in a single visual format and a more informative and visually appealing approach to presenting correlation data,facilitating further exploration of the linkages between personality traits and real-life individual characteristics.It also includes machine learning predictive views that help nonexpert users understand their personality traits and provide career predictions based on demographic data.In this paper,we utilize the MBTIviz system to analyse the MBTI-demographic dataset,calcu-lating age,gender,and occupation percentages for each MBTI and studying the correlation between MBTI,occupation,and nationality.
基金supported by the National Magnetic Confinement Fusion Energy R & D Program of China (No. 2018 YFE0309101)National Natural Science Foundation of China (Nos. 12305243 and 51821005)。
文摘Three-dimensional(3D) equilibrium calculations, including the plasma rotation shielding effect to resonant magnetic perturbations(RMPs) produced by the island divertor(ID) coils, were carried out using the HINT and MARS-F codes on J-TEXT. Validation of 3D equilibrium calculations with experimental observations demonstrates that the shielding effect will prevent the penetration of the edge m/n = 3/1 mode component when the ID coil current is 4 k A, while change the size of magnetic islands once the current exceeds the penetration threshold. This indicates that equilibrium calculations including the plasma rotation shielding effect to RMPs can lead to better agreements with experimental observations compared to the vacuum approximation method. Additionally, the magnetic topology at the boundary undergoes changes,impacting the interaction between the plasma and the target plate. These results may be important in understanding RMP effects on edge transport and magnetohydrodynamic(MHD)instability control, as well as divertor heat and particle flux distribution control.
基金jointly supported by the National Natural Science Foundation of China(grant numbers:51973172,and 51673155)the Natural Science Foundation of Shaanxi Province(No.2020JC-03 and 2019TD-020)+5 种基金State Key Laboratory for Mechanical Behavior of Materials,and the Fundamental Research Funds for the Central Universitiesthe World-Class Universities(Disciplines)and the Characteristic Development Guidance Funds for the Central UniversitiesOpening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University(No.2019LHM-KFKT008)the Key R&D Program of Shaanxi Province(No.2019ZDLSF02-09-01,2020GXLH-Y-019)Innovation Capability Support Program of Shaanxi Province(Program No.2019GHJD-14,2021TD-40)Scientific Research Program Funded by Shaanxi Provincial Education Department(Program No.18JC027).
文摘With the increasing prevalence of drug-resistant bacterial infections and the slow healing of chronically infected wounds,the development of new antibacterial and accelerated wound healing dressings has become a serious challenge.In order to solve this problem,we developed photo-crosslinked multifunctional antibacterial adhesive anti-oxidant hemostatic hydrogel dressings based on polyethylene glycol monomethyl ether modified glycidyl methacrylate functionalized chitosan(CSG-PEG),methacrylamide dopamine(DMA)and zinc ion for disinfection of drug-resistant bacteria and promoting wound healing.The mechanical properties,rheological properties and morphology of hydrogels were characterized,and the biocompatibility of these hydrogels was studied through cell compatibility and blood compatibility tests.These hydrogels were tested for the in vitro blood-clotting ability of whole blood and showed good hemostatic ability in the mouse liver hemorrhage model and the mouse-tail amputation model.In addition,it has been confirmed that the multifunctional hydrogels have good inherent antibacterial properties against Methicillin-resistant Staphylococcus aureus(MRSA).In the full-thickness skin defect model infected with MRSA,the wound closure ratio,thickness of granulation tissue,number of collagen deposition,regeneration of blood vessels and hair follicles were measured.The inflammation-related cytokines(CD68)and angiogenesis-related cytokines(CD31)expressed during skin regeneration were studied.All results indicate that these multifunctional antibacterial adhesive hemostatic hydrogels have better healing effects than commercially available Tegaderm™Film,revealing that they have become promising alternative in the healing of infected wounds.
基金supported by the National Natural Science Foundation of China(grant number:51973172)Natural Science Foundation of Shaanxi Province(No.2020JC-03 and 2019TD-020)+1 种基金the State Key Laboratory for Mechanical Behavior of Materials,the World-Class Universities(Disciplines)Characteristic Development Guidance Funds for the Central Universities.
文摘Electrospun nanofibers have been extensively studied in the biomedical field,including the controlled release of drugs,bionics,cell scaffolds,hemostasis,wound healing,and tissue engineering because of their high porosity,large surface area-to-volume ratio,and programmable features.In recent years researchers have continuously broadened the structural design of electrospun nanofibers,which have evolved from one-dimensional to three-dimensional structures,in order to diversify their function.These properties enable nanofibers to structurally and functionally mimic natural extracellular matrix(ECM),thereby obtaining a favorable physiological microenvironment for both wound healing and hemostasis due to improved blood coagulation and concentration.A comprehensive review summarizing the recent research progress of the structural and functional design of electrospun nanofibers for hemostasis and wound healing,on the other hand,is lacking.This review summarizes electrospun nanofibers used for hemostasis and wound healing,with a focus on structural design and modification strategies.The wide application of electrospun nanofibers in hemostasis and wound healing is clarified using a special structural and innovative design for electrospinning.The advantages and limitations of electrospun nanofibers with various structural forms are also discussed,as are the main challenges and future development directions for the development of structurally specific electrospun nanofibers for hemostasis and wound healing.