Pancreatic ductal adenocarcinoma（PDAC） is the fourth leading cause of cancer-related death and current therapeutic strategies are often unsatisfactory. Identification and development of more efficacious therapies is...Pancreatic ductal adenocarcinoma（PDAC） is the fourth leading cause of cancer-related death and current therapeutic strategies are often unsatisfactory. Identification and development of more efficacious therapies is urgently needed. Immunotherapy offered encouraging results in preclinical models during the last decades, and several clinical trials have explored its therapeutic application in PDAC. The aim of this review is to summarize the results of clinical trials conducted to evaluate the future perspective of immunotherapy in the treatment of PDAC.展开更多
Dear Editor,Angiogenesis is vital for the development and maintenance of functional organs,and also participates in diverse pathological processes,such as wound healing,oxygen tension,and tumorigenesis(Potente et al.,...Dear Editor,Angiogenesis is vital for the development and maintenance of functional organs,and also participates in diverse pathological processes,such as wound healing,oxygen tension,and tumorigenesis(Potente et al.,2011).Thus,understanding the molecular mechanisms responsible for angiogenesis has important clinical implications and may guide strategies for drug development.展开更多
基金partially supported by American Cancer Society grant IRG 57-001-53
文摘Pancreatic ductal adenocarcinoma（PDAC） is the fourth leading cause of cancer-related death and current therapeutic strategies are often unsatisfactory. Identification and development of more efficacious therapies is urgently needed. Immunotherapy offered encouraging results in preclinical models during the last decades, and several clinical trials have explored its therapeutic application in PDAC. The aim of this review is to summarize the results of clinical trials conducted to evaluate the future perspective of immunotherapy in the treatment of PDAC.
基金supported by grants from the National Key R&D pro-gram of China(2018YFA0800304,2020YFA0803202)the National Natural Science Foundation of China(81772965)Science and Technology Commission o。
文摘Dear Editor,Angiogenesis is vital for the development and maintenance of functional organs,and also participates in diverse pathological processes,such as wound healing,oxygen tension,and tumorigenesis(Potente et al.,2011).Thus,understanding the molecular mechanisms responsible for angiogenesis has important clinical implications and may guide strategies for drug development.
