Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging;they have a great impact on the aging process and are the main risk factors for neurodegeneration.Review...Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging;they have a great impact on the aging process and are the main risk factors for neurodegeneration.Reviewing the microglial response to aging and neuroinflammation in neurodegenerative diseases will help understand the importance of microglia in neurodegenerative diseases.This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases,including Alzheimer's disease,Huntington's chorea,and Parkinson's disease.This review also describes the potential benefits of treating neurodegenerative diseases by modulating changes in microglial states.Therefore,inducing a shift from the neurotoxic to neuroprotective microglial state in neurodegenerative diseases induced by aging and chronic inflammation holds promise for the treatment of neurodegenerative diseases in the future.展开更多
In order to improve the spore yield of compound Bacillus spp. (B. amyloliquefaciens, B. laterosporus and B. megaterium), the effects of nutrient conditions including carbon source, nitrogen source, mineral salt and fe...In order to improve the spore yield of compound Bacillus spp. (B. amyloliquefaciens, B. laterosporus and B. megaterium), the effects of nutrient conditions including carbon source, nitrogen source, mineral salt and fermentation conditions including the inoculum age, inoculation amount, loading volume of liquid and initial pH on the spore yield were studied. The results indicated that the optimized medium was glucoses 20 g/L, soybean meal 30.0 g/L, K2HPO4 1.0 g/L;fermentation temperature is 37℃, the inoculum age 12 h, initial pH 7.0, 2% inoculation amount, loading volume of liquid 20 mL/250 mL. Under the optimized conditions of culture medium and fermentation for compound Bacillus spp., spore yield was 10.24 times more than the initial medium, and the spore formation rate reached more than 90%.展开更多
Aniline blue, one of the triphenylmethane dyes, is the most commonly produced and used of these dyes yet it is also the most dangerous and the most serious cause of pollution amongst them. An exploration of aniline bl...Aniline blue, one of the triphenylmethane dyes, is the most commonly produced and used of these dyes yet it is also the most dangerous and the most serious cause of pollution amongst them. An exploration of aniline blue degradation is likely to facilitate an understanding of the degradation mechanism for a range of related dyes. In this study, we managed to isolate a particular strain of microorganism, identified to be Lysinibacillus fusiformis N019a, which showed a significant capacity for aniline blue degradation in both laboratory tests and natural sewage treatment. In analysis aided by a UV-Visible spectrophotometer, we found that 96.7% of aniline blue had degraded within 24 hours under laboratory conditions. When treating natural sewage, 80.1% of the aniline blue was removed after just 16 hours. Further analysis has shown that Lysinibacillus fusiformis N019a has a strong resistance to Cu2+, Mn2+, Zn2+, and Pb2+. We also found that the degradation product of aniline blue by Lysinibacillus fusiformis N019a was of reduced toxicity to plants and microbes.展开更多
基金supported partly by the National Natural Science Foundation of China,Nos.32161143021 and 81271410the Natural Science Foundation of Henan Province of China,No.182300410313(all to JW)。
文摘Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging;they have a great impact on the aging process and are the main risk factors for neurodegeneration.Reviewing the microglial response to aging and neuroinflammation in neurodegenerative diseases will help understand the importance of microglia in neurodegenerative diseases.This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases,including Alzheimer's disease,Huntington's chorea,and Parkinson's disease.This review also describes the potential benefits of treating neurodegenerative diseases by modulating changes in microglial states.Therefore,inducing a shift from the neurotoxic to neuroprotective microglial state in neurodegenerative diseases induced by aging and chronic inflammation holds promise for the treatment of neurodegenerative diseases in the future.
文摘In order to improve the spore yield of compound Bacillus spp. (B. amyloliquefaciens, B. laterosporus and B. megaterium), the effects of nutrient conditions including carbon source, nitrogen source, mineral salt and fermentation conditions including the inoculum age, inoculation amount, loading volume of liquid and initial pH on the spore yield were studied. The results indicated that the optimized medium was glucoses 20 g/L, soybean meal 30.0 g/L, K2HPO4 1.0 g/L;fermentation temperature is 37℃, the inoculum age 12 h, initial pH 7.0, 2% inoculation amount, loading volume of liquid 20 mL/250 mL. Under the optimized conditions of culture medium and fermentation for compound Bacillus spp., spore yield was 10.24 times more than the initial medium, and the spore formation rate reached more than 90%.
文摘Aniline blue, one of the triphenylmethane dyes, is the most commonly produced and used of these dyes yet it is also the most dangerous and the most serious cause of pollution amongst them. An exploration of aniline blue degradation is likely to facilitate an understanding of the degradation mechanism for a range of related dyes. In this study, we managed to isolate a particular strain of microorganism, identified to be Lysinibacillus fusiformis N019a, which showed a significant capacity for aniline blue degradation in both laboratory tests and natural sewage treatment. In analysis aided by a UV-Visible spectrophotometer, we found that 96.7% of aniline blue had degraded within 24 hours under laboratory conditions. When treating natural sewage, 80.1% of the aniline blue was removed after just 16 hours. Further analysis has shown that Lysinibacillus fusiformis N019a has a strong resistance to Cu2+, Mn2+, Zn2+, and Pb2+. We also found that the degradation product of aniline blue by Lysinibacillus fusiformis N019a was of reduced toxicity to plants and microbes.
