The purpose of this study was to determine perfluoroalkyl substances（PFASs） in human serum, urine, hair and nail from general populations, and to investigate the possibility for human urine, hair and nail used as th...The purpose of this study was to determine perfluoroalkyl substances（PFASs） in human serum, urine, hair and nail from general populations, and to investigate the possibility for human urine, hair and nail used as the biomonitoring sample for PFASs exposure. We detected the concentrations of PFHx A, PFOA, PFNA, PFDA, PFUn DA, PFDo A, PFHx S and PFOS in 39 matched human serum, urine, hair and nail samples from Shenzhen in China. The detection frequency and the median level of PFOS were all higher than that of the other PFASs in four matrices. The median concentration of PFOS in serum, urine, hair, and nail were 9.24 ng/mL, 13.96 ng/L, 0.58 ng/g and 0.63 ng/g, respectively. The results of spearman correlation test indicated that nail was an ideal matrix for biomonitoring PFOS rather than human urine and hair in general populations for the non-invasive sampling.展开更多
Pancreatic cancer(PC)is a highly malignant tumor in the digestive system.The transformation of tissue from normal to pancreatic intraepithelial neoplasm is driven by certain oncogenes,among which the mutation rate of ...Pancreatic cancer(PC)is a highly malignant tumor in the digestive system.The transformation of tissue from normal to pancreatic intraepithelial neoplasm is driven by certain oncogenes,among which the mutation rate of the KRAS gene is as high as 90%.Currently,PC has limited treatment options,low therapeutic effects,and poor prognosis.Thus,more effective methods to combat PC are urgently needed.Some models that can more accurately reflect the biological behaviors and genomic characteristics of PC,such as its morphology,pathology,proliferation,and invasion,are being continuously developed.These include genetic engineering models,orthotopic xenograft models,and heterotopic xenograft models.Using these PC models,scientists have further verified promising drugs and potential therapeutic targets for PC treatment.This is of great significance for limiting the progression of PC with clinical intervention,improving patient outcomes,and improving survival rates.展开更多
基金funded by the National Natural Science of Foundation of China(Nos.21537001 and 21407033)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB14010100)
文摘The purpose of this study was to determine perfluoroalkyl substances（PFASs） in human serum, urine, hair and nail from general populations, and to investigate the possibility for human urine, hair and nail used as the biomonitoring sample for PFASs exposure. We detected the concentrations of PFHx A, PFOA, PFNA, PFDA, PFUn DA, PFDo A, PFHx S and PFOS in 39 matched human serum, urine, hair and nail samples from Shenzhen in China. The detection frequency and the median level of PFOS were all higher than that of the other PFASs in four matrices. The median concentration of PFOS in serum, urine, hair, and nail were 9.24 ng/mL, 13.96 ng/L, 0.58 ng/g and 0.63 ng/g, respectively. The results of spearman correlation test indicated that nail was an ideal matrix for biomonitoring PFOS rather than human urine and hair in general populations for the non-invasive sampling.
基金CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2021-I2M-1-022。
文摘Pancreatic cancer(PC)is a highly malignant tumor in the digestive system.The transformation of tissue from normal to pancreatic intraepithelial neoplasm is driven by certain oncogenes,among which the mutation rate of the KRAS gene is as high as 90%.Currently,PC has limited treatment options,low therapeutic effects,and poor prognosis.Thus,more effective methods to combat PC are urgently needed.Some models that can more accurately reflect the biological behaviors and genomic characteristics of PC,such as its morphology,pathology,proliferation,and invasion,are being continuously developed.These include genetic engineering models,orthotopic xenograft models,and heterotopic xenograft models.Using these PC models,scientists have further verified promising drugs and potential therapeutic targets for PC treatment.This is of great significance for limiting the progression of PC with clinical intervention,improving patient outcomes,and improving survival rates.
