Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective non...Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective nonsurgical treatment and early clinical diagnosis markers,patients have high mortality and low overall survival rates in cholangiocarcinoma(CCA).展开更多
基金This work was supported by the National Natural Science Foundation of China(Nos.62171236 and 61771251)the National Natural Science Foundation of Jiangsu,China(No.BK20171443)+2 种基金sponsored by NUPTSF,China(No.NY220041)the Qinglan Project in Jiangsu Provincethe Priority Academic Program Development of Jiangsu Higher Education Institution(PAPD),China.
文摘Synthetic lethality describes an interaction whereby the co-occurrence of two mutations leads to cell death but one mutation alone does not,which can be exploited for cancer therapeutics.1 Due to lacking effective nonsurgical treatment and early clinical diagnosis markers,patients have high mortality and low overall survival rates in cholangiocarcinoma(CCA).
