Visual Analysis of Epilepsy Diagnosis Based on Brain Functional Connections

Epilepsy is a transient neurological disorder associated with changes in the functional connections of the brain. Abnormal electrical discharges can be observed during an epileptic seizure. However, in the absence of an epileptic seizure, the anatomical structure of the brain and the electrical waves of the brain are not observed, making it difficult to explain the cause. This paper deals with together weighted imaging (DWI) sequence data in functional magnetic resonance imaging (FMRI) of epileptic patients before seizure, using Anatomical Automatic Labeling (AAL) template extracted 116 brain regions and the introduction of time series, a matrix of 116 × 116. Pearson correlation coefficient was calculated to investigate the pathological condition of brain function in epilepsy patients, using of neural network visualization system of innovative visual display and compared with the normal epileptic brain function to connect the image, with 38 cases of epilepsy by 187 cases of normal DWI experiment data, and can confirm the existence of brain function in patients with epilepsy connections. Cerebral neural network visualization system showed partial functional connection loss between frontal lobe and temporal lobe in epileptic group compared with normal control group.

Premature ovarian insufficiency identified as a kidney deficiency and liver constraint pattern treated by Professor Zhiqiang Guo:A retrospective analysis

Objective:To study the efficacy of Professor Zhiqiang Guo's unique sequential herbal therapy in the treatment of premature ovarian insufficiency(POI)of the kidney deficiency and liver constraint pattern.Methods:Ninety patients with POI who consulted with Professor Guo at Dongzimen Hospital,Beijing University of Chinese Medicine from January 2012 to December 2015 were enrolled.Treatment consisted of sequential therapy using traditional Chinese medicine formulae with the actions of nourishing the liver and kidney.Course of treatment was 3 consecutive menstrual cycles for each participant except for those who became pregnant during treatment.Baseline data including age,course of disease,past medical history,lifestyle,pregnancy outcome,menstrual status(cycle length,menstrual flow duration and volume),as well as gonadal hormone levels before and after treatment were recorded and analyzed.Results:During treatment,18(20.0%)participants became pregnant.Symptoms including scanty menstrual flow,irritability,low libido,insomnia and excessive dreaming at night,nightsweats,hot flashes,and depression were markedly alleviated.Changes in follicle-stimulating hormone(FSH)and luteinizing hormone(LH)levels at early follicular stage were observed(P=.009 and P=.002,respectively),and FSH/LH differed significantly pre-and posttreatment(P=.0.44).Conclusion:Professor Guo's sequential Chinese herbal therapy with the actions of nourishing the liver and kidney to treat POI can enhance ovarian function,promote pregnancy,and improve quality of life.

Discovery of the anti-angiogenesis effect of eltrombopag in breast cancer through targeting of HuR protein

HuR(human antigen R), an mRNA-binding protein responsible for poor prognosis in nearly all kinds of malignancies, is a potential anti-tumor target for drug development. While screening HuR inhibitors with a fluorescence polarization(FP) based high-throughput screening(HTS) system, the clinically used drug eltrombopag was identified. Activity of eltrombopag on molecular level was verified with FP, electrophoretic mobility shift assay(EMSA), simulation docking and surface plasmon resonance(SPR). Further, we showed that eltrombopag inhibited in vitro cell proliferation of multiple cancer cell lines and macrophages, and the in vivo anti-tumor activity was also demonstrated in a 4T1 tumor-bearing mouse model. The in vivo data showed that eltrombopag was efficient in reducing microvessels in tumor tissues. We then confirmed the HuR-dependent anti-angiogenesis effect of eltrombopag in 4T1 cells and RAW264.7 macrophages with qRT-PCR, HuR-overexpression and HuR-silencing assays, RNA stability assays, RNA immunoprecipitation and luciferase assays. Finally, we analyzed the in vitro anti-angiogenesis effect of eltrombopag on human umbilical vein endothelial cells(HUVECs) mediated by macrophages with cell scratch assay and in vitro Matrigel angiogenesis assay. With these data, we revealed the HuR-dependent anti-angiogenesis effect of eltrombopag in breast tumor, suggesting that the existing drug eltrombopag may be used as an anti-cancer drug.

Superconductivity above 28K in single unit cell FeSe ?lms interfaced with GaO_(2-δ) layer on NdGaO_3(110)

The discovery of high temperature superconductivity in single unit cell(UC)FeSe on TiO2-δterminated perovskite SrTiO3(001)substrates[1]has attracted intensive attention on searching for new superconducting systems with engineered interfaces as well as understanding the mechanism of interface high temperature superconductivity.