Interfacing DNA and Aptamers with Gold Nanoparticles:From Fundamental Colloid and Interface Sciences to Biosensors

Comprehensive Summary Interfacing DNA oligonucleotides and DNA aptamers with gold nanoparticles has generated numerous functional hybrid materials for sensing,self-assembly and drug delivery applications.Our lab has been working in this area for 15 years.In this article,the current understanding of the adsorption of DNA to gold nanoparticles is summarized,and related applications in bioconjugation of DNA to gold surface is described.In addition,problems of using gold nanoparticles to signaling aptamer binding are discussed.Finally,re-selection of aptamers for previously reported targets using the library-immobilization method is reviewed.

生活质量量表在唇腭裂人群中的研究现状与进展

提高唇腭裂患者生活质量是唇腭裂序列治疗的主要目标,因此,能够准确评估唇腭裂患者的生活质量十分重要。本文介绍了常用的唇腭裂生活质量量表,对不同量表进行了客观比较,讨论了唇腭裂患者生活质量的研究现状与进展,以期为未来的临床工作提供参考。