Summary What is already known about this topic?Identifying the most influential spreaders in human immunodeficiency virus(HIV)transmission networks is crucial for developing effective prevention strategies.What is add...Summary What is already known about this topic?Identifying the most influential spreaders in human immunodeficiency virus(HIV)transmission networks is crucial for developing effective prevention strategies.What is added by this report?This study identified key nodes of the HIV molecular transmission network among men who have sex with men(MSM)by utilizing linkages between sequences to reconstruct the transmission network at the molecular level.展开更多
Background:The harmful effect of aerial fine particulate matter(PM_(2.5))has been a serious public health issue and has attracted worldwide attention,especially in developing countries.Main Text:Numerous previous clin...Background:The harmful effect of aerial fine particulate matter(PM_(2.5))has been a serious public health issue and has attracted worldwide attention,especially in developing countries.Main Text:Numerous previous clinical and experimental studies have demonstrated that PM_(2.5) has a clear pathogenic effect on diseases related to the respiratory and cardiovascular systems.Recent researches have pointed out that PM_(2.5) plays a pivotal role in the occurrence and progression of ocular surface diseases.The current studies have shown that PM_(2.5) may promote the appearance of conjunctivitis,keratitis,blepharitis,dry eye,meibomian gland dysfunction(MGD)and other ocular surface diseases through regulating a series of mechanisms such as inflammation,immune reaction,oxidative stress,autophagy,cell migration,and epigenetics.Conclusions:This review aims to summarize the current research progress on the pathogenic mechanism of PM_(2.5)-related ocular surface diseases.展开更多
基金Supported by the National Natural Science Foundation of China(NSFC)(No.71473234 and 71573239).
文摘Summary What is already known about this topic?Identifying the most influential spreaders in human immunodeficiency virus(HIV)transmission networks is crucial for developing effective prevention strategies.What is added by this report?This study identified key nodes of the HIV molecular transmission network among men who have sex with men(MSM)by utilizing linkages between sequences to reconstruct the transmission network at the molecular level.
基金supported by the National Natural Science Foundation of China(81670833,81870641,and 82070939)Zhejiang Province Key Research and Development Program(2020C03035 and 2019C03091)+1 种基金Fundamental Research Funds for the Central Universities(2019QNA7026)National Natural Science Foundation of Zhejiang Province(LQ14H260003).
文摘Background:The harmful effect of aerial fine particulate matter(PM_(2.5))has been a serious public health issue and has attracted worldwide attention,especially in developing countries.Main Text:Numerous previous clinical and experimental studies have demonstrated that PM_(2.5) has a clear pathogenic effect on diseases related to the respiratory and cardiovascular systems.Recent researches have pointed out that PM_(2.5) plays a pivotal role in the occurrence and progression of ocular surface diseases.The current studies have shown that PM_(2.5) may promote the appearance of conjunctivitis,keratitis,blepharitis,dry eye,meibomian gland dysfunction(MGD)and other ocular surface diseases through regulating a series of mechanisms such as inflammation,immune reaction,oxidative stress,autophagy,cell migration,and epigenetics.Conclusions:This review aims to summarize the current research progress on the pathogenic mechanism of PM_(2.5)-related ocular surface diseases.
