Ex vivo culture-amplified mesenchymal stem cells(MSCs)have been studied because of their capacity for healing tissue injury.MSC transplantation is a valid approach for promoting the repair of damaged tissues and repla...Ex vivo culture-amplified mesenchymal stem cells(MSCs)have been studied because of their capacity for healing tissue injury.MSC transplantation is a valid approach for promoting the repair of damaged tissues and replacement of lost cells or to safeguard surviving cells,but currently the efficiency of MSC transplantation is constrained by the extensive loss of MSCs during the short post-transplantation period.Hence,strategies to increase the efficacy of MSC treatment are urgently needed.Iron overload,reactive oxygen species deposition,and decreased antioxidant capacity suppress the proliferation and regeneration of MSCs,thereby hastening cell death.Notably,oxidative stress(OS)and deficient antioxidant defense induced by iron overload can result in ferroptosis.Ferroptosis may inhibit cell survival after MSC transplantation,thereby reducing clinical efficacy.In this review,we explore the role of ferroptosis in MSC performance.Given that little research has focused on ferroptosis in transplanted MSCs,further study is urgently needed to enhance the in vivo implantation,function,and duration of MSCs.展开更多
Green macroalgae bloom(GMB),with the dominant species of Ulva prolifera,has regularly occurred since 2007 along the China coast.Although disaster prevention and control achieved favorable results in 2020,the satellite...Green macroalgae bloom(GMB),with the dominant species of Ulva prolifera,has regularly occurred since 2007 along the China coast.Although disaster prevention and control achieved favorable results in 2020,the satellite-observed GMB annual maximum coverage(AMC)rebounded sharply in 2021 to an unprecedented level.The reasons for this rebound and the significant interannual variability over past 15 years are still open questions.Here,by using long-term time-series(2007-2022)optical and Synthetic Aperture Radar satellite observations(1000+scenes),meteorological data and water quality statistics,the mechanism analysis was performed by exploring effects from natural factors and human activities.Two key determinants for AMC are successfully identified from numerous potential factors which are the macroalgae distribution in a key area(the Subei Shoal)during a critical period(from April to May 20)and the nutrient availability.Furthermore,by using these two parameters,a novel model for AMC prediction(R^(2)=0.87,p<0.01)is proposed and independently validated,which can reasonably explain the significant interannual variability(2014-2021)and agree well with the latest observation in 2022(percentage difference 12%).Finally,suggestions are proposed for future disaster prevention and alleviation.This work may aid future bloom prediction and management measure optimization.展开更多
基金the Jiangsu Provincial Natural Science Foundation of China(No.BK20220832)。
文摘Ex vivo culture-amplified mesenchymal stem cells(MSCs)have been studied because of their capacity for healing tissue injury.MSC transplantation is a valid approach for promoting the repair of damaged tissues and replacement of lost cells or to safeguard surviving cells,but currently the efficiency of MSC transplantation is constrained by the extensive loss of MSCs during the short post-transplantation period.Hence,strategies to increase the efficacy of MSC treatment are urgently needed.Iron overload,reactive oxygen species deposition,and decreased antioxidant capacity suppress the proliferation and regeneration of MSCs,thereby hastening cell death.Notably,oxidative stress(OS)and deficient antioxidant defense induced by iron overload can result in ferroptosis.Ferroptosis may inhibit cell survival after MSC transplantation,thereby reducing clinical efficacy.In this review,we explore the role of ferroptosis in MSC performance.Given that little research has focused on ferroptosis in transplanted MSCs,further study is urgently needed to enhance the in vivo implantation,function,and duration of MSCs.
基金supported in part by the National Natural Science Foundation of China[grant number 42088101]in part by the Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)[grant number SML2021SP313]+1 种基金in part by the China-Korea Joint Ocean Research Center,China[grant number PI-2022-1]in part by the Fundamental Research Funds for the Central Universities,Sun Yat-sen University[grant number 23xkjc019].
文摘Green macroalgae bloom(GMB),with the dominant species of Ulva prolifera,has regularly occurred since 2007 along the China coast.Although disaster prevention and control achieved favorable results in 2020,the satellite-observed GMB annual maximum coverage(AMC)rebounded sharply in 2021 to an unprecedented level.The reasons for this rebound and the significant interannual variability over past 15 years are still open questions.Here,by using long-term time-series(2007-2022)optical and Synthetic Aperture Radar satellite observations(1000+scenes),meteorological data and water quality statistics,the mechanism analysis was performed by exploring effects from natural factors and human activities.Two key determinants for AMC are successfully identified from numerous potential factors which are the macroalgae distribution in a key area(the Subei Shoal)during a critical period(from April to May 20)and the nutrient availability.Furthermore,by using these two parameters,a novel model for AMC prediction(R^(2)=0.87,p<0.01)is proposed and independently validated,which can reasonably explain the significant interannual variability(2014-2021)and agree well with the latest observation in 2022(percentage difference 12%).Finally,suggestions are proposed for future disaster prevention and alleviation.This work may aid future bloom prediction and management measure optimization.
