The interaction of hemin with chloroquine, quinine and quini-dine wasinvestigated in 50% water-propylene glycol mixture at pH = 9, 8.1, 7.4 and 6.8 using aspectrophotometric method. The data could be well fitted into ...The interaction of hemin with chloroquine, quinine and quini-dine wasinvestigated in 50% water-propylene glycol mixture at pH = 9, 8.1, 7.4 and 6.8 using aspectrophotometric method. The data could be well fitted into a model consistent with the formationof a 1:1 complex between the reacting partners. In addition, the results indicated that hemincomplexed more strongly with quinidine than with chloroquine and quinine, and the binding constantswere pH-dependent. Moreover, it was proved that the water-propylene glycol mixture is well suitableto the study of the systems containing hemin and quinoline-based drugs.展开更多
基金theTropicalDiseaseResearch/WorldHealthOrganization theNationalNaturalScienceFoundationofChina (No .2 0 13 3 0 3 0 )theChinaScholarshipCouncil (No .99180 0 0 3 )
文摘The interaction of hemin with chloroquine, quinine and quini-dine wasinvestigated in 50% water-propylene glycol mixture at pH = 9, 8.1, 7.4 and 6.8 using aspectrophotometric method. The data could be well fitted into a model consistent with the formationof a 1:1 complex between the reacting partners. In addition, the results indicated that hemincomplexed more strongly with quinidine than with chloroquine and quinine, and the binding constantswere pH-dependent. Moreover, it was proved that the water-propylene glycol mixture is well suitableto the study of the systems containing hemin and quinoline-based drugs.
