目的探讨加速康复外科(enhanced recovery after surgery,ERAS)理念应用于腹腔镜辅助远端胃癌D2根治术患者围术期的安全性与有效性。方法回顾性分析2016年5月至2018年12月福建省立医院腹腔镜辅助远端胃癌D2根治术患者369例,其中156例应...目的探讨加速康复外科(enhanced recovery after surgery,ERAS)理念应用于腹腔镜辅助远端胃癌D2根治术患者围术期的安全性与有效性。方法回顾性分析2016年5月至2018年12月福建省立医院腹腔镜辅助远端胃癌D2根治术患者369例,其中156例应用ERAS模式行围术期处理(ERAS组),213例行传统围术期处理(传统组),对两组患者手术情况及术后恢复情况进行对比分析。结果ERAS组手术时间(196.68±48.65)min略短于传统组(204.92±54.00)min,但两组相比无明显统计学差异,而ERAS组首次排气时间45(38)h短于传统组57(11)h(Z=-5.10,P<0.05),腹腔引流管留置时间5(2)d短于传统组7(1)d(Z=-10.54,P<0.05),术后住院天数6(2)d短于传统组8(2)d(Z=-8.78,P<0.05),住院费用(6.32±0.76)万元低于传统组(6.59±1.12)万元(t=-2.58,P=0.01),差异均有统计学意义;ERAS组非计划再入院患者14例,传统组9例,两组相比差异无统计学意义;ERAS组肺部感染7例少于传统组23例(χ^2=4.80,P=0.03),差异有统计学意义,腹腔积液、腹泻、吻合口瘘、吻合口出血、十二指肠残端瘘、急性尿潴留、切口感染、胃瘫、肠梗阻、泌尿系感染方面,两组相比差异无统计学意义。结论ERAS应用于腹腔镜辅助远端胃癌D2根治术患者围术期是安全有效的。展开更多
Base substitution is one of the raw fuels that produce genetic variation; drive evolution. Recent studies have shown that the genome components affect mutation patterns to some extent. In order to infer the correlatio...Base substitution is one of the raw fuels that produce genetic variation; drive evolution. Recent studies have shown that the genome components affect mutation patterns to some extent. In order to infer the correlation between the Transition/Transversion ratio (Ts/Tv); the number of immediately adjacent A&T nucleotides, we investigated 3611007 Oryza sativa SNPs (including 45462 coding SNPs,; 242811 intronic SNPs); 32019 Arabidopsis SNPs. The results show that Ts/Tv is negatively correlated with the number of immediately adjacent A&T in O. Sativa; Arabidopsis. We further calculated AT2 (the number of SNPs whose immediately adjacent nucleotides are either A or T); AT0 (the number of SNPs whose immediately adjacent nucleotides are either C or G) for all 6 types of SNPs. C/G SNP of O. sativa; Arabidopsis has the highest AT2/AT0, which denotes C/G SNP may be influenced by the adjacent A&T nucleotides mostly. For SNPs in O. sativa, the neighboring effect of A&T nucleotides is limited to 2 nucleotides on both sides; for SNPs in Arabidopsis, the effect extends no more than 4 nucleotides on both sides.展开更多
Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection...Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism (SNP) data from the International HapMap Project. Single locus FST analysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of FST, we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection.展开更多
文摘目的探讨加速康复外科(enhanced recovery after surgery,ERAS)理念应用于腹腔镜辅助远端胃癌D2根治术患者围术期的安全性与有效性。方法回顾性分析2016年5月至2018年12月福建省立医院腹腔镜辅助远端胃癌D2根治术患者369例,其中156例应用ERAS模式行围术期处理(ERAS组),213例行传统围术期处理(传统组),对两组患者手术情况及术后恢复情况进行对比分析。结果ERAS组手术时间(196.68±48.65)min略短于传统组(204.92±54.00)min,但两组相比无明显统计学差异,而ERAS组首次排气时间45(38)h短于传统组57(11)h(Z=-5.10,P<0.05),腹腔引流管留置时间5(2)d短于传统组7(1)d(Z=-10.54,P<0.05),术后住院天数6(2)d短于传统组8(2)d(Z=-8.78,P<0.05),住院费用(6.32±0.76)万元低于传统组(6.59±1.12)万元(t=-2.58,P=0.01),差异均有统计学意义;ERAS组非计划再入院患者14例,传统组9例,两组相比差异无统计学意义;ERAS组肺部感染7例少于传统组23例(χ^2=4.80,P=0.03),差异有统计学意义,腹腔积液、腹泻、吻合口瘘、吻合口出血、十二指肠残端瘘、急性尿潴留、切口感染、胃瘫、肠梗阻、泌尿系感染方面,两组相比差异无统计学意义。结论ERAS应用于腹腔镜辅助远端胃癌D2根治术患者围术期是安全有效的。
基金supported partly by the National 863 Project(Grant No.2003AA231050)National Natural Science Foundation of China(Grant No.10371126)Mega-projects of Science Research for the 10th Five-year Plan(Grant No.2002BA711A09).
文摘Base substitution is one of the raw fuels that produce genetic variation; drive evolution. Recent studies have shown that the genome components affect mutation patterns to some extent. In order to infer the correlation between the Transition/Transversion ratio (Ts/Tv); the number of immediately adjacent A&T nucleotides, we investigated 3611007 Oryza sativa SNPs (including 45462 coding SNPs,; 242811 intronic SNPs); 32019 Arabidopsis SNPs. The results show that Ts/Tv is negatively correlated with the number of immediately adjacent A&T in O. Sativa; Arabidopsis. We further calculated AT2 (the number of SNPs whose immediately adjacent nucleotides are either A or T); AT0 (the number of SNPs whose immediately adjacent nucleotides are either C or G) for all 6 types of SNPs. C/G SNP of O. sativa; Arabidopsis has the highest AT2/AT0, which denotes C/G SNP may be influenced by the adjacent A&T nucleotides mostly. For SNPs in O. sativa, the neighboring effect of A&T nucleotides is limited to 2 nucleotides on both sides; for SNPs in Arabidopsis, the effect extends no more than 4 nucleotides on both sides.
文摘Natural selection, as the driving force of human evolution, has direct impact on population differentiation. However, it is still unclear to what extent the genetic differentiation has been caused by natural selection. To explore this question, we performed a genome-wide scan with single nucleotide polymorphism (SNP) data from the International HapMap Project. Single locus FST analysis was applied to assess the frequency difference among populations in autosomes. Based on the empirical distribution of FST, we identified 12669 SNPs correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. Further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. Our results suggest that natural selection may play an important role in human population differentiation. In addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection.
