Alzheimer’s disease(AD)is the most common neurodegenerative disease characterized by progressive cognitive impairment.The pathogenesis of AD is complex,and its susceptibility and development process are affected by a...Alzheimer’s disease(AD)is the most common neurodegenerative disease characterized by progressive cognitive impairment.The pathogenesis of AD is complex,and its susceptibility and development process are affected by age,genetic and epigenetic factors.Recent studies confirmed that gut microbiota(GM)might contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflammatory and immune processes.CM formula,herbs,and monomer enjoy unique advantages to treat and prevent AD.Hence,the purpose of this review is to outline the roles of GM and its core metabolites in the pathogenesis of AD.Research progress of CMs regarding the mechanisms of how they regulate GM to improve cognitive impairment of AD is also reviewed.The authors tried to explore new therapeutic strategies to AD based on the regulation of GM using CM.展开更多
基金Supported by National Natural Science Foundation of China(No.81704004)Scientific and Technological Research Program of Tianjin Municipal Education Commission(No.2018KJ031)Research and Innovation Project of Graduate(No.YJSKC-20191003,No.ZXYCXLX201804)。
文摘Alzheimer’s disease(AD)is the most common neurodegenerative disease characterized by progressive cognitive impairment.The pathogenesis of AD is complex,and its susceptibility and development process are affected by age,genetic and epigenetic factors.Recent studies confirmed that gut microbiota(GM)might contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflammatory and immune processes.CM formula,herbs,and monomer enjoy unique advantages to treat and prevent AD.Hence,the purpose of this review is to outline the roles of GM and its core metabolites in the pathogenesis of AD.Research progress of CMs regarding the mechanisms of how they regulate GM to improve cognitive impairment of AD is also reviewed.The authors tried to explore new therapeutic strategies to AD based on the regulation of GM using CM.
