期刊文献+
共找到11篇文章
< 1 >
每页显示 20 50 100
科研机构分类模型构建:基于巴斯德象限模型的视角 被引量:1
1
作者 曾志敏 朱冰妍 柴茂昌 《科学管理研究》 北大核心 2023年第4期48-55,共8页
科研机构分类改革是我国科技体制改革的重要组成部分,对科研机构实施分类管理,有助于提升科研机构的管理效率和创新体系的整体效能。建立科学、合理的科研机构分类模型,是科研机构分类管理的首要前提和基础。基于科研活动的性质划分,对... 科研机构分类改革是我国科技体制改革的重要组成部分,对科研机构实施分类管理,有助于提升科研机构的管理效率和创新体系的整体效能。建立科学、合理的科研机构分类模型,是科研机构分类管理的首要前提和基础。基于科研活动的性质划分,对司托克斯的巴斯德象限模型进行拓展与改造,根据科研机构承担的科研活动性质及其核心使命构建科研机构分类模型,将科研机构划分为知识创造型、产业转化型和战略前沿型三种类型,分别介绍了这三种类型科研机构在国家战略科技力量和国际科研机构中的典型代表。从理论和战略层面提出了一种科研机构分类构想,为进一步深化科研机构分类管理、强化国家战略科技力量提供决策参考。 展开更多
关键词 科研机构 分类管理 巴斯德象限模型 国家战略科技力量 科技体制改革
下载PDF
半髋置换治疗高龄股骨颈骨折的快速康复疗效 被引量:17
2
作者 曾智敏 黄哲宇 +2 位作者 陶崑 凌晶 狄正林 《中国骨伤》 CAS 2018年第12期1100-1103,共4页
目的:高龄股骨颈骨折患者应用快速康复理念进行半髋关节置换手术治疗,分析并评价其早期临床疗效。方法:2015年1月至2016年12月收治股骨颈骨折患者466例,进行回顾性分析,其中高龄患者154例,年龄80~96(83.9±3.2)岁,女127例,男27例,G... 目的:高龄股骨颈骨折患者应用快速康复理念进行半髋关节置换手术治疗,分析并评价其早期临床疗效。方法:2015年1月至2016年12月收治股骨颈骨折患者466例,进行回顾性分析,其中高龄患者154例,年龄80~96(83.9±3.2)岁,女127例,男27例,GardenⅢ型68例,GardenⅣ型86例,应用快速康复理念优化围手术治疗策略,进行半髋关节置换手术治疗。记录手术等待时间、手术时间、术后输血率、住院时间、并发症及术后髋关节功能等,统计并分析评价其临床疗效。结果:154例患者中,12例失访,随访率为92.2%,平均随访时间24.6个月(14~38个月),32例(20.8%)在入院48 h内完成手术,67例(43.5%)在入院72 h内完成手术,76例(49.4%)术后48 h内出院,术后输血率15.9%。1例因假体脱位再次入院,再入院率为0.6%,其余患者无因浅表或深部感染、假体周围骨折再次入院。末次随访患者Harris髋关节评分90.2±7.1,优106例,良23例,可9例。结论:应用快速康复理念半髋关节置换治疗高龄股骨颈骨折患者,可有效缩短住院时间,减轻患者痛苦,降低输血率,降低术后并发症率,同时不增加患者的再入院率,能取得良好的临床疗效。 展开更多
关键词 股骨颈骨折 康复 关节成形术 置换
下载PDF
固定平台单髁置换术治疗膝关节内侧骨性关节炎 被引量:10
3
作者 曾智敏 陶崑 +2 位作者 凌晶 黄哲宇 狄正林 《中国骨伤》 CAS CSCD 2019年第8期755-758,共4页
目的:探讨采用固定平台假体膝关节单髁置换术治疗膝关节内侧单间室骨性关节炎的早期临床疗效。方法:自2015年1月至2017年12月,采用固定平台单髁置换术治疗62例膝关节内侧间室骨性关节炎患者,其中男19例,女43例;年龄47~83(65.3±8.2)... 目的:探讨采用固定平台假体膝关节单髁置换术治疗膝关节内侧单间室骨性关节炎的早期临床疗效。方法:自2015年1月至2017年12月,采用固定平台单髁置换术治疗62例膝关节内侧间室骨性关节炎患者,其中男19例,女43例;年龄47~83(65.3±8.2)岁;病程5~72(19.4±14.3)个月。观察术后并发症情况,并采用VAS评分评价疼痛缓解程度,HSS膝关节评分评价临床疗效。结果:62例患者均获得随访,时间4~40(19.9±10.2)个月。所有患者切口愈合良好,无须术后输血,住院时间2~10(3.5±1.6)d。术后未发生脱位、感染、松动或假体周围骨折等并发症,1例患者术后1个月并发胫后静脉血栓。HSS评分由术前的69.9±7.2提高至末次随访时的90.1±7.4;其中优51例,良9例,可2例;VAS评分由术前的3.8±0.9降至末次随访时的1.1±0.9。结论:固定平台单髁关节置换术治疗膝关节内侧单间室骨性关节炎术后住院时间短,并发症低,可以获得较好的早期临床疗效。 展开更多
关键词 关节成形术 置换 骨关节炎 骨折固定术
下载PDF
2型固有免疫细胞在过敏性及非过敏性哮喘中的临床意义 被引量:3
4
作者 曾智敏 谭卫平 +4 位作者 黄鑫炎 刘杨丽 李佩文 付清玲 郭禹标 《中山大学学报(医学版)》 CAS CSCD 北大核心 2018年第4期532-539,共8页
【目的】观察过敏性及非过敏性哮喘发病过程中2型固有免疫细胞(ILC2)的差异,探讨ILC2与哮喘临床评价指标的相关性。【方法】研究对象来自我院2017年6月至2018年1月的过敏性和非过敏性哮喘患者,收集相应临床基线资料并评估病情、进行血... 【目的】观察过敏性及非过敏性哮喘发病过程中2型固有免疫细胞(ILC2)的差异,探讨ILC2与哮喘临床评价指标的相关性。【方法】研究对象来自我院2017年6月至2018年1月的过敏性和非过敏性哮喘患者,收集相应临床基线资料并评估病情、进行血常规、肺功能等检查;应用流式细胞术检测外周血ILC2;通过ELISA和多因子检测分别测定总Ig E及s Ig E和Th2型细胞因子。【结果】哮喘(Asthma)组的ILC2比例和计数与嗜酸性粒细胞(EOS)计数及s Ig E正相关(r=0.37,0.32,0.56,0.57;P<0.01~=0.04);过敏性哮喘(AA)组的ILC2比例和计数为0.04(0.03~0.11)%和338(255~778)cells/m L,均高于非过敏性哮喘(NAA)组的0.01(0.01~0.02)%及89(0~169)cells/m L(P<0.01);中/重度患者ILC2比例为(0.10±0.08)%,高于间歇/轻度患者的(0.04±0.01)%(P=0.04);AA组中ILC2比例和计数与FEV1/FVC呈负相关(r=-0.61,-0.56;P<或=0.01)。【结论】ILC2参与过敏性哮喘的发病机制,与EOS表型、过敏炎症反应和病情严重程度相关,可作为过敏性哮喘的有效评价指标之一,为过敏性哮喘的治疗提供新方向。 展开更多
关键词 过敏性哮喘 非过敏性哮喘 2型固有免疫细胞
下载PDF
M3R激动剂通过激活PI3K/AKT信号途径促进肺癌细胞A549的上皮间质转化 被引量:7
5
作者 邢静 林耿鹏 +3 位作者 罗海丹 曾智敏 杨惠玲 郭禹标 《中国病理生理杂志》 CAS CSCD 北大核心 2018年第3期423-427,共5页
目的:探讨毒蕈碱胆碱受体3(muscarinic receptor 3,M3R)激动剂卡巴胆碱促进人肺癌A549细胞上皮间质转化的可能信号通路。方法:用400μmol/L卡巴胆碱刺激人肺癌A549细胞,在倒置相差显微镜下观察细胞形态的变化,应用划痕愈合实验和Transw... 目的:探讨毒蕈碱胆碱受体3(muscarinic receptor 3,M3R)激动剂卡巴胆碱促进人肺癌A549细胞上皮间质转化的可能信号通路。方法:用400μmol/L卡巴胆碱刺激人肺癌A549细胞,在倒置相差显微镜下观察细胞形态的变化,应用划痕愈合实验和Transwell实验观察细胞迁移和侵袭能力;应用q PCR技术检测上皮间质转化相关蛋白波形蛋白(vimentin)和E钙黏蛋白(E-cadherin)m RNA水平的变化;应用Western blot技术检测p-AKT、vimentin和E-cadherin蛋白水平的变化。结果:卡巴胆碱刺激人肺癌A549细胞后,细胞形态发生明显改变,由不规则多边形逐渐向梭形转化、细胞间紧密结合逐渐变得松散,细胞迁移和侵袭能力增强;vimentin的m RNA和蛋白表达量明显增加,E-cadherin的m RNA和蛋白水平降低,磷酸化的AKT蛋白水平增加,且这些变化均可被M3R特异性抑制剂4-DAMP所抑制(P<0.05)。结论:卡巴胆碱可通过激活PI3K/AKT信号途径促进人肺癌A549细胞发生上皮间质转化。 展开更多
关键词 毒蕈碱胆碱受体3 肺癌 上皮间质转化 PI3K/AKT信号通路
下载PDF
不同人格特质对成人隐形矫治患者口腔健康相关生活质量的影响 被引量:1
6
作者 曾志敏 彭松娟 +2 位作者 陈雅莉 杨琪琦 胡江天 《昆明医科大学学报》 CAS 2019年第3期39-44,共6页
目的研究隐形矫治治疗初期不同人格特质对患者口腔健康相关生活质量(OHRQOL)的影响。方法随机抽取成人隐形矫治患者82例。运用艾森克人格问卷中国简式量表问卷(EPQ-RSC)将患者分为内向型、中间型及外向型3组。收集患者矫治前(T0)、矫治1... 目的研究隐形矫治治疗初期不同人格特质对患者口腔健康相关生活质量(OHRQOL)的影响。方法随机抽取成人隐形矫治患者82例。运用艾森克人格问卷中国简式量表问卷(EPQ-RSC)将患者分为内向型、中间型及外向型3组。收集患者矫治前(T0)、矫治1周(T1)、矫治1个月(T2) 3个时期的口腔健康影响程度量表(OHIP-14)问卷,比较不同人格特质患者隐形矫治治疗初期口腔健康相关生活质量的差异。结果隐形矫治治疗后,患者的生活质量受到一定的影响,OHRQOL评分升高,在T1期达到峰值,T2期分值均有下降,内向组T2期与T0期比较在心理不适、心理障碍方面差异有统计学意义(P<0.01);T2期与T1期比较在心理不适方面差异有统计学意义(P<0.01);外向组T2期与T0期比较仅在心理不适方面有差异(P<0.05)。不同人格特质患者,在T0期外向组与内向组比较,在社交障碍、残障差异有统计学意义(P<0.01);心里不适、生理疼痛、功能障碍方面差异有统计学意义(P<0.05);与中间组比较,外向组在生理疼痛、生理障碍、残障等方面有统计学意义(P<0.01)。在T1期内向组得分明显高于外向组,与内向组比较,中间组仅心理不适方面差异有统计学意义(P<0.01);外向组在生理疼痛,残障方面差异有统计学意义(P<0.05)。在T2期外向组和中间组在生理疼痛、生理障碍方面差异有统计学意义(P<0.01)。结论隐形矫治治疗对患者口腔健康相关生活质量有影响,内向型患者较外向型受影响程度更重,主要表现在疼痛及心理不适。 展开更多
关键词 成人 隐形矫治 人格特质 口腔健康相关生活质量
下载PDF
Asynchronous diversity receiving scheme and analysis on cooperative relay networks 被引量:1
7
作者 ZHANG Ying-hui ZHANG Tian-kui +1 位作者 SAEED-Muhammad zeng zhi-min 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2014年第1期10-15,35,共7页
The transmission antennas of cooperative systems are spatially distributed on multiple nodes, so the received signal can be asynchronous due to propagation delays. A receiving scheme for cooperative relay networks is ... The transmission antennas of cooperative systems are spatially distributed on multiple nodes, so the received signal can be asynchronous due to propagation delays. A receiving scheme for cooperative relay networks is proposed, multiple asynchronous signals are reconstructed at the receiver by forward and backward interference cancellation, which can obtain gains of cooperative transmission diversity with obvious delay and with no requiring timing synchronization or orthogonal channelization between relays. Analysis and simulation show that the bit error rate(BER) of the proposed scheme is similar to Alamouti code, and the scheme has the diversity order of orthogonal transmission scheme accompanied by minimal BER losses. It is demonstrated that the performance can be further improved by adding an error correcting code(ECC). 展开更多
关键词 relay networks asynchronous communications cooperative diversity interference cancellation
原文传递
Multi-cell uplink power allocation game for user minimum performance guarantee in OFDMA systems 被引量:1
8
作者 ZHANG Tian-kui XIAO Lin +1 位作者 zeng zhi-min Laurie Cuthbert 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2010年第5期6-11,49,共7页
The multi-cell uplink power allocation problem for orthogonal frequency division multiplexing access (OFDMA) cellular networks is investigated with the uplink transmission power allocation on each co-frequency subch... The multi-cell uplink power allocation problem for orthogonal frequency division multiplexing access (OFDMA) cellular networks is investigated with the uplink transmission power allocation on each co-frequency subchannel being defined as a multi-cell non-cooperative power allocation game (MNPG).The principle of the design of the utility function is given and a novel utility function is proposed for MNPG.By using this utility function,the minimum signal to interference plus noise ratio (SINR) requirement of a user can be guaranteed.It can be shown that MNPG will converge to the Nash equilibrium and that this Nash equilibrium is unique.In considering the simulation results,the effect of the algorithm parameters on the system performance is discussed,and the convergence of the MNPG is verified.The performance of MNPG is compared with that of traditional power allocation schemes,the simulation results showing that the proposed algorithm increases the cell-edge user throughput greatly with only a small decrease in cell total throughput; this gives a good tradeoff between the throughput of cell-edge users and the system spectrum efficiency. 展开更多
关键词 OFDMA power allocation non-cooperative game Nash equilibrium
原文传递
Nash bargaining solution based multi-cell and multi-user interference alignment scheme for cellular networks
9
作者 NIU Qin zeng zhi-min +2 位作者 ZHANG Tian-kui GAO Qiu-bin SUN Shao-hui 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2014年第4期1-7,14,共8页
In wireless cellular networks, the interference alignment (IA) is a promising technique for interference management. A new IA scheme for downlink cellular network with multi-cell and multi-user was proposed, in the ... In wireless cellular networks, the interference alignment (IA) is a promising technique for interference management. A new IA scheme for downlink cellular network with multi-cell and multi-user was proposed, in the proposed scheme, the interference in the networks is divided into inter-cell interference (ICI) among cells and inter-user interference (IUI) in each cell. The ICI is aligned onto a multi-dimensional subspace by multiplying the ICI alignment precoding matrix which is designed by the singular value decomposition (SVD) scheme at the base station (BS) side. The aligned ICI is eliminated by timing the interference suppression matrix which is designed by zero-forcing (ZF) scheme at the user equipment (UE) side. Meanwhile, the IUI is aligned by multiplying the IUI alignment precoding matrix which is designed based on Nash bargaining solution (NBS) in game theory. The NBS is solved by the particle swarm optimization (PSO) method. Simulations show that, compared with the traditional ZF IA scheme, the proposed scheme can obtain higher data rate and guarantee the data rate fairness of UEs with little additional complexity. 展开更多
关键词 cellular network interference alignment Nash bargaining solution data rate fairness particle swarm optimization
原文传递
Low-cost binding update scheme based on pointer forwarding in HMIPv6 network
10
作者 LIU Yin-long zeng zhi-min +2 位作者 XIA Hai-lun ZHANG Tian-kui HAO Xiao-yan 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2010年第3期73-77,共5页
By introducing a mobility anchor point (MAP), hierarchical mobile IPv6 (HMIPv6) reduces the binding update signaling cost associated with mobile IPv6, but there still exist deficiencies. For instance, a mobile no... By introducing a mobility anchor point (MAP), hierarchical mobile IPv6 (HMIPv6) reduces the binding update signaling cost associated with mobile IPv6, but there still exist deficiencies. For instance, a mobile node (MN) needs to orderly accomplish two binding updates with the MAP and home agent (HA) when the MN performs inter-MAP mobility. This results in a high signaling cost, thus affecting network performance. To reduce the inter-MAP binding update cost of idle MN in HMIPv6, an optimization scheme based on pointer forwarding with a threshold is proposed. The scheme can reduces the binding update cost of idle MN by using the binding update between MAP to replace several home binding updates. The signaling cost difference is derived by analyzing the cost of the basic scheme and the optimization scheme between two successive sessions. Simulation results show that, the optimization scheme can reduce the binding update signaling cost and improve the network performance as long as a suitable threshold is chosen. The discussions on the sensitivity of tele-parameters are also given. 展开更多
关键词 hierarchical MIPv6 binding update pointer forwarding signaling cost
原文传递
Evolved data scheduling scheme based on layered P2P streaming in mobile network
11
作者 XIA Hai-lun WANG Ning zeng zhi-min 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2012年第3期60-67,共8页
To relieve the negative effect brought by the intricate wireless network environment and unstable user behavior in layered mobile peer-to peer(P2P) streaming service, an evolved layered P2P (E-LP2P) data schedulin... To relieve the negative effect brought by the intricate wireless network environment and unstable user behavior in layered mobile peer-to peer(P2P) streaming service, an evolved layered P2P (E-LP2P) data scheduling scheme in the process of service delivery is introduced in this paper. The data in base layer is scheduled according to its importance in streaming play to guarantee the basic play of streaming. The data in enhancement layer is scheduled according to the characters of streaming data, including its position and amount in server peer set in a multiple tied way towards the data in enhancement layer. To cope with the layer jitter caused by the fluctuation of bandwidth, jitter prevent mechanism is used to adjust the highest layer dynamically during the process of data scheduling. Simulation results show that the E-LP2P can provide good quality of service(QoS) performance in terms of throughput, layer delivery ratio, server load and useless packet ratio. 展开更多
关键词 layered streaming P2P mobile network data scheduling
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部