朱权《活人心法》养生之道探赜

《活人心法》为宁献王朱权所著,全书分为上下两卷。其中上卷蕴含了丰富的养生思想和方法,从心、神、气的内调与起居、饮食、形体官窍、脏腑的外养两方面论述了养生延年之理。从治心之则与修养之法两方面对《活人心法》中的养生之道进行阐述,展现朱权对于保养生命的独特见解。

葛根质量标志物(Q-marker)探讨分析

以葛根为主药的中药制剂临床疗效显著,但是葛根素口服吸收差,消除快,生物利用度低,若以葛根素为质量控制指标,无法完全反映葛根为主药的中药制剂疗效。基于刘昌孝院士提出的中药质量标志物(Q-marker)新概念,从成分特有性、传统功效、传统药性、成分可测性、中药配伍环境(药对配伍、复方配伍、经典方配伍)、成分有效性等几个方面对葛根质量标志物(Q-marker)进行探讨分析,为葛根及其制剂质量评价研究提供思路。

95例新型冠状病毒肺炎患者中医体质类型分布研究

目的:探讨新型冠状病毒肺炎患者中医体质类型分布,为中医药早期干预与预防提供依据。方法:应用横断面研究方法,通过问卷星形式完成95例新型冠状病毒肺炎患者中医体质量表与相关因素调查,通过数据统计分析,探索新型冠状病毒肺炎患者体质类型分布规律及相关因素(症状、个人生活嗜好、核酸转阴时间等)的关联。结果:(1)患者体质发生频率前5位是平和质、痰湿质、阳虚质、湿热质、阴虚质;兼夹体质前三位的是阴虚兼湿热、痰湿兼湿热、阳虚兼痰湿;(2)患者症状发生频率前5位是发热、咳嗽、乏力、恶寒、出汗;(3)转阴天数1~7d以气郁质、痰湿质、阴虚质、阳虚质、平和质为主;转阴天数7~14d以平和质、阴虚质、阳虚质为主;转阴天数14~21d以湿热质、阴虚质、痰湿质为主;转阴天数21~30d以痰湿质、湿热质、阳虚质为主;截至该研究完成时未转阴以阴虚质、痰湿质、湿热质为主;(4)既往病史及个人生活嗜好以高血压、心脏病/冠心病、肥胖及辛辣食物、甜品、海鲜、饮酒、煎炸食物为主;(5)病情轻重与体质关系:普通型以阴虚质、平和质为主;轻型以平和质、阴虚质为主;重型以痰湿质、阳虚质为主。结论:(1)新型冠状病毒肺炎患者主要中医体质类型为痰湿质、气虚质、血瘀质、湿热质;(2)患者的初始症状主要有发热、咳嗽、乏力、恶寒、出汗;(3)湿热、痰湿体质患者新冠病毒核酸转阴时间明显延长;(4)平素嗜好辛辣刺激及甜品患者易感湿热及痰湿体质;(5)痰湿质是加重病情的主要危险因素。

女性中医健康管理效果评估研究

目的:构建女性中医健康管理效果评估指标体系。方法:提取《中医病证诊断疗效标准》和《中药新药临床研究指导原则》中关于月经不调疾病的疾病和证候疗效评价指标及分值标准;搜集与月经不调疾病发病相关的饮食、情志、运动等方面的健康行为,构建月经不调健康行为评分指标。结果:构建了疾病疗效、证候疗效以及健康行为分数组成的女性中医健康管理综合评估指标体系。结论:评估指标体系有助于动态跟踪干预和管理效果,有助于用户及时调整干预方案和改善不良健康行为。

基于脉诊手环的女大学生脉象相关性连续观测分析

目的:探索健康女大学生连续检测的脉象特征及其与月经周期的关系。方法:受试者为17名江西中医药大学女大学生,采用脉诊手环进行脉象测试,测试时间为平旦醒后尚未起床和起床后至睡前的任意一时刻,每日检测,并记录当前月经周期信息;平旦和非平旦脉一致性分析采用Kappa检验,月经分期分析的脉象比较采用卡方检验。结果:平旦脉与非平旦脉一致性较差,除数脉外,Kappa检验P均> 0.05;平旦脉分解脉中滑脉、弦脉占比分别为55.21%、26.03%;经前期、行经期、经后期各脉象比例差别不大,排卵期缓脉、弦脉、涩脉、滑脉占比分别为40.68%、44.07%、30.51%、40.68%,非排卵期分别为17.38%、24.69%、10.45%、56.30%,差异均有显著性,P <0.05。结论:研究表明健康女大学生脉象特征与月经周期有一定相关性,脉象总体以滑脉为主,排卵期较非排卵期滑脉少见,排卵期弦、缓、涩脉较非排卵期多见。

崩漏证型自我辨识模型构建研究

目的:构建适用于崩漏或有崩漏倾向者的证型自我辨识模型。方法:将《中医常见病妇科诊疗指南》中崩漏的证候相关文本进行分词,采用关联规则分析计算证型与症状的置信度,选择置信度>30%的症状作为问卷条目;以每个证型对应的症状置信度总和为100%,然后采用归一法计算证型对应症状的权重值;通过计算选中的症状对应证型权重值总和(即证型相似度)来辅助证型自诊;采用"全或无"验证方法对证型相似度进行比较验证。结果:构建了崩漏中医证型的自诊问卷,问卷条目数共为43条,"全或无"验证结果显示任意两个证型之间相似度最小0,最大为43.8%。结论:研究构建的证型自诊问卷条目数量较少,自诊模型能较好的区分不同证型,对崩漏证型的自我辨识具有较好的应用价值。

应用中药治疗股骨粗隆间骨折PFNA术后对髋关节功能的影响分析

目的探究股骨粗隆间骨折股骨近端防髓内钉(PFNA)术后患者应用中药治疗对髋关节功能的影响分析。方法选取2020年8月—2021年8月收治的76例股骨粗隆间骨折PFNA术后患者,按随机数表法分为试验组和对照组各38例。试验组应用中药治疗,对照组采用常规药物,对比两组手术相关指标、视觉模拟疼痛评分(VAS评分)、患者髋关节功能评分(Harris评分)、术后并发症及术后骨折不愈合率。结果试验组术后住院时间、骨折愈合时间均短于对照组(P<0.05)。术后1个月试验组低于对照组(P<0.05),Harris评分高于对照组(P<0.05)。术后3个月试验组并发症发生率明显低于对照组(P<0.05),试验组术后骨折不愈合率低于对照组(P<0.05)。结论对股骨粗隆间骨折PFNA术后患者应用中药治疗促进患者康复,有效缓解疼痛,促进髋关节功能恢复,降低术后并发症发生风险,促进骨折愈合。

Ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris based on data mining

Objective To explore ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris, and to provide new ideas for the clinical treatment.Methods With “angina pectoris” as the key word, ancient books prescriptions and Chinese patent medicines related to angina pectoris were collected from China National Knowledge Infrastructure(CNKI), Traditional Chinese Medicine Database System, Chinese Medicine Prescription Database, New National Proprietary Chinese Medicine(2 nd edition), and Chinese Pharmacopoeia(2020 edition) from January 1, 2015 to December 31, 2021. Core highfrequency aromatic Chinese medicines were defined, and their potential medication rules were analyzed and summarized. Microsoft Access 2010 was used for data management. Data analysis software, including Excel and IBM SPSS Modeler 18.0 were used for drug association rule analysis, and Cytoscape 3.7.2 for visual display.Results There were 67 ancient books prescriptions and 258 Chinese patent medicines containing aromatic Chinese medicines treating angina pectoris collected from relevant databases. In ancient books prescriptions, there were nine aromatic Chinese medicines with the frequency ≥10, and the most commonly used medicine was Danggui(Angelicae Sinensis Radix), followed by Chenpi(Citri Reticulatae Pericarpium). There were 33 aromatic Chinese medicines with the frequency ≥10 in Chinese patent medicines, and the most commonly used medicine was Danshen(Salviae Miltiorrhizae Radix et Rhizoma), followed by Chuanxiong(Chuanxiong Rhizoma) and Sanqi(Notoginseng Radix et Rhizoma). In ancient books prescriptions, the medicines mainly belonged to intenal-warming medicines, Qi-regulating medicines, and blood circulation promoting and blood stasis removing medicines.There were eight medicine pairs with confidence equal to 100% in ancient books prescriptions, the most frequently used pairs were Chuanxiong(Chuanxiong Rhizoma) +Danggui(Angelicae Sinensis Radix), and Xiangfu(Cyperi Rhizoma) + Chenpi(Citri Reticulatae Pericarpium). In Chinese patent medicines, the aromatic Chinese medicine Chuanxiong(Chuanxiong Rhizoma) could be combined with many other Chinese medicines, among which the Confidence and Support of Chuanxiong(Chuanxiong Rhizoma) + Danshen(Salviae Miltiorrhizae Radix et Rhizoma) were at a high level.Conclusion Aromatic Chinese medicines for the treatment of angina pectoris of coronary heart disease are mainly warm, and the flavors are mainly pungent, sweet, and bitter. They mainly access to the liver, gallbladder, and pericardium meridians. The treatment of angina pectoris of coronary heart disease mainly focuses on warming heart pulse, and promoting blood circulation and removing blood stasis.