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^(131)I标记复合靶向基因载体对人脑胶质瘤U251细胞恶性生物学行为的影响
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作者 张玉娜 翟士军 罗阳子 《医药论坛杂志》 2022年第15期11-14,共4页
目的考察^(131)I标记复合靶向基因载体对人脑胶质瘤U251细胞恶性生物学行为的影响。方法选取U251细胞为研究对象,随机分为对照组与观察组两个组别。对照组细胞转入空白载体,观察组细胞中则载入^(131)I标记复合靶向基因载体。对两组细胞... 目的考察^(131)I标记复合靶向基因载体对人脑胶质瘤U251细胞恶性生物学行为的影响。方法选取U251细胞为研究对象,随机分为对照组与观察组两个组别。对照组细胞转入空白载体,观察组细胞中则载入^(131)I标记复合靶向基因载体。对两组细胞的载体转染情况、细胞迁移、侵袭能力、黏附能力及相关基因表达情况进行分析。结果^(131)I的纳米载体最终标记率为71%~85%,放化纯度为98.6%~99.2%;观察组U251细胞的增殖速率明显低于对照组,差异具有统计学意义(P<0.05);观察组中U251细胞转移、侵袭能力明显低于对照组,差异具有统计学意义(P<0.05);观察组中U251细胞的黏附能力明显低于对照组,差异具有统计学意义(P<0.05);观察组细胞中与肿瘤转移相关的基因明显下调。结论^(131)I标记复合靶向基因载体能够在一定程度上改善人脑胶质瘤U251细胞恶性生物学行为,抑制U251细胞的迁移及侵袭,降低其黏附力,对相关疾病的治疗具有一定的指导意义。 展开更多
关键词 ^(131)I 靶向基因载体 人脑胶质瘤 U251细胞 恶性生物学行为
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Compressed sensing based deconvolution algorithm for time-domain UWB channel modeling 被引量:1
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作者 LI De-jian LI Bin +1 位作者 ZHOU Zheng zhai shi-jun 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2012年第1期62-68,共7页
Extracting the parameters of the multipath with high accuracy can be achieved by using high-resolution algorithm for time-domain ultra wideband (UWB) channel modeling. The CLEAN algorithm has been used as such a hig... Extracting the parameters of the multipath with high accuracy can be achieved by using high-resolution algorithm for time-domain ultra wideband (UWB) channel modeling. The CLEAN algorithm has been used as such a high-resolution algorithm for UWB time-domain characterization. This paper presents a compressed sensing (CS) based high-resolution deconvolution algorithm for time-domain UWB channel modeling. UWB wireless channels are a prime example of long and sparse channel impulse response (CIR). Furthermore, the dictionary of parameterized waveforms that closely matches the waveform of multipath leads to that the UWB channel measurement signal is more compactly represented. By adjusting the parameter of dictionary, CIRs of different resolutions can be obtained. The matching pursuit (MP) algorithm is used as the signal reconstruction method for CS and outputs the CIR directly. We also demonstrated that if the dictionary of CS is designed specifically, MP is an equivalent of single template CLEAN. Finally, the computation complexity of CS-MP is analyzed and comparison of MP and CLEAN is performed. Simulation results show that compared to CLEAN, the proposed CS-MP deconvolution algorithm can achieve a comparable performance with much fewer samplings. 展开更多
关键词 compressed sensing DECONVOLUTION channel modeling matching pursuit UWB
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