Earthquakes can cause widely distributed slope failures and damage in mountainous areas.The accurate prediction of ground motions in mountainous areas is essential for managing the seismic risk of urban cities near mo...Earthquakes can cause widely distributed slope failures and damage in mountainous areas.The accurate prediction of ground motions in mountainous areas is essential for managing the seismic risk of urban cities near mountains but is restricted primarily by complex seismic site amplification effects in areas of uneven terrain.This study selected Qiaozhuang town located in the Qingchuan–Pingwu fault zone,Southwest China,as a case study.A simulator for mapped seismic responses using a hybrid model(Si Se RHMap)was applied to compute the multispectral seismic topographic amplification maps at the three slope units surrounding Qiaozhuang town(Weigan hill,Mt.Dong,and Mt.Shizi).Post-earthquake damage survey maps,1 D seismic site response spectral ratios,and H/V spectral ratios of earthquake data were used to validate the computed seismic site amplification factors and resonance frequencies.The results suggest that strong topographic amplification effects usually occur at distinct slope locations,such as hilltops,convex slope positions,upslope,and narrow ridges.The computed topographic amplification factors in the study area reached up to 2.4 at upslope or hilltops,and the resonance frequencies were between 3 and 10 Hz.Topographic effects can be as important as stratigraphic effects when assessing seismic amplification effects in the study area.We conclude that both topographic and stratigraphic effects should be considered in the comprehensive seismic hazard assessment of the study area or other similar mountain towns.展开更多
Background Accurate evaluation of response following chemotherapy treatment is essential for surgical decision making in patients with breast cancer. Modalities that have been used to monitor response to neo-adjuvant ...Background Accurate evaluation of response following chemotherapy treatment is essential for surgical decision making in patients with breast cancer. Modalities that have been used to monitor response to neo-adjuvant chemotherapy （NAC） include physical examination （PE）, ultrasound （US）, and magnetic resonance imaging （MRI）. The purpose of this study was to evaluate the accuracy of PE, US, and MRI in predicting the response to NAC in patients with breast cancer. Methods According to the response evaluation criteria in solid tumors guidelines, the largest unidimensional measurement of the tumor diameter evaluated by PE, US, and MRI before and after NAC was classified into four grades, including clinical complete response, clinical partial response, clinical progressive disease, clinical stable disease, and compared with the final histopathological examination. Results Of the 64 patients who received NAC, the pathologic complete response （pCR） was shown in 13 of 64 patients （20%）. The sensitivity of PE, US, and MRI in predicting the major pathologic response was 73%, 75%, and 80%, respectively, and the specificity was 45%, 50%, and 50% respectively. For predicting a pCR, the sensitivity of PE, US, and MRI was 46%, 46%, and 39%, respectively, and the specificity was 65%, 98%, and 92% respectively. Conclusions Compared with final pathologic findings, all these three clinical and imaging modalities tended to obviously underestimate the pCR rate. A more appropriate, universal, and practical standard by clinical and imaging modalities in predicting the response to neo-adjuvant chemotherapy in vivo is essential.展开更多
基金financially supported by the Funds for Creative Research Groups of China(Grant No.41521002)the National Natural Science Foundation of China(Grant No.42077257)the Open Fund of the State Key Laboratory of Geohazard Prevention and Geoenvironment Protection(Grants No.SKLGP2019K024 and No.SKLGP2019K006 assigned for G.Grelle’s competition proposal)。
文摘Earthquakes can cause widely distributed slope failures and damage in mountainous areas.The accurate prediction of ground motions in mountainous areas is essential for managing the seismic risk of urban cities near mountains but is restricted primarily by complex seismic site amplification effects in areas of uneven terrain.This study selected Qiaozhuang town located in the Qingchuan–Pingwu fault zone,Southwest China,as a case study.A simulator for mapped seismic responses using a hybrid model(Si Se RHMap)was applied to compute the multispectral seismic topographic amplification maps at the three slope units surrounding Qiaozhuang town(Weigan hill,Mt.Dong,and Mt.Shizi).Post-earthquake damage survey maps,1 D seismic site response spectral ratios,and H/V spectral ratios of earthquake data were used to validate the computed seismic site amplification factors and resonance frequencies.The results suggest that strong topographic amplification effects usually occur at distinct slope locations,such as hilltops,convex slope positions,upslope,and narrow ridges.The computed topographic amplification factors in the study area reached up to 2.4 at upslope or hilltops,and the resonance frequencies were between 3 and 10 Hz.Topographic effects can be as important as stratigraphic effects when assessing seismic amplification effects in the study area.We conclude that both topographic and stratigraphic effects should be considered in the comprehensive seismic hazard assessment of the study area or other similar mountain towns.
文摘Background Accurate evaluation of response following chemotherapy treatment is essential for surgical decision making in patients with breast cancer. Modalities that have been used to monitor response to neo-adjuvant chemotherapy （NAC） include physical examination （PE）, ultrasound （US）, and magnetic resonance imaging （MRI）. The purpose of this study was to evaluate the accuracy of PE, US, and MRI in predicting the response to NAC in patients with breast cancer. Methods According to the response evaluation criteria in solid tumors guidelines, the largest unidimensional measurement of the tumor diameter evaluated by PE, US, and MRI before and after NAC was classified into four grades, including clinical complete response, clinical partial response, clinical progressive disease, clinical stable disease, and compared with the final histopathological examination. Results Of the 64 patients who received NAC, the pathologic complete response （pCR） was shown in 13 of 64 patients （20%）. The sensitivity of PE, US, and MRI in predicting the major pathologic response was 73%, 75%, and 80%, respectively, and the specificity was 45%, 50%, and 50% respectively. For predicting a pCR, the sensitivity of PE, US, and MRI was 46%, 46%, and 39%, respectively, and the specificity was 65%, 98%, and 92% respectively. Conclusions Compared with final pathologic findings, all these three clinical and imaging modalities tended to obviously underestimate the pCR rate. A more appropriate, universal, and practical standard by clinical and imaging modalities in predicting the response to neo-adjuvant chemotherapy in vivo is essential.
