Posttransplant lymphoproliferative disorder （PTLD） is a well-known complication of both solid organ and bone marrow transplantation, with a prevalence estimated to be between 1% to 20% depending on the type of organ...Posttransplant lymphoproliferative disorder （PTLD） is a well-known complication of both solid organ and bone marrow transplantation, with a prevalence estimated to be between 1% to 20% depending on the type of organ transplanted. PTLD includes a wide spectrum of proliferative changes ranging from reactive hyperplasia, borderline lesions, to malignant lymphomas. Several factors, such as the clinical immunosuppressive regimen, infection of the Epstein-Barr virus, and underlying disease in the patient are believed to contribute to the development of PTLD.展开更多
Congenital insensitivity to pain is a rare disorder, first described by Dearborn in 1932. Since the discovery of congenital insensitivity to pain with anhidrosis or hereditary sensory neuropathy type Ⅳ in 1983, fewer...Congenital insensitivity to pain is a rare disorder, first described by Dearborn in 1932. Since the discovery of congenital insensitivity to pain with anhidrosis or hereditary sensory neuropathy type Ⅳ in 1983, fewer than 60 cases have been reported. Congenital insensitivity to pain with anhidrosis and progressing acro-osteolysis is a very rare disorder characterized by absence of painful perception after birth. Severe problems may arise if pain sensation is absent, causing injury to oral structures as teeth, lips and the tongue by self mutilation. The patient is at a risk of late presentation with systemic illnesses associated with pain, such as fracture and joint dislocation. Importantly, the patient may suffer from acro-osteolysis with growth, for instance, osteolysis of the distal extremities.展开更多
基金This study was supported by a grant from the National Natural Science Foundation of China （No. 30600586）.
文摘Posttransplant lymphoproliferative disorder （PTLD） is a well-known complication of both solid organ and bone marrow transplantation, with a prevalence estimated to be between 1% to 20% depending on the type of organ transplanted. PTLD includes a wide spectrum of proliferative changes ranging from reactive hyperplasia, borderline lesions, to malignant lymphomas. Several factors, such as the clinical immunosuppressive regimen, infection of the Epstein-Barr virus, and underlying disease in the patient are believed to contribute to the development of PTLD.
文摘Congenital insensitivity to pain is a rare disorder, first described by Dearborn in 1932. Since the discovery of congenital insensitivity to pain with anhidrosis or hereditary sensory neuropathy type Ⅳ in 1983, fewer than 60 cases have been reported. Congenital insensitivity to pain with anhidrosis and progressing acro-osteolysis is a very rare disorder characterized by absence of painful perception after birth. Severe problems may arise if pain sensation is absent, causing injury to oral structures as teeth, lips and the tongue by self mutilation. The patient is at a risk of late presentation with systemic illnesses associated with pain, such as fracture and joint dislocation. Importantly, the patient may suffer from acro-osteolysis with growth, for instance, osteolysis of the distal extremities.
