Objective:To observe the anticoagulant effect of local citrate anticoagulation and non-anticoagulation in prolonged intermittent renal replacement therapy(PITTR).Methods:From October 2018 to October 2019,30 patients w...Objective:To observe the anticoagulant effect of local citrate anticoagulation and non-anticoagulation in prolonged intermittent renal replacement therapy(PITTR).Methods:From October 2018 to October 2019,30 patients with a high risk of bleeding who received PIRRT treatment in our hospital were selected and divided into RCA group(citrate group)and control group(non-anticoagulant group),15 cases in each group.The anticoagulant efficiency,filter service life,coagulation function,and blood gas indexes were compared between the two groups.Results:(1)the anticoagulant effective rate of the RCA group was higher than that of the control group,and the use time of the filter was longer than that of the control group(P<0.05).(2)There was no significant difference in Pt and APTT between the two groups before and after treatment(P>0.05).(3)There was no significant difference in plasma calcium concentration between the two groups before treatment,4,6 and 8 h after treatment(P>0.05).(4)In the RCA group,the pH value and be valued at 4,6 and 8 h after treatment were higher than those before treatment,but they were in the normal range,and the difference was statistically significant(P<0.05).Conclusion:In the extended intermittent renal replacement therapy,the effect of local citrate anticoagulation is better than that of non-anticoagulant therapy,which can prolong the service life of the filter,and there are no adverse reactions such as prolonged coagulation time,hypocalcemia,and metabolic acid-base imbalance.展开更多
文摘Objective:To observe the anticoagulant effect of local citrate anticoagulation and non-anticoagulation in prolonged intermittent renal replacement therapy(PITTR).Methods:From October 2018 to October 2019,30 patients with a high risk of bleeding who received PIRRT treatment in our hospital were selected and divided into RCA group(citrate group)and control group(non-anticoagulant group),15 cases in each group.The anticoagulant efficiency,filter service life,coagulation function,and blood gas indexes were compared between the two groups.Results:(1)the anticoagulant effective rate of the RCA group was higher than that of the control group,and the use time of the filter was longer than that of the control group(P<0.05).(2)There was no significant difference in Pt and APTT between the two groups before and after treatment(P>0.05).(3)There was no significant difference in plasma calcium concentration between the two groups before treatment,4,6 and 8 h after treatment(P>0.05).(4)In the RCA group,the pH value and be valued at 4,6 and 8 h after treatment were higher than those before treatment,but they were in the normal range,and the difference was statistically significant(P<0.05).Conclusion:In the extended intermittent renal replacement therapy,the effect of local citrate anticoagulation is better than that of non-anticoagulant therapy,which can prolong the service life of the filter,and there are no adverse reactions such as prolonged coagulation time,hypocalcemia,and metabolic acid-base imbalance.
