A new di-nuclear ruthenium arene compound containing thiosemicarbazone ligands, [Ru(η6-cymene)(TSC)Cl]2(PF6)2(2), was synthesized and characterized by 1H NMR, HR-ESI-MS, and elemental analysis. Furthermore, the compl...A new di-nuclear ruthenium arene compound containing thiosemicarbazone ligands, [Ru(η6-cymene)(TSC)Cl]2(PF6)2(2), was synthesized and characterized by 1H NMR, HR-ESI-MS, and elemental analysis. Furthermore, the complete structure of 2 was determined by single-crystal X-ray diffraction analysis. Density functional theory(DFT) calculations with B3LYP functional and LANL2DZ(for Ru)/6-31G*(for other atoms) basis sets were carried out for the reactions involving complexes 1 and 2 in order to understand the formation of the complexes. The in vitro anticancer activities of the compound were investigated against five human cancer cell lines(SGC-7901, CNE-2, HepG2, KB and HeLa), and the IC50 values are 39.5, 45.8, 49.8, 54.5 and 61.8 μM, respectively.展开更多
基金supported by the National Natural Science Foundation of China (51961009,21761006)Natural Science Foundation of Guangxi Province (2017GXNSFAA198335,2018GXNSFAA281345)+5 种基金Guangxi Scientific and Technological Development Projects (AD17195081)“BAGUI Scholar” Program of Guangxi ProvinceNatural Science Foundation of Guangxi University of Chinese Medicine (2017JQ001)Guangxi First-class Discipline Chinese Materia Medica (Scientific Research of Guangxi Education Department 2018 No. 12)Research Project of Guangxi First-class Discipline (2019XK135)Project of Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine (GXZYZZ2019-4)。
文摘A new di-nuclear ruthenium arene compound containing thiosemicarbazone ligands, [Ru(η6-cymene)(TSC)Cl]2(PF6)2(2), was synthesized and characterized by 1H NMR, HR-ESI-MS, and elemental analysis. Furthermore, the complete structure of 2 was determined by single-crystal X-ray diffraction analysis. Density functional theory(DFT) calculations with B3LYP functional and LANL2DZ(for Ru)/6-31G*(for other atoms) basis sets were carried out for the reactions involving complexes 1 and 2 in order to understand the formation of the complexes. The in vitro anticancer activities of the compound were investigated against five human cancer cell lines(SGC-7901, CNE-2, HepG2, KB and HeLa), and the IC50 values are 39.5, 45.8, 49.8, 54.5 and 61.8 μM, respectively.
