A convenient and efficient procedure for the synthesis ofN, N-bicyclic pyrazolidinone derivatives has been developed via the reaction of azomethine imines with terminal alkynes under the ball milling condition without...A convenient and efficient procedure for the synthesis ofN, N-bicyclic pyrazolidinone derivatives has been developed via the reaction of azomethine imines with terminal alkynes under the ball milling condition without sol- vent, which was promoted by calcium fluoride with a catalyst of copper（I） salt. The cyclization reactions exhibited moderate to high yields.展开更多
基金Supported by the National Natural Science Foundation of China（Nos.21261008, 21471069）, the Special Integration Fund of Industry and Research of Hainan Province, China（No.CXY20130010）, the Natural Science Foundation of Hainan Province, China（No.213014） and the International Science and Technology Cooperation Projects of Hainan Province, China（No. KJI-IZ2014-05）.
文摘A convenient and efficient procedure for the synthesis ofN, N-bicyclic pyrazolidinone derivatives has been developed via the reaction of azomethine imines with terminal alkynes under the ball milling condition without sol- vent, which was promoted by calcium fluoride with a catalyst of copper（I） salt. The cyclization reactions exhibited moderate to high yields.
