Interactions of Vitamin D Receptor Polymorphisms with Hypertriglyceridemia and Obesity in Chinese Individuals Susceptible to Hypertension and Diabetes Comorbidity

Hypertension(HTN)and type 2 diabetes mellitus(T2DM)are interconnected metabolic diseases[1,2]that considerably increase susceptibility to microvascular and macrovascular disorders.In many patients,HTN and diabetes comorbidity(HDC)is caused by mutual pathogenic pathways,such as endothelial dysfunction,atherosclerosis,oxidative stress,and vascular inflammation[1].Hence.

Association of VDR Gene Variants with Hyperglycemia in Henan Rural Population

The term hyperglycemia was used to defined an abnormal status in which blood glucose increases and deviates from the normal fasting glucose(NFG),which contains the following statuses:impaired fasting glucose(IFG),impaired glucose tolerance(IGT),and diabetes mellitus(DM).

Polymorphisms in CYP2R1 Gene Associated with Serum Vitamin D Levels and Status in a Chinese Rural Population

Vitamin D, a fat-soluble vitamin and endocrine horm one, and it impacts various bone and extra-bone health, such as osteoporosis, diabetes, and cancer. The main circulating form of vitamin D is 25-hydroxyvitamin D [25(OH)D] and it is a useful clinical biomarker of vitamin D status. The Institute of Medicine (IOM) defines as vitamin D deficiency (VDD) when serum 25(OH)D concentration is less than 20 ng/mL⑴.Worldwide, VDD is recognized as a severe public health problem. In 2007, Holick estimated that globally over one billion people suffered from VDD or vitamin D insufficiency (VDI). In China, it has bee n reported that the prevale nee of VDD ranged from 38.8% to 91.2% in different regions.

Association of Serum Vitamin D Status and Waist Circumference on Obesity with Type 2 Diabetes:A Cross-sectional Study in Rural Adults of Henan

Obesity and T2 DM have now become serious epidemics in public health issues worldwide.T2 DM is considered a multifactorial disease,which is promoted by genetic and environmental factors and characterized by chronic hyperglycemia and insulin resistance(IR).According to the report of the World Health Organization,overweight and obesity account for 44%of diabetes cases in most European countries;overweight and obesity are also responsible for about 80%of T2 DM cases.

Association of Serum Glucocorticoids with Various Blood Pressure Indices in Patients with Dysglycemia and Hypertension:the Henan Rural Cohort Study

Objective To our knowledge, no definitive conclusion has been reached regarding the relationship between glucocorticoids and hypertension. Here, we aimed to explore the characteristics of glucocorticoids in participants with dysglycemia and hypertension, and to analyze their association with blood pressure indicators.Methods The participants of this study were from the Henan Rural Cohort study. A total of 1,688 patients 18–79 years of age were included in the matched case control study after application of the inclusion and exclusion criteria. Statistical methods were used to analyze the association between glucocorticoids and various indices of blood pressure, through approaches such as logistic regression analysis, trend tests, linear regression, and restricted cubic regression.Results The study population consisted of 552 patients with dysglycemia and hypertension(32.7%).The patients with co-morbidities had higher levels of serum cortisol(P = 0.009) and deoxycortisol(P <0.001). The adjusted odds ratios(and 95% confidence intervals) for dysglycemia with hypertension were1.55(1.18, 2.04) for the highest tertile of Ln-cortisol compared with the lowest tertile. Additionally, the highest Ln-deoxycortisol levels were associated with increased prevalence of dysglycemia with hypertension by 159%(95% confidence interval: 122%, 207%).Conclusions Serum deoxycortisol was positively correlated with systolic blood pressure, pulse pressure, mean arterial pressure, mean blood pressure, and mean proportional arterial pressure.Glucocorticoids(deoxycortisol and cortisol) increase the risk of hypertension in people with dysglycemia, particularly in those with T2 DM.

Association of VDR Polymorphisms and Gene-obesity Interaction with Type 2 Diabetes:A Case-control Study among Chinese Rural Population

In recent years,the prevalence of type 2 diabetes(T2D)has increased at an alarming rate,and the epidemic of T2D mellitus and its complications poses a major global health threat.Globally,the International Diabetes Federation estimated that 10.5% of adults aged 20-79 years(536 million adults)had diabetes mellitus in 2021.