为了解国内外慢性病经济毒性研究领域现状与热点,检索Web of Science数据库和中国知网近10年相关文献,运用CiteSpace进行可视化分析。发现美国发文量居于首位,我国排名第2;国外机构合作较紧密,国内多为独立状态;该领域作者合作较少,仅...为了解国内外慢性病经济毒性研究领域现状与热点,检索Web of Science数据库和中国知网近10年相关文献,运用CiteSpace进行可视化分析。发现美国发文量居于首位,我国排名第2;国外机构合作较紧密,国内多为独立状态;该领域作者合作较少,仅核心作者存在合作;国内聚焦老年人、农村、乙型肝炎、医疗费用等;国外聚焦成年人、照护者、慢性肾病、生活质量、心理健康等。与国外相比,我国慢性病经济毒性研究起步晚,可借鉴国外经验,建立适合我国国情的照护者体系,聚焦个人或家庭系统,剖析慢性病及其治疗带来的财务冲击,减少经济毒性对慢性病患者的影响。展开更多
目的:现有研究显示,原发性痛风和高尿酸血症是一类多基因遗传性疾病,是遗传因素和环境因素共同作用的结果。但目前对痛风和高尿酸血症的遗传易感性研究尚不完善,还不能预测哪些人群易患痛风和高尿酸血症。全基因组关联分析(Genome-wide ...目的:现有研究显示,原发性痛风和高尿酸血症是一类多基因遗传性疾病,是遗传因素和环境因素共同作用的结果。但目前对痛风和高尿酸血症的遗传易感性研究尚不完善,还不能预测哪些人群易患痛风和高尿酸血症。全基因组关联分析(Genome-wide association study,GWAS)是近年来发展起来的用于识别、鉴定复杂性疾病致病易感基因的手段,通过对病人和正常对照人群的筛查,结合计算机技术和统计分析手段,可从整个基因组变异来识别、鉴定微效基因及其与相关疾病的相互作用。笔者对近几年发现的尿酸相关基因进行总结分类,为进一步认识痛风和高尿酸血症的分子机制提供依据,为进一步深入研究痛风和高尿酸血症的病因提供有益参考。展开更多
随着新能源大规模接入以及负荷的随机波动性,对配电网的电能质量提出了更高的挑战及要求。主动配电网控制无功调压设备抑制电压波动通常转化为混合整数规划问题,难以做到实时控制且需频繁进行复杂计算。从历史数据中提取源荷状态,生成...随着新能源大规模接入以及负荷的随机波动性,对配电网的电能质量提出了更高的挑战及要求。主动配电网控制无功调压设备抑制电压波动通常转化为混合整数规划问题,难以做到实时控制且需频繁进行复杂计算。从历史数据中提取源荷状态,生成基于二阶锥最优潮流模型的电压控制策略,构建以调压装置状态、系统数据与控制策略为核心实体的配电网电压控制知识图谱;在实时电压控制时,基于时间序列相似度检索算法,以当前网络状态匹配知识图谱中相似状态,进行安全校验和优化求解,并更新知识图谱中的状态策略。同时,在无功设备调节过程中增加人机交互环节,对于时间尺度、电压及设备动作及关键点电压实现精准控制。基于改进电气电子工程师学会(Institute of Electrical and Electronics Engineers,IEEE)系统算例的仿真结果表明,所提出的基于电压控制策略知识图谱的检索方法及交互策略能够有效提升配电网无功电压控制策略生成效率,并具有不同场景适用性。展开更多
The stereospecific hydrolysis of mandelate can be effectively catalyzed by hyperthermophilic acylpeptide esterase APE 1547（Aeropyrum pernix esterase 1547）. APE 1547 used in this reaction showed a remarkable stereodi...The stereospecific hydrolysis of mandelate can be effectively catalyzed by hyperthermophilic acylpeptide esterase APE 1547（Aeropyrum pernix esterase 1547）. APE 1547 used in this reaction showed a remarkable stereodi-scrimination in favour of R-mandelic acid（99% e.e.） with an enantiomeric ratio E〉200. The results of computer simulation are consistent with the experimental results. It can be inferred that the R-substrate adopted a binding mode productive of the reaction due to the formation of the hydrogen bond at the active site of APE 1547.展开更多
Objective:Existing studies have shown that primary gout and hyperuricemia are a group of polygenetic hereditary diseases,which are the results of the combination of genetic and environmental factors.However,the study ...Objective:Existing studies have shown that primary gout and hyperuricemia are a group of polygenetic hereditary diseases,which are the results of the combination of genetic and environmental factors.However,the study on the genetic susceptibility of gout and hyperuricemia is not yet complete and it is not yet possible to predict which populations are susceptible to gout and hyperuricemia.Genome-wide association study(GWAS),a method developed in recent years,is used to identify susceptibility genes for complex disease pathogenesis.Through screening patients and the normal control,and combined with computer technology and statistical analysis,genome-wide variation can be used to identify minor gene and its interaction with related diseases.In our study,we summarized and classified uric acid related genes discovered in recent years,so as to provide a basis for further understanding of the molecular mechanism of gout and hyperuricemia,and provide a beneficial reference for further study on the etiology of gout and hyperuricemia.展开更多
文摘为了解国内外慢性病经济毒性研究领域现状与热点,检索Web of Science数据库和中国知网近10年相关文献,运用CiteSpace进行可视化分析。发现美国发文量居于首位,我国排名第2;国外机构合作较紧密,国内多为独立状态;该领域作者合作较少,仅核心作者存在合作;国内聚焦老年人、农村、乙型肝炎、医疗费用等;国外聚焦成年人、照护者、慢性肾病、生活质量、心理健康等。与国外相比,我国慢性病经济毒性研究起步晚,可借鉴国外经验,建立适合我国国情的照护者体系,聚焦个人或家庭系统,剖析慢性病及其治疗带来的财务冲击,减少经济毒性对慢性病患者的影响。
文摘目的:现有研究显示,原发性痛风和高尿酸血症是一类多基因遗传性疾病,是遗传因素和环境因素共同作用的结果。但目前对痛风和高尿酸血症的遗传易感性研究尚不完善,还不能预测哪些人群易患痛风和高尿酸血症。全基因组关联分析(Genome-wide association study,GWAS)是近年来发展起来的用于识别、鉴定复杂性疾病致病易感基因的手段,通过对病人和正常对照人群的筛查,结合计算机技术和统计分析手段,可从整个基因组变异来识别、鉴定微效基因及其与相关疾病的相互作用。笔者对近几年发现的尿酸相关基因进行总结分类,为进一步认识痛风和高尿酸血症的分子机制提供依据,为进一步深入研究痛风和高尿酸血症的病因提供有益参考。
文摘随着新能源大规模接入以及负荷的随机波动性,对配电网的电能质量提出了更高的挑战及要求。主动配电网控制无功调压设备抑制电压波动通常转化为混合整数规划问题,难以做到实时控制且需频繁进行复杂计算。从历史数据中提取源荷状态,生成基于二阶锥最优潮流模型的电压控制策略,构建以调压装置状态、系统数据与控制策略为核心实体的配电网电压控制知识图谱;在实时电压控制时,基于时间序列相似度检索算法,以当前网络状态匹配知识图谱中相似状态,进行安全校验和优化求解,并更新知识图谱中的状态策略。同时,在无功设备调节过程中增加人机交互环节,对于时间尺度、电压及设备动作及关键点电压实现精准控制。基于改进电气电子工程师学会(Institute of Electrical and Electronics Engineers,IEEE)系统算例的仿真结果表明,所提出的基于电压控制策略知识图谱的检索方法及交互策略能够有效提升配电网无功电压控制策略生成效率,并具有不同场景适用性。
基金Supported by the National Natural Science Foundation of China(Nos.30870539, 21072075)the 38th Postdoctoral Foundation of China(No.801050321413)
文摘The stereospecific hydrolysis of mandelate can be effectively catalyzed by hyperthermophilic acylpeptide esterase APE 1547（Aeropyrum pernix esterase 1547）. APE 1547 used in this reaction showed a remarkable stereodi-scrimination in favour of R-mandelic acid（99% e.e.） with an enantiomeric ratio E〉200. The results of computer simulation are consistent with the experimental results. It can be inferred that the R-substrate adopted a binding mode productive of the reaction due to the formation of the hydrogen bond at the active site of APE 1547.
基金This study was supported by the Project of Heilongjiang Natural Science Fund(Grant No.H201374)Basic Scientific Research Business Fee Project of Heilongjiang Provincial Universities(Grant No.2016-KYYWF-0591)Graduate Student Innovation Project of Jiamusi University(BC2016_001).
文摘Objective:Existing studies have shown that primary gout and hyperuricemia are a group of polygenetic hereditary diseases,which are the results of the combination of genetic and environmental factors.However,the study on the genetic susceptibility of gout and hyperuricemia is not yet complete and it is not yet possible to predict which populations are susceptible to gout and hyperuricemia.Genome-wide association study(GWAS),a method developed in recent years,is used to identify susceptibility genes for complex disease pathogenesis.Through screening patients and the normal control,and combined with computer technology and statistical analysis,genome-wide variation can be used to identify minor gene and its interaction with related diseases.In our study,we summarized and classified uric acid related genes discovered in recent years,so as to provide a basis for further understanding of the molecular mechanism of gout and hyperuricemia,and provide a beneficial reference for further study on the etiology of gout and hyperuricemia.
