At the National Science and Technology Awards Conference held in January, 2017, a project from Lianyungang attracts attention particularly. This project of "the key technology and application of dry-jet wetspinni...At the National Science and Technology Awards Conference held in January, 2017, a project from Lianyungang attracts attention particularly. This project of "the key technology and application of dry-jet wetspinning thousand-ton展开更多
透明质酸(hyaluronan,HA)是细胞外基质的重要成分,在肿瘤间质中异常潴留,参与肿瘤微环境的重构。据报道,HA及其相关代谢酶、受体与肿瘤细胞可塑性改变密切相关,在肿瘤干细胞干性维持、上皮-间充质转换(epithelial to mesenchymal transi...透明质酸(hyaluronan,HA)是细胞外基质的重要成分,在肿瘤间质中异常潴留,参与肿瘤微环境的重构。据报道,HA及其相关代谢酶、受体与肿瘤细胞可塑性改变密切相关,在肿瘤干细胞干性维持、上皮-间充质转换(epithelial to mesenchymal transition,EMT)、获得性耐药等过程中均发挥重要的调节作用。本文对HA在调节肿瘤细胞可塑性中作用的研究进展进行了综述。展开更多
文摘At the National Science and Technology Awards Conference held in January, 2017, a project from Lianyungang attracts attention particularly. This project of "the key technology and application of dry-jet wetspinning thousand-ton
文摘透明质酸(hyaluronan,HA)是细胞外基质的重要成分,在肿瘤间质中异常潴留,参与肿瘤微环境的重构。据报道,HA及其相关代谢酶、受体与肿瘤细胞可塑性改变密切相关,在肿瘤干细胞干性维持、上皮-间充质转换(epithelial to mesenchymal transition,EMT)、获得性耐药等过程中均发挥重要的调节作用。本文对HA在调节肿瘤细胞可塑性中作用的研究进展进行了综述。