Mitochondria are important intracellular organelles that carry out oxidative phosphorylation,synthesize ATP,and provide energy for cell activities.Mitochondrial dysfunction can affect the normal function of the entire...Mitochondria are important intracellular organelles that carry out oxidative phosphorylation,synthesize ATP,and provide energy for cell activities.Mitochondrial dysfunction can affect the normal function of the entire cell and is thought to be a major risk factor in the onset and progression of some diseases associated with chronic inflammation and insulin resistance[1].展开更多
The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We...The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite‐converted DNA. We have identified many differentially methylated Cp G sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin‐signaling pathway（ISP）, adipocytokine signaling pathway（ASP） and MAPK signaling pathway are involved in the fetal programming of diabetes.展开更多
基金supported by the grants from National Natural Science Foundation of China[Grants No.31371191]Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences[CIFMS2017-I2M-1-008,CIFMS2021-1-I2M-016]。
文摘Mitochondria are important intracellular organelles that carry out oxidative phosphorylation,synthesize ATP,and provide energy for cell activities.Mitochondrial dysfunction can affect the normal function of the entire cell and is thought to be a major risk factor in the onset and progression of some diseases associated with chronic inflammation and insulin resistance[1].
基金supported by the National Natural Science Foundation of China(NSFC),project number is 81170736 and 81570715
文摘The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite‐converted DNA. We have identified many differentially methylated Cp G sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin‐signaling pathway（ISP）, adipocytokine signaling pathway（ASP） and MAPK signaling pathway are involved in the fetal programming of diabetes.
