目的分析初诊弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者的心电图特征。方法回顾性收集在天津医科大学附属肿瘤医院病理诊断确诊为DLBCL的90例患者的病例资料,记录抗肿瘤治疗开始前患者临床特征、异常心电图发生率...目的分析初诊弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者的心电图特征。方法回顾性收集在天津医科大学附属肿瘤医院病理诊断确诊为DLBCL的90例患者的病例资料,记录抗肿瘤治疗开始前患者临床特征、异常心电图发生率,并手工测量相关基线心电图指标。结果研究人群中位及四分位间距年龄为58(16)岁,其中男53例(58.9%),女37例(41.1%)。既往合并疾病中高血压比例最高(n=25,27.8%),其次是糖尿病(n=13,14.4%)。共54例(60.0%)患者存在基线心电图异常,其中ST-T改变32例(35.6%)最为常见。基线心电图指标统计结果如下:心率(83±17)次/min、P波时限(104.6±11.0)ms、P波振幅(0.13±0.04)m V、V1导联P波终末电势(-0.010±0.011)mm·s、P波离散度(37.0±10.1)ms、PR间期(149±23)ms、QRS时限(89.3±16.4)ms、QRS电轴46.0°±35.1°、校正QT间期(417.6±61.5)ms、QT离散度(43±16)ms、T波波峰至T波终点时限(86±21)ms、心脏电生理平衡指数4.0±0.8。结论初诊DLBCL患者合并心血管疾病患病率高,半数以上患者合并心电图异常,心电图指标相对正常,临床上应高度关注。展开更多
采用PFC2D颗粒流软件提出了一种新的生成初始土层模型的方法(Multi-layer and Multi-gravity Compaction Method即MGCM),可以得到较合理的初始土层应力分布。从细观力学的角度对柔性填料法涵洞减载进行了数值模拟,研究了不同填土高度下...采用PFC2D颗粒流软件提出了一种新的生成初始土层模型的方法(Multi-layer and Multi-gravity Compaction Method即MGCM),可以得到较合理的初始土层应力分布。从细观力学的角度对柔性填料法涵洞减载进行了数值模拟,研究了不同填土高度下涵顶土压力系数的变化规律,及内外土柱相对位移对涵洞上方和两侧受载的影响。研究结果表明:涵顶土压力系数随着填土高度的增加逐渐增加,当填土达到一定高度后其值趋于稳定并略有降低。随着内外土柱相对位移的增加,涵洞上方土层接触力链逐渐发展成拱形状,涵侧土压力逐渐增大,但增幅逐渐减小;涵顶土压力逐渐减小后趋于稳定并略有上升。展开更多
Background There are no data on more tolerable capecitabine doses in elderly patients in Chinese population. The aim of this study was to evaluate the activity and safety of capecitabine combined with weekly docetaxel...Background There are no data on more tolerable capecitabine doses in elderly patients in Chinese population. The aim of this study was to evaluate the activity and safety of capecitabine combined with weekly docetaxel for the treatment of anthracycline-resistant metastatic breast cancer （MBC） in older Chinese patients. Methods MBC patients aged 〉65 years pretreated with 1-5 prior chemotherapy regimens, including an anthracycline, received oral capecitabine 825 mg/m^2 twice daily, days 1-14, plus docetaxel 30 mg/m^2 on days 1 and 8 every 21 days. All 41 enrolled patients received at least 1 dose of treatment and were evaluable for safety; 38 received at least 2 cycles （median 4, range 2-8） and were evaluable for efficacy. Results The overall objective response rate was 47%, including complete responses in 8% of patients. Median time to progression was 8.9 months. Median overall survival was 17.6 months. The most common side effects were haematological and gastrointestinal toxicities and hand-foot syndrome. The only grade 3/4 adverse events were neutropenia （12%）, alopecia （7%）, grade 3 nausea and vomiting （2%） and grade 3 nail toxicity （2%）. Conclusions Capecitabine 825 mg/m^2 twice daily plus weekly docetaxel is active with an acceptable safety profile in Chinese women 〉65 years with anthracycline-resistant MBC. Efficacy and tolerability compare favourably with previously reported trials evaluating higher capecitabine doses in combination with 3-weekly or weekly docetaxel.展开更多
文摘目的分析初诊弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者的心电图特征。方法回顾性收集在天津医科大学附属肿瘤医院病理诊断确诊为DLBCL的90例患者的病例资料,记录抗肿瘤治疗开始前患者临床特征、异常心电图发生率,并手工测量相关基线心电图指标。结果研究人群中位及四分位间距年龄为58(16)岁,其中男53例(58.9%),女37例(41.1%)。既往合并疾病中高血压比例最高(n=25,27.8%),其次是糖尿病(n=13,14.4%)。共54例(60.0%)患者存在基线心电图异常,其中ST-T改变32例(35.6%)最为常见。基线心电图指标统计结果如下:心率(83±17)次/min、P波时限(104.6±11.0)ms、P波振幅(0.13±0.04)m V、V1导联P波终末电势(-0.010±0.011)mm·s、P波离散度(37.0±10.1)ms、PR间期(149±23)ms、QRS时限(89.3±16.4)ms、QRS电轴46.0°±35.1°、校正QT间期(417.6±61.5)ms、QT离散度(43±16)ms、T波波峰至T波终点时限(86±21)ms、心脏电生理平衡指数4.0±0.8。结论初诊DLBCL患者合并心血管疾病患病率高,半数以上患者合并心电图异常,心电图指标相对正常,临床上应高度关注。
文摘采用PFC2D颗粒流软件提出了一种新的生成初始土层模型的方法(Multi-layer and Multi-gravity Compaction Method即MGCM),可以得到较合理的初始土层应力分布。从细观力学的角度对柔性填料法涵洞减载进行了数值模拟,研究了不同填土高度下涵顶土压力系数的变化规律,及内外土柱相对位移对涵洞上方和两侧受载的影响。研究结果表明:涵顶土压力系数随着填土高度的增加逐渐增加,当填土达到一定高度后其值趋于稳定并略有降低。随着内外土柱相对位移的增加,涵洞上方土层接触力链逐渐发展成拱形状,涵侧土压力逐渐增大,但增幅逐渐减小;涵顶土压力逐渐减小后趋于稳定并略有上升。
文摘Background There are no data on more tolerable capecitabine doses in elderly patients in Chinese population. The aim of this study was to evaluate the activity and safety of capecitabine combined with weekly docetaxel for the treatment of anthracycline-resistant metastatic breast cancer （MBC） in older Chinese patients. Methods MBC patients aged 〉65 years pretreated with 1-5 prior chemotherapy regimens, including an anthracycline, received oral capecitabine 825 mg/m^2 twice daily, days 1-14, plus docetaxel 30 mg/m^2 on days 1 and 8 every 21 days. All 41 enrolled patients received at least 1 dose of treatment and were evaluable for safety; 38 received at least 2 cycles （median 4, range 2-8） and were evaluable for efficacy. Results The overall objective response rate was 47%, including complete responses in 8% of patients. Median time to progression was 8.9 months. Median overall survival was 17.6 months. The most common side effects were haematological and gastrointestinal toxicities and hand-foot syndrome. The only grade 3/4 adverse events were neutropenia （12%）, alopecia （7%）, grade 3 nausea and vomiting （2%） and grade 3 nail toxicity （2%）. Conclusions Capecitabine 825 mg/m^2 twice daily plus weekly docetaxel is active with an acceptable safety profile in Chinese women 〉65 years with anthracycline-resistant MBC. Efficacy and tolerability compare favourably with previously reported trials evaluating higher capecitabine doses in combination with 3-weekly or weekly docetaxel.
