Asthma is a worldwide prevalent disease that is a .considerable health burden in many countries. In recent years, the airway epithelium is increasingly recognized as a central contributor to the pathogenesis of asthma...Asthma is a worldwide prevalent disease that is a .considerable health burden in many countries. In recent years, the airway epithelium is increasingly recognized as a central contributor to the pathogenesis of asthma. One of the most highly induced genes in epithelial ceils in experimental allergic airway disease is the third murine calcium-activated chloride channel homologue （mclca3, alias gob-5）. Its human homology protein is hCLCA, which has been identified as clinically relevant molecules in diseases with secretory dysfunctions including asthma and cystic fibrosis.展开更多
文摘Asthma is a worldwide prevalent disease that is a .considerable health burden in many countries. In recent years, the airway epithelium is increasingly recognized as a central contributor to the pathogenesis of asthma. One of the most highly induced genes in epithelial ceils in experimental allergic airway disease is the third murine calcium-activated chloride channel homologue （mclca3, alias gob-5）. Its human homology protein is hCLCA, which has been identified as clinically relevant molecules in diseases with secretory dysfunctions including asthma and cystic fibrosis.
