After establishing hemi-Parkinsonian rat models, the relationships between neuron death and the expression of several proteins, such as c-Fos, GFAP, GDNF, NF-κB and some cytokines were determined. Therapeutics experi...After establishing hemi-Parkinsonian rat models, the relationships between neuron death and the expression of several proteins, such as c-Fos, GFAP, GDNF, NF-κB and some cytokines were determined. Therapeutics experiments with notoginsenoside-Rg1 were carried out. The research results show that the expressions of GFAP, NF-Kκ and c-Fos will obviously increase in the lesion side of the striatum and the expression of GDNF will decrease, which implies that the signal transduction pathway may participate in the apoptosis in neurons. The levels of some cytokines such as TNF-α, IL-1β in the striatum of PD rat models increased compared to those of normal rats. The results of the therapeutics experiments show that notoginsenoside-Rg1 may repress the immune inflammation response and regulate the immune function through the neuro-immune molecular network. Therefore, notoginsenoside-Rg1 can be used as an effective drug for anti-oxidation and anti-inflammation, and can be used in the therapy of Parkinson＇s disease（PD）.展开更多
Using the Three Rivers Headwaters Area in China as a pilot project, this study has investigated the effectiveness of the ecological compensation policies and practices have implemented in this area over the past decad...Using the Three Rivers Headwaters Area in China as a pilot project, this study has investigated the effectiveness of the ecological compensation policies and practices have implemented in this area over the past decade. Major issues have encountered during the implementation process, including the formidable extent of grassland degradation, the comprehensive nature of measures needed to restore the ecosystem, and the time needed to achieve these goals. These issues are discussed, and remedial measures proposed. They include: drafting regulations giving the Three Rivers Headwaters Area ecological protection, setting aside funds for ecological compensation and establishing a national park, using an ecological assets accounting methodology for financial reporting purposes, designing a science-based approach for conducting the livestock husbandry population migration, enhancing the oversight capacity for all aspects of the ecological compensation process, and making an overall plan to promote the harmonious development of this area together with other regions in Qinghai Province.展开更多
文摘After establishing hemi-Parkinsonian rat models, the relationships between neuron death and the expression of several proteins, such as c-Fos, GFAP, GDNF, NF-κB and some cytokines were determined. Therapeutics experiments with notoginsenoside-Rg1 were carried out. The research results show that the expressions of GFAP, NF-Kκ and c-Fos will obviously increase in the lesion side of the striatum and the expression of GDNF will decrease, which implies that the signal transduction pathway may participate in the apoptosis in neurons. The levels of some cytokines such as TNF-α, IL-1β in the striatum of PD rat models increased compared to those of normal rats. The results of the therapeutics experiments show that notoginsenoside-Rg1 may repress the immune inflammation response and regulate the immune function through the neuro-immune molecular network. Therefore, notoginsenoside-Rg1 can be used as an effective drug for anti-oxidation and anti-inflammation, and can be used in the therapy of Parkinson＇s disease（PD）.
基金supported by the Natural Science Foundation of China (Grant No. 41301632Key Consulting Foundation of the Chinese Academy of Engineering (Grant No.2012-XZl 13)
文摘Using the Three Rivers Headwaters Area in China as a pilot project, this study has investigated the effectiveness of the ecological compensation policies and practices have implemented in this area over the past decade. Major issues have encountered during the implementation process, including the formidable extent of grassland degradation, the comprehensive nature of measures needed to restore the ecosystem, and the time needed to achieve these goals. These issues are discussed, and remedial measures proposed. They include: drafting regulations giving the Three Rivers Headwaters Area ecological protection, setting aside funds for ecological compensation and establishing a national park, using an ecological assets accounting methodology for financial reporting purposes, designing a science-based approach for conducting the livestock husbandry population migration, enhancing the oversight capacity for all aspects of the ecological compensation process, and making an overall plan to promote the harmonious development of this area together with other regions in Qinghai Province.
