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Galectin-9在HBV感染患者中表达的应用价值
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作者 张洛铭 韩国庆 +1 位作者 郭伟利 王春艳 《医学检验与临床》 2017年第6期17-20,共4页
目的:探讨半乳糖凝集素-9(Galectin-9)在乙型肝炎病毒(HBV)感染患者中表达及临床应用价值.方法:2014年6月~2016年5月选取监测点收治的84例HBV感染患者为研究对象,其中慢性乙型肝炎22例,急性乙型肝炎24例,乙型肝炎肝硬化20例,肝... 目的:探讨半乳糖凝集素-9(Galectin-9)在乙型肝炎病毒(HBV)感染患者中表达及临床应用价值.方法:2014年6月~2016年5月选取监测点收治的84例HBV感染患者为研究对象,其中慢性乙型肝炎22例,急性乙型肝炎24例,乙型肝炎肝硬化20例,肝细胞癌18例,另选取80例健康体检者为对照组.采用酶联免疫法测定各组血清Galectin-9、 白细胞介素-4,10(IL-4,10)、 干扰素γ(INF-γ)水平,同时采用全自动化生化分析仪测定各组血清丙氨酸氨基转移酶(ALT)、 门冬氨酸氨基转移酶(AST)、 总胆红素(TBil)、 实时荧光PCR定量法HBV-DNA水平,采用ROC曲线分析Galectin-9在HBV感染中的应用价值.结果:HBV感染组血清Galectin-9、IL-4、IL-10、INF-γ、ALT、AST、Tbil及HBV-DNA水平显著高于对照组(P〈0.05).肝硬化、 肝细胞癌患者Galectin-9、IL-4、IL-10、INF-γ、ALT、AST、TBil及HBV-DNA水平高于急、 慢性乙型肝炎(P〈0.05).经Pearson相关因素分析可知,Galectin-9与IL-4、IL-10、INF-γ、HBV-DNA呈正相关(P〈0.05),而与ALT、AST、TBil无相关性(P〉0.05).HBV-DNA与IL-4、IL-10、INF-γ、ALT、AST、Tbil呈正相关(P〈0.05).根据ROC曲线可知,Galectin-9曲线下面积、 阳性预测值、 阴性预测值、 灵敏性、 特异性均高于IL-4、IL-10、INF-γ、ALT、AST、Tbil.结论:Galectin-9在HBV感染的肝硬化及肝细胞癌患者中的表达水平较高,与IL-4、IL-10、INF-γ、HBV-DNA呈显著相关性.Galectin-9在HBV感染患者病情诊断中具有较高的灵敏性及特异性,通过测定其水平对预测患者病情进展及预后具有一定的意义. 展开更多
关键词 半乳糖凝集素-9 乙型肝炎病毒 乙型肝炎 肝硬化 肝细胞癌
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Electro-acupuncture Treatment for Internet Addiction: Evidence of Normalization of Impulse Control Disorder in Adolescents 被引量:11
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作者 YANG Yang LI Hui +3 位作者 CHEN Xi-xi zhang luo-ming HUANG Bing-jie ZHU Tian-min 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2017年第11期837-844,共8页
Objective: To observe the impacts of electro-acupuncture(EA) and psychological intervention(PI) on impulsive behavior among internet addiction(IA) adolescents. Methods: Thirty-two IA adolescents were allocated... Objective: To observe the impacts of electro-acupuncture(EA) and psychological intervention(PI) on impulsive behavior among internet addiction(IA) adolescents. Methods: Thirty-two IA adolescents were allocated to either EA(16 cases) or PI(16 cases) group by a randomized digital table. Subjects in the EA group received EA treatment and subjects in the PI group received cognition and behavior therapy. All adolescents underwent 45-d intervention. Sixteen healthy volunteers were recruited into a control group. Barratt Impulsiveness Scale(BIS-11) scores, Young's Internet Addiction Test(IAT) as well as the ratio of brain N-acetyl aspartate(NAA) to creatine(NAA/Cr) and choline(Cho) to creatine(Cho/Cr) were recorded by magnetic resonance spectroscopy before and after intervention respectively. Results: The IAT scores and BIS-11 total scores in both EA and PI group were remarkably decreased after treatment(P〈0.05), while EA group showed more significant decrease in certain BIS-11 sub-factors(P〈0.05). Both NAA/Cr and Cho/Cr were significantly improved in EA group after treatment(P〈0.05); however, there were no significant changes of NAA/Cr or Cho/Cr in PI group after treatment(P〉0.05). Conclusions: Both EA and PI had significantly positive effect on IA adolescents, especially in the aspects of psychological experiences and behavioral expressions, EA might have an advantage over PI in terms of impulsivity control and brain neuron protection. The mechanism underlying this advantage might be related to the increased NAA and Cho levels in prefrontal and anterior cingulate cortices. 展开更多
关键词 internet addiction electro-acupuncture Barratt Impulsiveness Scale magnetic resonance spectroscopy impulse behavior
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