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可视化引导小鼠子宫灌注方法的建立
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作者 张少通 李维 +3 位作者 王贵波 柳少光 辛蕊华 仇正英 《中兽医医药杂志》 CAS 2023年第2期11-14,共4页
为了减少因盲插而造成子宫的机械损伤和穿孔,提高小鼠子宫灌注的准确率与成功率,连续5 d对雌性小鼠阴道上皮细胞进行H.E染色,确定发情周期,通过具有照明与摄像的仪器辅助引导子宫插管,评估各时期子宫颈口紧张度及子宫插管难度,然后在第... 为了减少因盲插而造成子宫的机械损伤和穿孔,提高小鼠子宫灌注的准确率与成功率,连续5 d对雌性小鼠阴道上皮细胞进行H.E染色,确定发情周期,通过具有照明与摄像的仪器辅助引导子宫插管,评估各时期子宫颈口紧张度及子宫插管难度,然后在第5天筛选出子宫插管评价为困难的小鼠,通过可视化引导对其子宫灌注染液,最后处死小鼠,解剖小鼠腹腔,检查子宫染色情况。结果显示,发情期小鼠子宫颈口紧张比例低于其他情期小鼠(P<0.05),发情间期小鼠子宫插管困难比例高于其他情期小鼠(P<0.05);对第5天进行子宫灌注染液的小鼠解剖,显示子宫染色全部成功。可视化引导子宫灌注提供了可靠易行的子宫灌注方法,可减少因盲插或开腹方法所引入的人为因素及误差。 展开更多
关键词 子宫灌注 可视化引导子宫插管 发情周期
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炎症在衰老与衰老相关疾病中的作用 及机制研究进展 被引量:1
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作者 白可 张少童 +2 位作者 詹蔷 陈陟阳 鞠振宇 《生物医学转化》 2023年第2期13-21,共9页
中国人口老龄化问题日趋严峻。延缓组织器官衰老,预防和治疗衰老相关的疾病,制定干预和延缓衰老的安全有效策略已成为亟待解决的重要科学问题。慢性炎症累积促进细胞及机体衰老,是多组织器官衰老的共性特征之一。本文综述了炎症在衰老... 中国人口老龄化问题日趋严峻。延缓组织器官衰老,预防和治疗衰老相关的疾病,制定干预和延缓衰老的安全有效策略已成为亟待解决的重要科学问题。慢性炎症累积促进细胞及机体衰老,是多组织器官衰老的共性特征之一。本文综述了炎症在衰老及衰老相关疾病中的作用及调控机制,以及靶向干预炎症信号延缓衰老的最新研究进展。 展开更多
关键词 衰老 炎症 衰老相关疾病 炎症信号靶向干预
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盐度影响沉积物抗侵蚀性的环形水槽试验研究 被引量:2
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作者 代馨楠 贾永刚 +3 位作者 张少同 张淑玉 张皓清 单红仙 《海洋地质与第四纪地质》 CAS CSCD 北大核心 2020年第3期222-230,共9页
黄河口海域盐度变化受入海径流量、海洋动力条件及气候等影响,时空变化显著。河口区盐度场的变化不仅会影响营养盐、污染物的运输,还会改变入海泥沙的沉降及固结特性,进一步影响沉积物的抗侵蚀性。为研究不同盐度环境对沉积物抗侵蚀性... 黄河口海域盐度变化受入海径流量、海洋动力条件及气候等影响,时空变化显著。河口区盐度场的变化不仅会影响营养盐、污染物的运输,还会改变入海泥沙的沉降及固结特性,进一步影响沉积物的抗侵蚀性。为研究不同盐度环境对沉积物抗侵蚀性的影响,选用黄河三角洲沉积物进行室内循环水槽试验,模拟不同盐度条件下沉积物发生侵蚀再悬浮的过程。研究得出在本研究区盐度0~36‰范围内,黄河口细颗粒沉积物临界切应力值存在明显差异,变化范围为0.055 6~0.080 6 Pa。固结程度相同,沉积物临界切应力随盐度的增加呈对数增长特征,在盐度小于9‰的条件下,黄河口细颗粒沉积物抗侵蚀性受盐度环境变化的影响尤为明显;固结程度不同,随着固结时间的推移,盐度环境的增加对沉积物临界切应力的促进作用减小。 展开更多
关键词 盐度 细粒沉积物 侵蚀 临界切应力
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Vertical Migration of Fine-Grained Sediments from Interior to Surface of Seabed Driven by Seepage Flows–‘Sub-Bottom Sediment Pump Action' 被引量:8
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作者 zhang shaotong JIA Yonggang +5 位作者 WEN Mingzheng WANG Zhenhao zhang Yaqi ZHU Chaoqi Li Bowen LIU Xiaolei 《Journal of Ocean University of China》 SCIE CAS CSCD 2017年第1期15-24,共10页
A scientific hypothesis is proposed and preliminarily verified in this paper: under the driving of seepage flows, there might be a vertical migration of fine-grained soil particles from interior to surface of seabed, ... A scientific hypothesis is proposed and preliminarily verified in this paper: under the driving of seepage flows, there might be a vertical migration of fine-grained soil particles from interior to surface of seabed, which is defined as ‘sub-bottom sediment pump action' in this paper. Field experiments were performed twice on the intertidal flat of the Yellow River delta to study this process via both trapping the pumped materials and recording the pore pressures in the substrate. Experimental results are quite interesting as we did observe yellow slurry which is mainly composed of fine-grained soil particles appearing on the seabed surface; seepage gradients were also detected in the intertidal flat, under the action of tides and small wind waves. Preliminary conclusions are that ‘sediment pump' occurs when seepage force exceeds a certain threshold: firstly, it is big enough to disconnect the soil particles from the soil skeleton; secondly, the degree of seabed fluidization or bioturbation is big enough to provide preferred paths for the detached materials to migrate upwards. Then they would be firstly pumped from interior to the surface of seabed and then easily re-suspended into overlying water column. Influential factors of ‘sediment pump' are determined as hydrodynamics(wave energy), degree of consolidation, index of bioturbation(permeability) and content of fine-grained materials(sedimentary age). This new perspective of ‘sediment pump' may provide some implications for the mechanism interpretation of several unclear geological phenomena in the Yellow River delta area. 展开更多
关键词 sediment PUMP action vertical migration FINE-GRAINED PORE pressure SEEPAGE FLOWS
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Wave flume experiments on the contribution of seabed fluidization to sediment resuspension 被引量:6
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作者 zhang shaotong JIA Yonggang +5 位作者 WANG Zhenhao WEN Mingzheng LU Fang zhang Yaqi LIU Xiaolei SHAN Hongxian 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2018年第3期80-87,共8页
Sediment resuspension is commonly assumed to be eroded from the seabed surface by an excess bottom shear stress and evolves in layers from the top down. Although considerable investigations have argued the importance ... Sediment resuspension is commonly assumed to be eroded from the seabed surface by an excess bottom shear stress and evolves in layers from the top down. Although considerable investigations have argued the importance of wave-induced seabed fluidization in affecting the sediment resuspension, few studies have been able to reliably evaluate its quantitative contribution till now. Attempt is made to preliminarily quantify the contribution of fluidization to resuspension using a series of large-scale wave flume experiments. The experimental results indicated that fluidization of the sandy silts of the Huanghe Delta account for 52.5% and 66.8% of the total resuspension under model scales of 4/20 and 6/20(i.e., relative water depth: the ratio of wave height to water depth), respectively. Some previously reported results obtained using the same flume and sediments are also summarized for a contrastive analysis, through which not only the positive correlation is confirmed, but also a parametric equation for depicting the relationship between the contribution of fluidization and the model scale is established. Finally, the contribution of fluidization is attributed to two physical mechanisms:(1) an attenuation of the erosion resistance of fluidized sediments in surface layers due to the disappearing of original cohesion and the uplifting effect resulting from upward seepage flows, and(2) seepage pumping of fines from the interior to the surface of fluidized seabed. 展开更多
关键词 EROSION shear stress seepage flows pore pressure build up fine-grained particles Huanghe Delta
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铁细菌对供水系统金属管材腐蚀行为的影响
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作者 张少通 李伟英 +4 位作者 徐心远 李悦 梁莉 周淑云 李宪宗 《净水技术》 CAS 2022年第9期59-66,173,共9页
铁细菌(iron bacteria,IB)是供水系统中影响金属管材腐蚀的主要微生物。从实际运行供水管道中提取IB,选用304不锈钢、316不锈钢、Q235碳钢和球墨铸铁,采用电化学分析、表面分析等方法,研究IB对上述管材腐蚀行为的影响。结果表明,IB体系... 铁细菌(iron bacteria,IB)是供水系统中影响金属管材腐蚀的主要微生物。从实际运行供水管道中提取IB,选用304不锈钢、316不锈钢、Q235碳钢和球墨铸铁,采用电化学分析、表面分析等方法,研究IB对上述管材腐蚀行为的影响。结果表明,IB体系中304不锈钢、316不锈钢的腐蚀速率在试验周期内随时间增加逐渐增大,Q235碳钢、球墨铸铁腐蚀速率则先快速增大后逐渐减小。IB体系中304不锈钢、316不锈钢表面产生较薄腐蚀层,球墨铸铁表面存在大量腐蚀产物和IB,Q235碳钢表面发现少量产物。球墨铸铁和Q235碳钢的腐蚀产物主要为磁铁矿、针铁矿、镁铁氧化物,但这些腐蚀产物在304不锈钢、316不锈钢表面未检出。IB对4种管材的腐蚀作用排序为:球墨铸铁>Q235碳钢>304不锈钢>316不锈钢。 展开更多
关键词 铁细菌 供水系统 金属管材 电化学分析 腐蚀速率
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Experimental Researches on the Accuracy of Micro- Electromechanical Accelerometer-Array in Seafloor Failure Deformation Measurement
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作者 WANG Zhenhao LIU Xiaolei +3 位作者 zhang shaotong WEN Mingzheng SHAN Hongxian JIA Yonggang 《Journal of Ocean University of China》 SCIE CAS CSCD 2022年第5期1198-1204,共7页
At present,there are few technologies applied to in situ observation of seabed deformation,among which the micro-electromechanical accelerometer-array(hereinafter referred to as accelerometers array)is a very advantag... At present,there are few technologies applied to in situ observation of seabed deformation,among which the micro-electromechanical accelerometer-array(hereinafter referred to as accelerometers array)is a very advantageous measurement method,with both commercial products and successful application cases.However,the coupling effect between accelerometer-array and sur-rounding soil and the linkage effect of accelerometer-array itself during the deformation may influence the accuracy and reliability of the measurement data.A simulation test chamber was designed and processed,and four groups of simulation tests were carried out to explore the coupling effect and linkage effect of accelerometer-array in the soil with different degree of consolidation.The results show that the accelerometer-array and the soil coupled well,and the coupling effect is positively correlated with the degree of soil consoli-dation.The ratio of accumulative deviation to soil lateral deformation is high at the initial stage of deformation(0-50 mm)and reduced with the continuous increase of deformation(>100 mm).In the process of liquefied soil deformation,the linkage effect of accelerometer array can be ignored,and is negatively correlated with the degree of soil consolidation.A concept to improve the measurement accu-racy of accelerometer-array in different seafloor failure deformation modes is proposed.The research results provide references for the modification of accelerometer-array and the improvement for other flexible rod-shaped deformation sensors. 展开更多
关键词 micro-electromechanical accelerometer-array seafloor failure deformation in situ observation coupling effect linkage effect
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内孤立波悬浮海底沉积物研究进展 被引量:4
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作者 田壮才 郭秀军 +3 位作者 余乐 贾永刚 张少同 乔路正 《地球科学进展》 CAS CSCD 北大核心 2018年第2期166-178,共13页
内孤立波是存在于层结海洋内部的非线性、大振幅波动,其强劲的垂向和水平运动以及破碎导致的涡旋和湍流作用,对海洋环境、海底沉积物和海洋工程产生重要的影响。围绕内孤立波作用下沉积物再悬浮的发生过程,对前人开展的大量研究工作及... 内孤立波是存在于层结海洋内部的非线性、大振幅波动,其强劲的垂向和水平运动以及破碎导致的涡旋和湍流作用,对海洋环境、海底沉积物和海洋工程产生重要的影响。围绕内孤立波作用下沉积物再悬浮的发生过程,对前人开展的大量研究工作及取得的研究成果进行了系统分析与总结,从内孤立波向岸传播的破碎机制、悬浮沉积物模式以及引起的海床动力响应进行评述,并分析内孤立波悬浮沉积物判定理论和对海底的作用,对目前研究工作中尚未解决的问题进行总结。该工作对于系统深入认识内孤立波引起的海底沉积物再悬浮发生过程,以及对海底底形的改造能力具有重要价值,为进一步研究内孤立波对海洋生态环境动力过程及深海沉积过程提供借鉴。 展开更多
关键词 内孤立波 破碎机制 沉积物 动力响应 再悬浮
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浅析联合国发展融资机制改革创新及对中国参与国际多边发展援助的影响 被引量:2
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作者 万泰雷 张绍桐 《国际经济评论》 CSSCI 北大核心 2019年第1期77-88,181,共13页
联合国可持续发展目标的提出,为包括联合国在内的全球发展系统提出了巨大的资金需求。然而在当前形势下,全球发展融资存在巨大的资金缺口;全球发展融资趋势发生变化,由双边官方援助一家独大向多边援助、南南合作以及私营企业、慈善资金... 联合国可持续发展目标的提出,为包括联合国在内的全球发展系统提出了巨大的资金需求。然而在当前形势下,全球发展融资存在巨大的资金缺口;全球发展融资趋势发生变化,由双边官方援助一家独大向多边援助、南南合作以及私营企业、慈善资金参与并重的趋势发生转变。为应对国际发展融资新趋势、新挑战,联合国发展系统积极开展改革,调整战略、财务职能分配,加强资源协调整合。本文梳理了联合国发展改革的重要目标和措施,分析联合国系统及国际社会通过加强合作机制,建立国际融资机制,设计创新融资工具,推动新型债务减免和鼓励社会责任投资等创新尝试。随着联合国发展系统改革的深化,中国可对相关机遇与问题开展深入研究,顺势提升中国援助的国际影响力,兼顾受援方经济增长与社会、教育和民生发展,积极扩展新的援助合作渠道,利用多边平台在发展中国家减债中发挥积极作用,审慎应对改革过程中的问题,增强发展援助的风险防范能力。 展开更多
关键词 可持续发展目标 发展援助 联合国改革 混合融资 债务减免
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生命因您而动听——怀念片冰心教授 被引量:1
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作者 章绍同 《人民音乐》 北大核心 2020年第10期57-61,共5页
一一提起片冰心教授(1923—2019)的名字,人们自然地就会想到唐代诗人王昌龄著名的七绝《芙蓉楼送辛渐》里传颂的千古佳句:"一片冰心在玉壶",片教授的姓名就在诗句中。她的父亲片冈先生是日本医生,20世纪初渡海到福建的东山岛... 一一提起片冰心教授(1923—2019)的名字,人们自然地就会想到唐代诗人王昌龄著名的七绝《芙蓉楼送辛渐》里传颂的千古佳句:"一片冰心在玉壶",片教授的姓名就在诗句中。她的父亲片冈先生是日本医生,20世纪初渡海到福建的东山岛行医,她的母亲是东山本地人,小时候父母都叫她"阿蕉"到了读小学的时候。 展开更多
关键词 王昌龄 《芙蓉楼送辛渐》 东山岛 冰心 唐代诗人 玉壶 七绝
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