Hypotrichs are one of the highly differentiated ciliated lineages which play important roles in ecological, environmental,evolutionary and basic biological studies. In the present study, we investigated the living cha...Hypotrichs are one of the highly differentiated ciliated lineages which play important roles in ecological, environmental,evolutionary and basic biological studies. In the present study, we investigated the living characteristics, infraciliature, nuclear apparatus, ontogenesis and phylogenetic position of a marine hypotrichous ciliate, Apokeronopsis wrighti Long et al., 2008, which was isolated from coastal waters in Shenzhen, China. The new isolate resembles the type population in terms of morphological characteristics, morphometrics, and SSU rRNA gene sequence that is with a 99.7% similarity. Ontogenesis of A. wrighti is characterized by oral primordium for the proter as well as marginal and dorsal kineties anlagen in both filial products formed de novo, and the cirral row arranged along the paroral and endoral arises from several anterior frontoventral-transverse cirral streaks. Phylogenetic analyses based on SSU and concatenated gene data suggest that five species of Apokeronopsis form a monophyletic clade, and the genus Apokeronopsis is closely related to Thigmokeronopsis and Metaurostylopsis.展开更多
为探究血浆热休克蛋白90α(Heat shock protein 90α,HSP90α)水平在弥漫大B细胞淋巴瘤患者中的临床价值,了解其是否可作为弥漫大B细胞淋巴瘤患者病情监测和近期疗效判断的肿瘤指标。本研究纳入60例弥漫大B细胞淋巴瘤患者。通过酶联免...为探究血浆热休克蛋白90α(Heat shock protein 90α,HSP90α)水平在弥漫大B细胞淋巴瘤患者中的临床价值,了解其是否可作为弥漫大B细胞淋巴瘤患者病情监测和近期疗效判断的肿瘤指标。本研究纳入60例弥漫大B细胞淋巴瘤患者。通过酶联免疫吸附试验检测血浆HSP90α表达,了解其与患者临床病理特征的关系以及治疗前后该指标的变化情况。结果发现弥漫大B细胞淋巴瘤患者血浆HSP90α中位数为86.57 ng/ml。HSP90α的水平与Lugano分期、IPI评分、外周血LDH水平、ECOG评分以及结外病变个数存在统计学关联。同一患者中HSP90α和LDH水平之间呈显著正相关。在获得肿瘤客观缓解或疾病控制的患者中,评估疗效时HSP90α水平较基线显著下降。而在一线治疗失败时,患者血浆HSP90α水平较基线显著升高。提示HSP90α可作为弥漫大B细胞淋巴瘤患者病情监测及近期疗效判断的血浆肿瘤指标。展开更多
基金supported by the Natural Science Foundation of Shaanxi Province(Nos.2023-JC-QN-0214,2023JC-QN-0185)the Postdoctoral Science Foundation of Shaanxi Province(No.2023BSHEDZZ199)the Fundamental Research Funds for the Central Universities(No.GK202207019)。
文摘Hypotrichs are one of the highly differentiated ciliated lineages which play important roles in ecological, environmental,evolutionary and basic biological studies. In the present study, we investigated the living characteristics, infraciliature, nuclear apparatus, ontogenesis and phylogenetic position of a marine hypotrichous ciliate, Apokeronopsis wrighti Long et al., 2008, which was isolated from coastal waters in Shenzhen, China. The new isolate resembles the type population in terms of morphological characteristics, morphometrics, and SSU rRNA gene sequence that is with a 99.7% similarity. Ontogenesis of A. wrighti is characterized by oral primordium for the proter as well as marginal and dorsal kineties anlagen in both filial products formed de novo, and the cirral row arranged along the paroral and endoral arises from several anterior frontoventral-transverse cirral streaks. Phylogenetic analyses based on SSU and concatenated gene data suggest that five species of Apokeronopsis form a monophyletic clade, and the genus Apokeronopsis is closely related to Thigmokeronopsis and Metaurostylopsis.
文摘为探究血浆热休克蛋白90α(Heat shock protein 90α,HSP90α)水平在弥漫大B细胞淋巴瘤患者中的临床价值,了解其是否可作为弥漫大B细胞淋巴瘤患者病情监测和近期疗效判断的肿瘤指标。本研究纳入60例弥漫大B细胞淋巴瘤患者。通过酶联免疫吸附试验检测血浆HSP90α表达,了解其与患者临床病理特征的关系以及治疗前后该指标的变化情况。结果发现弥漫大B细胞淋巴瘤患者血浆HSP90α中位数为86.57 ng/ml。HSP90α的水平与Lugano分期、IPI评分、外周血LDH水平、ECOG评分以及结外病变个数存在统计学关联。同一患者中HSP90α和LDH水平之间呈显著正相关。在获得肿瘤客观缓解或疾病控制的患者中,评估疗效时HSP90α水平较基线显著下降。而在一线治疗失败时,患者血浆HSP90α水平较基线显著升高。提示HSP90α可作为弥漫大B细胞淋巴瘤患者病情监测及近期疗效判断的血浆肿瘤指标。
