便利性视角下青岛市旅游景区与配套设施空间匹配关系研究

协调城市旅游景区与配套设施的空间结构关系,有助于提高城市旅游便利性,促进旅游业高质量发展。本研究基于高德地图等多源数据平台,获取青岛市A级旅游景区和配套设施的POI数据,运用核密度分析、波段统计分析、缓冲区分析等空间分析技术以及不一致指数等数理统计方法,识别和揭示青岛市旅游景区和配套设施空间分布格局,并在便利性视角下对二者的空间匹配关系进行比较分析。研究结果表明:(1)青岛市旅游景区与配套设施空间分布不均,核心聚集区存在一定的地域耦合性。配套服务设施对旅游景区便利性的影响权重排序为:餐饮高于交通,高于住宿,高于购物。(2)除青岛市莱西和崂山区外,其余城区旅游景区与配套设施的数量匹配关系较好,旅游便利化程度较高。(3)各旅游景区与配套设施距离匹配关系差异明显,部分景区交通便利性高但食宿便利性低,近九成旅游景区近邻区域存在配套设施盲点。(4)在便利性视角下,胶州湾西北沿岸旅游景区与配套设施空间匹配关系较协调,其余城区协调匹配关系有待提升。

新技术应用对住院费用的影响研究——基于DRG工具

目的分析某医院国家重点学科新技术应用对部分DRG病组住院费用的影响。方法 2018年12月—2019年3月病案首页数据和北京市按疾病诊断相关分组收付费模拟运行数据,采用Mann-Whitney U检验和Spearman线性相关分析等方法,比较CB19、CB39、DD29的3个DRG病组新技术应用对住院费用及构成的影响。结果应用新技术组总费用高于未应用组(P<0.05),应用新技术对不同DRG组医疗费用构成的影响不同,应用新技术是造成3个病组亏损的主要原因。结论新技术的应用会使住院费用升高,造成DRG结算病例亏损。为鼓励技术创新和医学进步,应在卫生技术评估基础上完善DRG支付标准。

腹腔镜子宫下段肌层折叠缝合联合宫腔镜治疗剖宫产术后子宫瘢痕憩室的临床效果观察

目的观察腹腔镜子宫下段肌层折叠缝合联合宫腔镜治疗剖宫产术后子宫瘢痕憩室(CSD)的临床效果。方法选择2015年1月至2019年12月邯郸市中心医院收治的CSD患者26例,根据治疗方式不同分为观察组(采用宫腔镜子宫瘢痕憩室切除联合腹腔镜子宫下段肌层折叠缝合修复子宫下段肌层,14例)和对照组(采用宫腔镜引导下经腹腔镜切除子宫瘢痕后重新缝合修复子宫下段肌层,12例)。比较两组患者的手术时间、术中出血量、术后住院时间,以及术后子宫下段肌层的恢复情况。结果两组手术时间、术后住院时间比较差异无统计学意义(P>0.05)。观察组术中出血量少于对照组,差异有统计学意义(P<0.01)。与术前比较,两组术后子宫下段肌层厚度均显著增厚(P<0.01),但两组间比较差异无统计学意义(P>0.05)。结论腹腔镜子宫下段肌层折叠缝合联合宫腔镜治疗CSD疗效确切,且手术操作更简易,术中出血量更少,值得临床推广。

Spatial patterns of interprovincial mountain geographical names in China and implications for regional governance

Suffering from fragile environment, poor accessibility and infrastructure, as well as social,political and economic marginality, the interprovincial mountain geographical entities are difficult areas for the regional governance in China.By analyzing the spatial patterns and the influencing factors of the interprovincial mountain geographical names(IMGNs), the goal of this research is to clarify the geographical features of IMGNs and offer alternatives for the management of interprovincial mountain regions in China. The spatial visualization,the analysis of spatial agglomeration and the influencing factors of IMGNs were all implemented under a geographical information system. Results showed that there were 6869 IMGNs in China according to the database of "China's Second National Survey of Geographical Names(2014-2018)",including 4209 mountain geographical names, 1684 mountain peak geographical names and 976 the other mountain geographical names. Hunan Province had the largest number of names while Shanghai had the smallest number of names. In addition, the spatial variance of the mountain peak names and the mountain names were larger than that of the other mountain geographical names, and the IMGNs showed a significant clustering phenomenon in the southern part of China. The relative elevation and the population had an impact on the distribution of the IMGNs. The largest number of the names occurred where the relative elevation was between 1000-2000 m and where the population was between 40-50 million. Density of unnamed interprovincial mountain geographical entities declined from west to east in China. The analysis of generic names of different types of IMGNs implied that the naming of IMGNs is inconsistent. Based on these analyses, it is suggested that the government should take the IMGNs as management units, strengthen the naming of unnamed interprovincial mountain geographical entities, standardize the generic names of IMGNs and identify areas of poverty based on the survey of IMGNs.

Restriction Fragment Length Polymorphism in the MC4R Gene and Its Genetic Effects on Carcass and Feather-down Traits in Geese

Carcass,meat quality,and feather-down traits of 123 geese from an F_1 population of Wanxi White goose(male parent)and Sichuan White goose(female parent)were measured,and an additional 12 compound indices were constructed from the single traits,using factor analysis.The coding region of melanocortin receptor-4(MC4R)gene was amplified by PCR and the products were digested with four restriction endonucleases Hinf I,Ear I,Pst I,and Pvu II to detect restriction fragment length polymorphism(RFLP)in the MC4R gene,to analyze its associations with the traits.The only RFLP was exposed by digesting with Hinf I indicating two genotypes,HH and Hh,with frequencies of allele H and h being 0.8902 and 0.1098 in the F_1 population.Significant effects of genotype HH were found on carcass weight,eviscerated weight(with giblet),liver weight,heart weight,stomach percentage,abdominal fat percentage,breast muscle drip water loss and down proportion and many of the compound indices,and all genotypic contribution percentages(CP,genotypic effect on the population mean)were between-5%and 5%;effects of genotype Hh with the MC4R gene mutation,were not significant.Effects of genotype Hh were significant on two of the compound indices related to fat deposition:the fat index(CP=3.314%,P<0.05)and fatty acid quality(CP=1.218%,P<0.05).

新型美白剂4-(3,5-二甲氧基苯乙基)-1,3-苯二酚的合成及其性能

以2,4-二羟基苯甲醛、3,5-二甲氧基溴苄为原料,经过苄基化反应、Arbuzov反应、Wittig-Horner反应、催化加氢等过程合成了新型美白剂4-(3,5-二甲氧基苯乙基)-1,3-苯二酚,并通过1H-NMR、13C-NMR与IR确定其化学结构,应用DPPH自由基清除实验、酪氨酸酶活性抑制实验评价其生物活性。结果表明:DPPH自由基半清除浓度IC50=0.011 mmol/L,明显低于苯乙基间苯二酚(IC50=0.084 mmol/L)、α-熊果苷(IC50=0.195 mmol/L)和光甘草定(IC50=0.385 mmol/L);以L-酪氨酸为底物时,对酪氨酸酶单酚酶的半抑制浓度IC50=0.00137 mmol/L明显低于苯乙基间苯二酚(IC50=0.00582 mmol/L)、α-熊果苷(IC50=3.94 mmol/L)和光甘草定(IC50=0.0051 mmol/L);以L-多巴为底物时,对酪氨酸酶二酚酶的半抑制浓度IC50=0.0322 mmol/L,低于苯乙基间苯二酚(IC50=0.0575 mmol/L),但高于光甘草定(IC50=0.0076 mmol/L),α-熊果苷对酪氨酸酶二酚酶的半抑制浓度为负值,表现为激活作用。两组数据表明新型美白剂4-(3,5-二甲氧基苯乙基)-1,3-苯二酚对酪氨酸酶具有较高的抑制活性。

萘酰亚胺类荧光探针的研究进展

萘酰亚胺具有刚性平面结构和大π键共轭体系,可以作为很好的发色团,而且4号位点具有较高的化学活性,很容易和其他化合物反应,为该类荧光探针分子的多样化提供了保障。如今萘酰亚胺在荧光探针方向的发展越来越成熟,其在环境污染检测以及医疗上疾病的检测和预防方面都具有灵敏度高、选择性好的特点,因此,受到科技工作者的青睐。近年来,越来越多的具有不同用途的荧光探针分子被合成出来。本文对近年来不同种类的萘酰亚胺类荧光探针分子进行了总结和分类。

荧光检测人羧酸酯酶的研究进展

羧酸酯酶是丝氨酸酯酶大家族的一员,它们主要是对脂类物质起水解作用,其活性直接与许多的疾病相关,人体中主要存在人羧酸酯酶1和人羧酸酯酶2。因此,在检测酶活性方面受到了广大研究者的青睐。传统的检测方法过程繁琐,费时费力,设备昂贵,检测不出酶的活性。近年来荧光探针技术成为测量生物样本中人羧酸酯酶1、人羧酸酯酶2真实活性的实用、敏感、高选择性、高精确度的检测方法。本文主要针对近年来用于检测酶活性的荧光探针进行总结。

盐排泄依赖的肾脏病高血压治疗进展

高血压患者逐年增多,而多达1/2的高血压人群存在盐敏感性。本综述分析近年来通过盐排泄依赖的肾病高血压的相关研究,探寻盐排泄和高血压之间的关联,以期为临床治疗高血压探索新的思路和方法。利用万方数据、PubMed中英文数据库,中文以“高血压”“钠”和“肾”为关键词,检索2015-01-2019-05相关文献,共检索出合格文献21篇,剔除文献18篇,纳入文献3篇;英文以“Sodium excretion”“hypertension”“chronic kidney disease”为关键词,检索2015-01-2019-05相关文献,相关文献101篇。纳入标准:符合检索内容的临床研究、文献、著作。剔除标准:(1)综述类文献;(2)研究资料缺失或质量较差。最终纳入文献59篇。结果表明,终末期肾病中容量负荷增加为常见的加重高血压的因素,与盐摄入量增高有关。因此,肾脏病高血压患者中排盐相关性降压治疗十分重要。目前排盐治疗主要是通过增加肾脏和肠道盐排泄为主,为临床治疗高血压病提供了重要思路。

便携式水蒸气发生器的设计及教学应用

改进了传统水蒸气发生装置,通过半加工,将加热装置和蓄水装置通过合理设计整合在一起。与传统蒸馏实验当中使用的水蒸气发生器相比,此装置在实验教学中具有安装简单、节约能源、提高效率、安全可靠等优点。