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Investigation of nitroxoline-human serum albumin interactions by spectroscopic methods 被引量:1
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作者 zhang wan ju XIONG Xu Jie +4 位作者 wanG Fang LI Li zhang Yan XIAO Wen Ping LIU Yi 《Science China Chemistry》 SCIE EI CAS 2014年第12期1690-1695,共6页
Nitroxoline is a wide spectrum antibacterial and is one of the most important urinary antiseptics.The interaction between nitroxoline and human serum albumin(HSA)has been investigated systematically by fluorescence sp... Nitroxoline is a wide spectrum antibacterial and is one of the most important urinary antiseptics.The interaction between nitroxoline and human serum albumin(HSA)has been investigated systematically by fluorescence spectroscopy,synchronous fluorescence,three-dimensional fluorescence,CD spectroscopy and UV-Vis absorption spectroscopy.The results indicated that the quenching of HSA by nitroxoline was static.The corresponding thermodynamic parameters △H,△S and △G calculated according to van’t Hoff equation revealed that the intermolecular forces acting between nitroxoline and HSA were mainly hydrogen bonding and van der Waals forces.The conformational changes in the interaction were studied by synchronous fluorescence,CD spectroscopy and three-dimensional fluorescence spectra which showed changes in the microenvironment and conformation of HSA. 展开更多
关键词 nitroxoline human serum albumin spectroscopic methods INTERACTION
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