目的系统评价窄谱中波紫外线(narrow band ultraviolet,NB-UVB)联合甲氨蝶呤(methotrexate,MTX)治疗银屑病的疗效性和安全性。方法计算机检索PubM ed、The Cochrane Library、SpringerL ink、CNKI、VIP和WanF ang Data数据库,选择NB-UV...目的系统评价窄谱中波紫外线(narrow band ultraviolet,NB-UVB)联合甲氨蝶呤(methotrexate,MTX)治疗银屑病的疗效性和安全性。方法计算机检索PubM ed、The Cochrane Library、SpringerL ink、CNKI、VIP和WanF ang Data数据库,选择NB-UVB联合MTX治疗,与仅予NB-UVB或MTX治疗银屑病患者比较的随机临床对照试验,检索时限均为2004年1月至2017年1月。由研究者根据纳入标准独立筛选文献、提取资料并评价质量后,采用RevM an 5.3软件进行Meta分析。结果共纳入文献8篇,银屑病患者461例。Meta分析结果显示,NB-UVB联合MTX治疗组痊愈率均优于单用NB-UVB组(P<0.0001)和MTX组(P<0.0001),并且联合治疗组UVB剂量低于单用UVB治疗组(P<0.0001)。但两种治疗方案在皮肤红斑(P>0.05)和皮肤瘙痒(P>0.05)发生率比较,差异无统计学意义。结论 NB-UVB联合MTX可明显提高银屑病患者的治愈率和有效率,对银屑病患者的皮肤红斑和瘙痒等不良反应无明显疗效。但受纳入研究质量和数量的限制,上述结论尚需开展更多高质量研究加以验证。展开更多
Objectives:The wide use of antibiotics for acne is the main cause of drug-resistant Cutibacterium acnes.However,the complete genetic sequence reference of C.acnes has not yet been reported.Herein,we report the complet...Objectives:The wide use of antibiotics for acne is the main cause of drug-resistant Cutibacterium acnes.However,the complete genetic sequence reference of C.acnes has not yet been reported.Herein,we report the complete genetic sequence of Cutibacterium acnes type strain ATCC6919.Methods:Whole-genome sequencing of Cutibacterium acnes ATCC6919 was performed using both the Illumina Hiseq4000 and PacBio RSII single-molecule real-time sequencing platforms.The generated sequence reads were de novo assembled using the HGAP3 protocol of single-molecule real-time analysis v.2.3.0 software.The draft genome was annotated and further analyzed by various bioinformatics tools.Results:The total genome length of Cutibacterium acnes ATCC6919 was 2,495,001 bp(60.02%G+C content),with 2,450 coding sequences including 2,358 proteins,45 tRNAs,9 rRNAs,and 1 sRNA.The Comprehensive Antibiotic Resistance Database showed that the gene(thy A)found in ATCC6919 was associated with resistance to aminosalicylic acid.Antimicrobial susceptibility testing showed that this isolate was not sensitive to metronidazole and sulfamethoxazole,but was sensitive to all other tested antimicrobials(erythromycin,azithromycin,clarithromycin,tetracycline,minocycline,trimethoprim,levofloxacin,ceftriaxone,and doxycycline).Conclusion:This study reports the complete genome sequence of Cutibacterium acnes ATCC6919,which provides a valuable reference for comparative analysis based on the genomic characteristics and resistance gene diversity of Cutibacterium acnes.展开更多
Pyoderma gangrenosum （PG） is a rare ulcerative cutaneous condition with distinctivecharacteristics, and the aetiology is not clear yet. PG is commonly associated with inflammatory bowel disease including ulcerative ...Pyoderma gangrenosum （PG） is a rare ulcerative cutaneous condition with distinctivecharacteristics, and the aetiology is not clear yet. PG is commonly associated with inflammatory bowel disease including ulcerative colitis and Crohn＇s disease. This condition is within the spectrum of the neutrophilic dermatoses. The features of PG are not specific histopathologically. Commonly, it is characterized by the presence of marked neutrophilic infiltrates in the dermis. The treatment of PG usually requires systemic corticosteroids or other immunospressive medications, and its course is chronic and relapsing. Some cases are resistant to these treatments. On the other hand, long-term usage of those medications naturally causes serious side effects, and an alternative effective and safe therapy is required to avoid the clinical problems associated with the drugs.展开更多
Biologic drugs have been increasingly used in the treatment of psoriasis and are especially favorable for severe,recalcitrant,and special-type cases.Therefore,appropriate,effective,and safe use of biologic drugs has d...Biologic drugs have been increasingly used in the treatment of psoriasis and are especially favorable for severe,recalcitrant,and special-type cases.Therefore,appropriate,effective,and safe use of biologic drugs has drawn attention from dermatologists.For this purpose,Chinese experts majoring in psoriasis analyzed domestic and international research data,summarized current clinical experiences,investigated features of Chinese patients with psoriasis,and finally formulated the present consensus,which provides detailed guidances to clinicians in terms of the principles and methods of the application of biologics,the efficacy and safety profile,patient screening and monitoring,main adverse events and corresponding solutions,and precautions for special patient populations.展开更多
文摘目的系统评价窄谱中波紫外线(narrow band ultraviolet,NB-UVB)联合甲氨蝶呤(methotrexate,MTX)治疗银屑病的疗效性和安全性。方法计算机检索PubM ed、The Cochrane Library、SpringerL ink、CNKI、VIP和WanF ang Data数据库,选择NB-UVB联合MTX治疗,与仅予NB-UVB或MTX治疗银屑病患者比较的随机临床对照试验,检索时限均为2004年1月至2017年1月。由研究者根据纳入标准独立筛选文献、提取资料并评价质量后,采用RevM an 5.3软件进行Meta分析。结果共纳入文献8篇,银屑病患者461例。Meta分析结果显示,NB-UVB联合MTX治疗组痊愈率均优于单用NB-UVB组(P<0.0001)和MTX组(P<0.0001),并且联合治疗组UVB剂量低于单用UVB治疗组(P<0.0001)。但两种治疗方案在皮肤红斑(P>0.05)和皮肤瘙痒(P>0.05)发生率比较,差异无统计学意义。结论 NB-UVB联合MTX可明显提高银屑病患者的治愈率和有效率,对银屑病患者的皮肤红斑和瘙痒等不良反应无明显疗效。但受纳入研究质量和数量的限制,上述结论尚需开展更多高质量研究加以验证。
文摘Objectives:The wide use of antibiotics for acne is the main cause of drug-resistant Cutibacterium acnes.However,the complete genetic sequence reference of C.acnes has not yet been reported.Herein,we report the complete genetic sequence of Cutibacterium acnes type strain ATCC6919.Methods:Whole-genome sequencing of Cutibacterium acnes ATCC6919 was performed using both the Illumina Hiseq4000 and PacBio RSII single-molecule real-time sequencing platforms.The generated sequence reads were de novo assembled using the HGAP3 protocol of single-molecule real-time analysis v.2.3.0 software.The draft genome was annotated and further analyzed by various bioinformatics tools.Results:The total genome length of Cutibacterium acnes ATCC6919 was 2,495,001 bp(60.02%G+C content),with 2,450 coding sequences including 2,358 proteins,45 tRNAs,9 rRNAs,and 1 sRNA.The Comprehensive Antibiotic Resistance Database showed that the gene(thy A)found in ATCC6919 was associated with resistance to aminosalicylic acid.Antimicrobial susceptibility testing showed that this isolate was not sensitive to metronidazole and sulfamethoxazole,but was sensitive to all other tested antimicrobials(erythromycin,azithromycin,clarithromycin,tetracycline,minocycline,trimethoprim,levofloxacin,ceftriaxone,and doxycycline).Conclusion:This study reports the complete genome sequence of Cutibacterium acnes ATCC6919,which provides a valuable reference for comparative analysis based on the genomic characteristics and resistance gene diversity of Cutibacterium acnes.
文摘Pyoderma gangrenosum （PG） is a rare ulcerative cutaneous condition with distinctivecharacteristics, and the aetiology is not clear yet. PG is commonly associated with inflammatory bowel disease including ulcerative colitis and Crohn＇s disease. This condition is within the spectrum of the neutrophilic dermatoses. The features of PG are not specific histopathologically. Commonly, it is characterized by the presence of marked neutrophilic infiltrates in the dermis. The treatment of PG usually requires systemic corticosteroids or other immunospressive medications, and its course is chronic and relapsing. Some cases are resistant to these treatments. On the other hand, long-term usage of those medications naturally causes serious side effects, and an alternative effective and safe therapy is required to avoid the clinical problems associated with the drugs.
文摘Biologic drugs have been increasingly used in the treatment of psoriasis and are especially favorable for severe,recalcitrant,and special-type cases.Therefore,appropriate,effective,and safe use of biologic drugs has drawn attention from dermatologists.For this purpose,Chinese experts majoring in psoriasis analyzed domestic and international research data,summarized current clinical experiences,investigated features of Chinese patients with psoriasis,and finally formulated the present consensus,which provides detailed guidances to clinicians in terms of the principles and methods of the application of biologics,the efficacy and safety profile,patient screening and monitoring,main adverse events and corresponding solutions,and precautions for special patient populations.
