Four new organosilane compounds containing cholesteryl group were synthesized by esterification of 3,3,5,5-tetramethyl-3,5-disila-4-oxa-cyclohexane-1-carboxylic acid and ω-hydroxyalkyl, cholesteryl carbonate in the p...Four new organosilane compounds containing cholesteryl group were synthesized by esterification of 3,3,5,5-tetramethyl-3,5-disila-4-oxa-cyclohexane-1-carboxylic acid and ω-hydroxyalkyl, cholesteryl carbonate in the presence of DCC and DMAP. Their structures were characterized by1H-NMR, IR and elemental analysis. Their phase behaviors were investigated by differential scanning calorimetry (DSC) and polarized microscopy. Results showed that these four organosilane compounds were all liquid crystalline and longer spacer was advantageous to orientation of organosilane heterocycle and cholesteryl group.展开更多
Background Myofibroblastic sarcoma was used to be a controversial neoplasm. This study investigated the clinicopathological features of 20 cases of myofibroblastic sarcoma arising in different locations. Methods The p...Background Myofibroblastic sarcoma was used to be a controversial neoplasm. This study investigated the clinicopathological features of 20 cases of myofibroblastic sarcoma arising in different locations. Methods The paraffin-embedded tissue samples from 20 cases of patients with myofibroblastic sarcoma were stained immunohistochemically, and 5 cases examined by electron microscopy. Student＇s t test was used to analyze the difference of Ki-67 labeling index between grade 1 and grade 2 myofibroblastic sarcomas. Results Histologically, the tumors were composed of slender spindle cells with eosinophilic cytoplasm, and fusiform, tapering, wavy, or plump ovoid; vesicular nuclei and a small central eosinophUic nucleoli. Immunohistochemically, the tumor cells expressed smooth muscle actin （18/20）, muscle specific actin （16/20）, fibronectin （20/20） and desmin （2/20）. Ultrastructurally, the tumor cells revealed abundant rough endoplasmic reticulum and longitudinally arranged fine filaments with focal densities in the cytoplasm. A clinical follow-up of 19 patients showed that 2 cases experienced local recurrence and distant metastasis 6 months to 4 years after the initial operation. Nine cases recurred locally 17 to 46 months after the initial excision, and 9 cases were alive with no evidence of disease. Conclusions Myofibroblastic sarcomas, which exhibit diverse histological appearance, can easily be misdiagnosed as benign tumors. Myofibroblastic sarcomas are local destructive lesions with frequent recurrence, and may metastase distantly.展开更多
文摘Four new organosilane compounds containing cholesteryl group were synthesized by esterification of 3,3,5,5-tetramethyl-3,5-disila-4-oxa-cyclohexane-1-carboxylic acid and ω-hydroxyalkyl, cholesteryl carbonate in the presence of DCC and DMAP. Their structures were characterized by1H-NMR, IR and elemental analysis. Their phase behaviors were investigated by differential scanning calorimetry (DSC) and polarized microscopy. Results showed that these four organosilane compounds were all liquid crystalline and longer spacer was advantageous to orientation of organosilane heterocycle and cholesteryl group.
基金a grant from the China Medical Board of New York(No.CMB 00-722).
文摘Background Myofibroblastic sarcoma was used to be a controversial neoplasm. This study investigated the clinicopathological features of 20 cases of myofibroblastic sarcoma arising in different locations. Methods The paraffin-embedded tissue samples from 20 cases of patients with myofibroblastic sarcoma were stained immunohistochemically, and 5 cases examined by electron microscopy. Student＇s t test was used to analyze the difference of Ki-67 labeling index between grade 1 and grade 2 myofibroblastic sarcomas. Results Histologically, the tumors were composed of slender spindle cells with eosinophilic cytoplasm, and fusiform, tapering, wavy, or plump ovoid; vesicular nuclei and a small central eosinophUic nucleoli. Immunohistochemically, the tumor cells expressed smooth muscle actin （18/20）, muscle specific actin （16/20）, fibronectin （20/20） and desmin （2/20）. Ultrastructurally, the tumor cells revealed abundant rough endoplasmic reticulum and longitudinally arranged fine filaments with focal densities in the cytoplasm. A clinical follow-up of 19 patients showed that 2 cases experienced local recurrence and distant metastasis 6 months to 4 years after the initial operation. Nine cases recurred locally 17 to 46 months after the initial excision, and 9 cases were alive with no evidence of disease. Conclusions Myofibroblastic sarcomas, which exhibit diverse histological appearance, can easily be misdiagnosed as benign tumors. Myofibroblastic sarcomas are local destructive lesions with frequent recurrence, and may metastase distantly.
