目的:对针刺联合溶栓治疗急性脑梗死(ACI)的疗效及安全性进行系统评价。方法:检索PubMed、Cochrane Library、Embase、Web of Science、中国知网、万方、维普、中国生物医学文献数据库(CBM)中关于针刺联合溶栓治疗ACI的临床随机对照试验...目的:对针刺联合溶栓治疗急性脑梗死(ACI)的疗效及安全性进行系统评价。方法:检索PubMed、Cochrane Library、Embase、Web of Science、中国知网、万方、维普、中国生物医学文献数据库(CBM)中关于针刺联合溶栓治疗ACI的临床随机对照试验,检索时间为各库建库时间至2020年3月。由2名研究者根据纳入排除标准,独立对文献进行筛选,提取评估,并使用Revman 5.3软件对数据进行Meta分析。结果:共纳入14项研究。Meta分析结果显示,在常规溶栓基础上加入针刺治疗可提高ACI患者的临床有效率(RR=1.19,95%CI[1.13,1.25]),降低美国国立卫生研究院卒中量表评分(MD=-3.51,95%CI[-4.54,-2.48]),改善Barthel指数(MD=12.26,95%CI[8.07,16.46]),并降低C反应蛋白水平(MD=-3.99,95%CI[-4.35,-3.63])。两组间血管完全再通率(RR=1.20,95%CI[1.00,1.44])、不良反应率(RR=0.76,95%CI[0.41,1.41])和出血性转化率(RR=0.72,95%CI[0.14,3.62])均差异无统计学意义。结论:当前有效证据表明,针刺在提高ACI溶栓的治疗效果及安全性方面具有一定的优势。展开更多
Alzheimer's disease(AD)is the main type of dementia affecting elderly people.The medicines used for treating AD have limits in their ability to alleviate cognitive and functional decline.Electroacupuncture(EA),an ...Alzheimer's disease(AD)is the main type of dementia affecting elderly people.The medicines used for treating AD have limits in their ability to alleviate cognitive and functional decline.Electroacupuncture(EA),an economical alternative and complementary therapeutic measure used in Chinese medicine,has strong clinical applicability,and its treatment effects are more reliable as its stimulation factors can be standardized.EA has been effectively used for ameliorating spatial learning and memory impairment in AD patients and rodent AD models.Here,we summarized the mechanisms of EA on rodent AD models,aiming to provide a theoretical basis for identifying new targets and research directions,and exploring appropriate EA stimulation parameters,then provide a detailed methodology to optimize the effects of EA,ultimately reducing the heavy burden of treating AD patients on families and countries.Our review showed that 8 acupoints were used when treating AD animals;Baihui(GV 20)was the most frequently used.Four mechanisms of EA were studied:(1)protection of cerebral neurons from oxidative stress,apoptosis,neuroinflammation,synaptic plasticity and hormone levels;(2)regulation of metabolism,including glucose metabolism and plasma metabolism;(3)regulation of brain derived neurotrophic factor;and(4)regulation of β-amyloid peptide protein deposition.展开更多
文摘目的:对针刺联合溶栓治疗急性脑梗死(ACI)的疗效及安全性进行系统评价。方法:检索PubMed、Cochrane Library、Embase、Web of Science、中国知网、万方、维普、中国生物医学文献数据库(CBM)中关于针刺联合溶栓治疗ACI的临床随机对照试验,检索时间为各库建库时间至2020年3月。由2名研究者根据纳入排除标准,独立对文献进行筛选,提取评估,并使用Revman 5.3软件对数据进行Meta分析。结果:共纳入14项研究。Meta分析结果显示,在常规溶栓基础上加入针刺治疗可提高ACI患者的临床有效率(RR=1.19,95%CI[1.13,1.25]),降低美国国立卫生研究院卒中量表评分(MD=-3.51,95%CI[-4.54,-2.48]),改善Barthel指数(MD=12.26,95%CI[8.07,16.46]),并降低C反应蛋白水平(MD=-3.99,95%CI[-4.35,-3.63])。两组间血管完全再通率(RR=1.20,95%CI[1.00,1.44])、不良反应率(RR=0.76,95%CI[0.41,1.41])和出血性转化率(RR=0.72,95%CI[0.14,3.62])均差异无统计学意义。结论:当前有效证据表明,针刺在提高ACI溶栓的治疗效果及安全性方面具有一定的优势。
基金Supported by the National Natural Science Foundation of China(No.81674067)。
文摘Alzheimer's disease(AD)is the main type of dementia affecting elderly people.The medicines used for treating AD have limits in their ability to alleviate cognitive and functional decline.Electroacupuncture(EA),an economical alternative and complementary therapeutic measure used in Chinese medicine,has strong clinical applicability,and its treatment effects are more reliable as its stimulation factors can be standardized.EA has been effectively used for ameliorating spatial learning and memory impairment in AD patients and rodent AD models.Here,we summarized the mechanisms of EA on rodent AD models,aiming to provide a theoretical basis for identifying new targets and research directions,and exploring appropriate EA stimulation parameters,then provide a detailed methodology to optimize the effects of EA,ultimately reducing the heavy burden of treating AD patients on families and countries.Our review showed that 8 acupoints were used when treating AD animals;Baihui(GV 20)was the most frequently used.Four mechanisms of EA were studied:(1)protection of cerebral neurons from oxidative stress,apoptosis,neuroinflammation,synaptic plasticity and hormone levels;(2)regulation of metabolism,including glucose metabolism and plasma metabolism;(3)regulation of brain derived neurotrophic factor;and(4)regulation of β-amyloid peptide protein deposition.
