Three title compounds(3~5) have been successfully synthesized via interactive reactions between ferrocenecarboxylic and dehydroabietic acids, which can be characterized by FT-IR, elemental analysis, ESI-MS, and NMR sp...Three title compounds(3~5) have been successfully synthesized via interactive reactions between ferrocenecarboxylic and dehydroabietic acids, which can be characterized by FT-IR, elemental analysis, ESI-MS, and NMR spectroscopy. The crystal structures of compounds 4 and 5 can be determined by single-crystal X-ray diffraction. Compound 4 is of orthorhombic system, space group P212121 with a = 7.7010(5), b = 11.7542(9), c = 28.3173(18) ?, Z = 4, V = 2563.3(3) ?~3, Mr = 512.45, Dc = 1.328 g/cm^(-1), S = 1.041, μ = 0.619 mm^(-1), F(000) = 1088, the final R = 0.0396 and wR = 0.0945 for 4394 observed reflections(I > 2σ(I)). Compound 5 crystallizes in orthorhombic system, space group P21212 as well, with parameters of a = 11.9875(15), b = 19.651(2), c = 7.2163(9) ?, Z = 2, V = 1699.9(3) ?~3, Mr = 582.83, Dc = 1.139 g/cm^(-1), S = 1.091, μ = 0.070 mm^(-1), F(000) = 636, the final R = 0.0653 and wR = 0.0719 for 1518 observed reflections(I > 2σ(I)). Additionally, electrochemical properties of compounds 3 and 4 have been investigated by the cyclic and differential pulse voltammogram techniques.展开更多
Identifying patients with high risk of death after myocardial infarction is a cornerstone of modern cardiovascular health care.The purpose of this study was to explore the predictive ability of N-terminal probrain nat...Identifying patients with high risk of death after myocardial infarction is a cornerstone of modern cardiovascular health care.The purpose of this study was to explore the predictive ability of N-terminal probrain natriuretic peptide(NT-pro-BNP)concentration and global acute coronary event register(GRACE)risk score in the prognosis of ST-segment elevation myocardial infarction(STEMI)patients,to find a better method for early risk stratification and prognosis judgment in the clinical diagnosis and treatment of STEMI patients,and to provide reliable clinical basis for making the best individualized treatment strategies for patients.Methods The final analysis included 118 confirmed STEMI patients who had received acute percutaneous coronary intervention(PCI).Thirty patients with STEMI were included in the major cardiac adverse events(MACEs)group,and the rest were included in the non-MACEs group.Multivariate Cox regression analysis was used to assess the relationship between the risk factors and MACEs.The receiver operator curves(ROC)were used to determine the area under the statistical curve(AUC).The linear correlation analysis confirmed the relationship between NT-proBNP concentration and GRACE score.Results After adjustment for sex,history of current smoking,hypertension,diabetes mellitus,cerebral artery disease and coronary artery vessel lesion(single-vessel lesion,2-vessel lesion,3-vessel lesion),onset time and medication,the multivariate Cox’s regression analysis showed that NT-proBNP concentration and GRACE score were the independent predictors for MACEs in STEMI patients who received PCI.Linear regression analysis showed that the level of NT-pro-BNP was positively correlated with GRACE score(r=0.612,P=0.000).The area under the curve(AUC)for GRACE,NT-pro-BNP and their combination were 0.757,0.723 and 0.782,respectively.Conclusions In a one-year follow-up,the concentration of NTpro-BNP and GRACE score were valuable of prediction for MACEs in STEMI patients who received PCI.In addition,NT-pro-BNP concentration was positively correlated with GRACE score.Additionally,the concentration of NT-pro-BNP could moderately enhance the GRACE score prediction of 1-year MACEs in STEMI patients who received PCI.展开更多
基金Support from the National Natural Science Foundation of China(21601087)the Topnotch Academic Programs Project(TAPP)the Priority Academic Program Development of Jiangsu Higher Education Institution(PAPD)。
文摘Three title compounds(3~5) have been successfully synthesized via interactive reactions between ferrocenecarboxylic and dehydroabietic acids, which can be characterized by FT-IR, elemental analysis, ESI-MS, and NMR spectroscopy. The crystal structures of compounds 4 and 5 can be determined by single-crystal X-ray diffraction. Compound 4 is of orthorhombic system, space group P212121 with a = 7.7010(5), b = 11.7542(9), c = 28.3173(18) ?, Z = 4, V = 2563.3(3) ?~3, Mr = 512.45, Dc = 1.328 g/cm^(-1), S = 1.041, μ = 0.619 mm^(-1), F(000) = 1088, the final R = 0.0396 and wR = 0.0945 for 4394 observed reflections(I > 2σ(I)). Compound 5 crystallizes in orthorhombic system, space group P21212 as well, with parameters of a = 11.9875(15), b = 19.651(2), c = 7.2163(9) ?, Z = 2, V = 1699.9(3) ?~3, Mr = 582.83, Dc = 1.139 g/cm^(-1), S = 1.091, μ = 0.070 mm^(-1), F(000) = 636, the final R = 0.0653 and wR = 0.0719 for 1518 observed reflections(I > 2σ(I)). Additionally, electrochemical properties of compounds 3 and 4 have been investigated by the cyclic and differential pulse voltammogram techniques.
基金supported by Hospital-level Project of The Second Affiliated Hospital of Xi’an Medical College(No.16KY0116)。
文摘Identifying patients with high risk of death after myocardial infarction is a cornerstone of modern cardiovascular health care.The purpose of this study was to explore the predictive ability of N-terminal probrain natriuretic peptide(NT-pro-BNP)concentration and global acute coronary event register(GRACE)risk score in the prognosis of ST-segment elevation myocardial infarction(STEMI)patients,to find a better method for early risk stratification and prognosis judgment in the clinical diagnosis and treatment of STEMI patients,and to provide reliable clinical basis for making the best individualized treatment strategies for patients.Methods The final analysis included 118 confirmed STEMI patients who had received acute percutaneous coronary intervention(PCI).Thirty patients with STEMI were included in the major cardiac adverse events(MACEs)group,and the rest were included in the non-MACEs group.Multivariate Cox regression analysis was used to assess the relationship between the risk factors and MACEs.The receiver operator curves(ROC)were used to determine the area under the statistical curve(AUC).The linear correlation analysis confirmed the relationship between NT-proBNP concentration and GRACE score.Results After adjustment for sex,history of current smoking,hypertension,diabetes mellitus,cerebral artery disease and coronary artery vessel lesion(single-vessel lesion,2-vessel lesion,3-vessel lesion),onset time and medication,the multivariate Cox’s regression analysis showed that NT-proBNP concentration and GRACE score were the independent predictors for MACEs in STEMI patients who received PCI.Linear regression analysis showed that the level of NT-pro-BNP was positively correlated with GRACE score(r=0.612,P=0.000).The area under the curve(AUC)for GRACE,NT-pro-BNP and their combination were 0.757,0.723 and 0.782,respectively.Conclusions In a one-year follow-up,the concentration of NTpro-BNP and GRACE score were valuable of prediction for MACEs in STEMI patients who received PCI.In addition,NT-pro-BNP concentration was positively correlated with GRACE score.Additionally,the concentration of NT-pro-BNP could moderately enhance the GRACE score prediction of 1-year MACEs in STEMI patients who received PCI.
