Background Stent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms.Metho...Background Stent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms.Methods Three idealized plexiglass aneudsmal models with different geometries before and after stenting were created, and their three-dimensional computational models were constructed. Flow dynamics in stented and unstented aneurismal models were studied using in vitro flow visualization and computational fluid dynamics （CFD） simulations. In addition, effects of stenting on flow dynamics in a patient-specific aneurysm model were also analyzed by CFD.Results The results of flow visualization were consistent with those obtained with CFD simulations. Stent deployment reduced vortex inside the aneurysm and its impact on the aneurysm sac, and decreased wall shear stress on the sac.Different aneurysm geometries dictated fundamentally different hemodynamic patterns and outcomes of stenting.Conclusions Stenting across the neck of aneurysms improves local blood flow profiles. This may facilitate thrombus formation in aneurysms and decrease the chance of recanalization.展开更多
文摘目的探讨总结新型冠状病毒(coronavirus disease-19,COVID-19)肺炎疫情时期急性缺血性卒中(acute ischemic stroke,AIS)的急诊取栓治疗经验。方法回顾性分析2020年1月20日-3月20日疫情期间,首都医科大学附属北京天坛医院神经介入中心进行急诊取栓治疗的AIS病例资料,包括患者的一般资料、NIHSS评分、ASPECTS评分(DWI)、病变部位、手术策略、恢复情况,以及COVID-19筛查、预防标准与流程。并与2019年1月20日-3月20日同期取栓病例进行对照分析。结果共纳入33例颅内大血管闭塞致AIS进行急诊取栓的患者,其中2020年18例,2019年15例。2020年疫情期间与2019年同期相比,入院到手术开始时间稍长[4.0(2.9~4.1)h vs 3.0(2.0~4.0)h,P=0.103],更少采用全身麻醉(55.6%vs 100.0%,P=0.003),更倾向采取直接导管抽吸取栓(27.8%vs 13.3%,P=0.32)。出院时死亡率低于2019年同期取栓患者(0 vs 20.0%,P=0.050)。2020年疫情期间纳入的患者及参与救治的医护人员无COVID-19可疑病例,无COVID-19疑似或确诊病例。结论COVID-19疫情期间,入院到手术开始时间受到疫情筛查的影响而有所延长,取栓策略倾向于采取局部麻醉、抽吸取栓策略,作为疫情期间的特殊考虑是合理的。
基金This study was supported by grants from the National Science Foundation of China （No. 30772234 and No. 10972016）, the Natural Science Foundation of Beijing （No. 7072016 and No. 3092004）, the Individual Item Assisted by Beijing Excellent Talents Program （No. 20061D0300400072）, and High Level Health Technique Talent Training Plan of Beijing Health System （No. 2009-3-22）.
文摘Background Stent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms.Methods Three idealized plexiglass aneudsmal models with different geometries before and after stenting were created, and their three-dimensional computational models were constructed. Flow dynamics in stented and unstented aneurismal models were studied using in vitro flow visualization and computational fluid dynamics （CFD） simulations. In addition, effects of stenting on flow dynamics in a patient-specific aneurysm model were also analyzed by CFD.Results The results of flow visualization were consistent with those obtained with CFD simulations. Stent deployment reduced vortex inside the aneurysm and its impact on the aneurysm sac, and decreased wall shear stress on the sac.Different aneurysm geometries dictated fundamentally different hemodynamic patterns and outcomes of stenting.Conclusions Stenting across the neck of aneurysms improves local blood flow profiles. This may facilitate thrombus formation in aneurysms and decrease the chance of recanalization.
