目的:系统评价Ki67表达比例对乳腺癌患者预后的影响,尤其是对无病生存期(DFS)的影响。为临床应用提供循证医学依据。方法:计算机检索PubMed、Embase、Web of Science、Cochrane Library、中国期刊全文数据库(CNKI)、维普数据库(VIP)、...目的:系统评价Ki67表达比例对乳腺癌患者预后的影响,尤其是对无病生存期(DFS)的影响。为临床应用提供循证医学依据。方法:计算机检索PubMed、Embase、Web of Science、Cochrane Library、中国期刊全文数据库(CNKI)、维普数据库(VIP)、万方数据库以及中国生物医学文献数据库(CBM)。应用RevMan 5.3软件对所纳入的数据进行统计学分析。结果:共纳入8篇文献,合计15 643例患者。Meta分析结果显示,纳入文献中的Ki67高比例表达组患者的DFS(HR=1.86,95%CI=1.31~2.65)要低于Ki67低比例表达组,差异有统计学意义。亚组分析中,以种族分亚组的结果与上述类似,差异也有统计学意义;以Ki67表达临界值分亚组,Ki67表达临界值为30%的亚组差异没有统计学意义,表达临界值为其他值的亚组差异有统计学意义。结论:本研究Meta分析显示,Ki67是乳腺癌的一种不良预后因子,Ki67高比例表达的患者有着更低的DFS。展开更多
This paper introduces China's New Third Board Market(the NTB market) and tests the market-making system in the role of improving market liquidity. The NTB Market is the main part of China's OTC market, established...This paper introduces China's New Third Board Market(the NTB market) and tests the market-making system in the role of improving market liquidity. The NTB Market is the main part of China's OTC market, established in 2006. In comparing with China's Main Board Market and the Second Board Market, it attracts a lot of start-up companies that need financing with less strict listing requirements. Meanwhile, it is full of opportunities and challenges that appeal to numerous securities traders and investors with the rapid development momentum. Since its establishment, the NTB Market has been stuck in the lack of liquidity. The authority of the NTB Market introduced market maker system, so as to solve the problem of liquidity. Using the difference-in-difference method(DID method), the market maker system has been proved to make little contribution to improving the stock liquidity. Although the problem of liquidity is difficult to solve in short term, the NTB Market is full of opportunities for all kinds of participants definitely.展开更多
基金funded by the National Natural Science Foundation of China under Grant No.71572093
文摘This paper introduces China's New Third Board Market(the NTB market) and tests the market-making system in the role of improving market liquidity. The NTB Market is the main part of China's OTC market, established in 2006. In comparing with China's Main Board Market and the Second Board Market, it attracts a lot of start-up companies that need financing with less strict listing requirements. Meanwhile, it is full of opportunities and challenges that appeal to numerous securities traders and investors with the rapid development momentum. Since its establishment, the NTB Market has been stuck in the lack of liquidity. The authority of the NTB Market introduced market maker system, so as to solve the problem of liquidity. Using the difference-in-difference method(DID method), the market maker system has been proved to make little contribution to improving the stock liquidity. Although the problem of liquidity is difficult to solve in short term, the NTB Market is full of opportunities for all kinds of participants definitely.