目的:观察重建锁定接骨板联合股骨近端防旋髓内钉(proximal femoral nail antirotation,PFNA)内固定治疗合并外侧壁破裂的A3型老年股骨转子间骨折的临床疗效和安全性。方法:回顾性分析40例合并外侧壁破裂的A3型老年股骨转子间骨折患者...目的:观察重建锁定接骨板联合股骨近端防旋髓内钉(proximal femoral nail antirotation,PFNA)内固定治疗合并外侧壁破裂的A3型老年股骨转子间骨折的临床疗效和安全性。方法:回顾性分析40例合并外侧壁破裂的A3型老年股骨转子间骨折患者的病例资料,其中采用重建锁定接骨板联合PFNA内固定治疗20例(重建锁定接骨板联合PFNA组)、单纯采用PFNA内固定治疗20例(PFNA组)。比较2组患者手术时间、术中出血量、住院时间、术后下地时间、骨折愈合时间、股骨偏心距短缩、尖顶距、Harris髋关节评分及并发症发生率。结果:①一般结果。2组患者手术时间、术中出血量比较,组间差异均无统计学意义[(114.12±12.52)min,(105.24±10.61)min,t=1.724,P=0.062;(309.12±18.37)mL,(278.55±20.14)mL,t=1.956,P=0.059];重建锁定接骨板联合PFNA组患者住院时间、术后下地时间均短于PFNA组[(11.0±1.5)d,(17.3±2.3)d,t=2.510,P=0.041;(26.4±5.5)d,(41.0±6.2)d,t=2.131,P=0.012]。②疗效评价结果。重建锁定接骨板联合PFNA组患者骨折愈合时间短于PFNA组[(9.8±1.2)周,(13.6±3.1)周,t=2.371,P=0.036];股骨偏心距短缩小于PFNA组[(0.3±0.2)mm,(0.8±0.1)mm,t=1.658,P=0.020];2组患者尖顶距比较,差异无统计学意义[(26.7±4.1)mm,(27.7±3.4)mm,t=0.245,P=0.120]。2组患者随访时间6~12个月,中位数7.5个月。末次随访时,重建锁定接骨板联合PFNA组患者Harris髋关节评分高于PFNA组[(91.1±6.6)分,(83.1±6.4)分,t=3.036,P=0.005]。③安全性评价结果。重建锁定接骨板联合PFNA组1例发生主钉轻度上移,PFNA组2例发生主钉轻度上移、2例发生螺旋刀片后退及切出、1例发生主钉断裂。2组患者并发症发生率比较,差异无统计学意义(P=0.091)。结论:重建锁定接骨板联合PFNA内固定治疗合并外侧壁破裂的A3型老年股骨转子间骨折,与单纯PFNA内固定比较,患者下地活动早,住院时间和骨折愈合时间短,髋关节功能恢复好,且安全性相当。展开更多
The moral connotation of solidly promoting common prosperity for all people in the new era has been formed in the interaction between history and practice.It features the full coverage of the subjects of common prospe...The moral connotation of solidly promoting common prosperity for all people in the new era has been formed in the interaction between history and practice.It features the full coverage of the subjects of common prosperity,the richness of the content,the gradualness of the process,and the authenticity of the practice.As the core structural elements,the three units of consciousness,namely,the moral logic of putting people first,the moral model of coordinated development,and the moral ideal of coexistence,form the organic whole of the moral pattern of solidly promoting common prosperity for all people in the new era.The moral practice of solidly promoting common prosperity for all people in the new era refers to the maximum realization of the value and dignity of human survival and development.The pursuit of high-quality development is also the striving for common prosperity,the pioneering spirit and collective consciousness highlighted in the construction of the demonstration zones for realizing common prosperity,and the role of the third distribution and the upholding of fairness and justice have vividly demonstrated the moral practice of solidly promoting common prosperity for all people in the new era.展开更多
In this study,37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated,building upon our previous synthesis of 51 phorbol derivatives.12-Para-electron-acceptor-trans-cinnamoyl-13-dec...In this study,37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated,building upon our previous synthesis of 51 phorbol derivatives.12-Para-electron-acceptor-trans-cinnamoyl-13-decanoyl phorbol derivatives stood out,demonstrating remarkable anti-HIV-1 activities and inhibitory effects on syncytia formation.These derivatives exhibited a higher safety index compared with the positive control drug.Among them,12-(trans-4-fluorocinnamoyl)-13-decanoyl phorbol,designated as compound 3c,exhibited the most potent anti-HIV-1 activity(EC_(50)2.9 nmol·L^(−1),CC50/EC_(50)11117.24)and significantly inhibited the formation of syncytium(EC_(50)7.0 nmol·L^(−1),CC50/EC_(50)4891.43).Moreover,compound 3c is hypothesized to act both as an HIV-1 entry inhibitor and as an HIV-1 reverse transcriptase inhibitor.Isothermal titration calorimetry and molecular docking studies indicated that compound 3c may also function as a natural activator of protein kinase C(PKC).Therefore,compound 3c emerges as a potential candidate for developing new anti-HIV drugs.展开更多
文摘目的:观察重建锁定接骨板联合股骨近端防旋髓内钉(proximal femoral nail antirotation,PFNA)内固定治疗合并外侧壁破裂的A3型老年股骨转子间骨折的临床疗效和安全性。方法:回顾性分析40例合并外侧壁破裂的A3型老年股骨转子间骨折患者的病例资料,其中采用重建锁定接骨板联合PFNA内固定治疗20例(重建锁定接骨板联合PFNA组)、单纯采用PFNA内固定治疗20例(PFNA组)。比较2组患者手术时间、术中出血量、住院时间、术后下地时间、骨折愈合时间、股骨偏心距短缩、尖顶距、Harris髋关节评分及并发症发生率。结果:①一般结果。2组患者手术时间、术中出血量比较,组间差异均无统计学意义[(114.12±12.52)min,(105.24±10.61)min,t=1.724,P=0.062;(309.12±18.37)mL,(278.55±20.14)mL,t=1.956,P=0.059];重建锁定接骨板联合PFNA组患者住院时间、术后下地时间均短于PFNA组[(11.0±1.5)d,(17.3±2.3)d,t=2.510,P=0.041;(26.4±5.5)d,(41.0±6.2)d,t=2.131,P=0.012]。②疗效评价结果。重建锁定接骨板联合PFNA组患者骨折愈合时间短于PFNA组[(9.8±1.2)周,(13.6±3.1)周,t=2.371,P=0.036];股骨偏心距短缩小于PFNA组[(0.3±0.2)mm,(0.8±0.1)mm,t=1.658,P=0.020];2组患者尖顶距比较,差异无统计学意义[(26.7±4.1)mm,(27.7±3.4)mm,t=0.245,P=0.120]。2组患者随访时间6~12个月,中位数7.5个月。末次随访时,重建锁定接骨板联合PFNA组患者Harris髋关节评分高于PFNA组[(91.1±6.6)分,(83.1±6.4)分,t=3.036,P=0.005]。③安全性评价结果。重建锁定接骨板联合PFNA组1例发生主钉轻度上移,PFNA组2例发生主钉轻度上移、2例发生螺旋刀片后退及切出、1例发生主钉断裂。2组患者并发症发生率比较,差异无统计学意义(P=0.091)。结论:重建锁定接骨板联合PFNA内固定治疗合并外侧壁破裂的A3型老年股骨转子间骨折,与单纯PFNA内固定比较,患者下地活动早,住院时间和骨折愈合时间短,髋关节功能恢复好,且安全性相当。
基金the phased research result of the major research project“A study on the century-long history of the CPC seeking happiness for the Chinese people”on the guiding principles of the Sixth Plenary Session of the 19th CPC Central Committee in 2022 of Guangdong Province’s Philosophy and Social Sciences Planning(Approval No.GD22ZDZ01-05)。
文摘The moral connotation of solidly promoting common prosperity for all people in the new era has been formed in the interaction between history and practice.It features the full coverage of the subjects of common prosperity,the richness of the content,the gradualness of the process,and the authenticity of the practice.As the core structural elements,the three units of consciousness,namely,the moral logic of putting people first,the moral model of coordinated development,and the moral ideal of coexistence,form the organic whole of the moral pattern of solidly promoting common prosperity for all people in the new era.The moral practice of solidly promoting common prosperity for all people in the new era refers to the maximum realization of the value and dignity of human survival and development.The pursuit of high-quality development is also the striving for common prosperity,the pioneering spirit and collective consciousness highlighted in the construction of the demonstration zones for realizing common prosperity,and the role of the third distribution and the upholding of fairness and justice have vividly demonstrated the moral practice of solidly promoting common prosperity for all people in the new era.
基金supported by the National Natural Science Foundation of China(Nos.81202882,82060670)Suzhou Science and Technology Planning Project in Jiangsu Province of China(No.SNG2021022)+1 种基金the Priority Academic Program Development of the Jiangsu Higher Education Institutes,China(PAPD)and the Project of Innovative Research Team of Yunnan Province(No.202005AE160005).
文摘In this study,37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated,building upon our previous synthesis of 51 phorbol derivatives.12-Para-electron-acceptor-trans-cinnamoyl-13-decanoyl phorbol derivatives stood out,demonstrating remarkable anti-HIV-1 activities and inhibitory effects on syncytia formation.These derivatives exhibited a higher safety index compared with the positive control drug.Among them,12-(trans-4-fluorocinnamoyl)-13-decanoyl phorbol,designated as compound 3c,exhibited the most potent anti-HIV-1 activity(EC_(50)2.9 nmol·L^(−1),CC50/EC_(50)11117.24)and significantly inhibited the formation of syncytium(EC_(50)7.0 nmol·L^(−1),CC50/EC_(50)4891.43).Moreover,compound 3c is hypothesized to act both as an HIV-1 entry inhibitor and as an HIV-1 reverse transcriptase inhibitor.Isothermal titration calorimetry and molecular docking studies indicated that compound 3c may also function as a natural activator of protein kinase C(PKC).Therefore,compound 3c emerges as a potential candidate for developing new anti-HIV drugs.
