目的探讨Toll样受体4(Toll like reseptor4,TLR4)/核因子κB(nuclear factor kappaB,NF-κB)炎症通路与手足口病病原和严重程度的关系。方法选择手足口病患儿78例,按病原体分为EV71感染手足口病组34例和非EV71感染手足口病组44例;按是...目的探讨Toll样受体4(Toll like reseptor4,TLR4)/核因子κB(nuclear factor kappaB,NF-κB)炎症通路与手足口病病原和严重程度的关系。方法选择手足口病患儿78例,按病原体分为EV71感染手足口病组34例和非EV71感染手足口病组44例;按是否存在神经系统并发症分为手足口病普通型组47例和手足口病重症型组31例。另选择同期体格检查健康儿童35例。采用酶联免疫吸附测定法检测所有受试者外周血TLR4和NF-κB含量,分析手足口病肠道病毒分型和严重程度与外周血TLR4和NF-κB的关系。结果EV71组和非EV71组外周血中TLR4和NF-κB含量高于对照组,EV71组外周血中TLR4和NF-κB含量高于非EV71组(P<0.05);重症型组外周血TLR4和NF-κB含量高于普通型组(P<0.05)。手足口病病原和严重程度与外周血TLR4和NF-κB含量均呈正相关(P<0.05)。控制变数病情轻重后,非EV71组和EV71组与手足口患儿外周血TLR4和NF-κB含量呈正相关(P<0.05)。结论EV71感染手足口病与TLR4/NF-κB炎症信号通路的发生发展以及严重程度相关。展开更多
A proper edge coloring of a graph G is called adjacent vertex-distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the coloring set of edges incident with u is not equal to the coloring set of ...A proper edge coloring of a graph G is called adjacent vertex-distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the coloring set of edges incident with u is not equal to the coloring set of edges incident with v, where uv∈ E（G）. The adjacent vertex distinguishing acyclic edge chromatic number of G, denoted by X＇Aa（G）, is the minimal number of colors in an adjacent vertex distinguishing acyclic edge coloring of G. If a graph G has an adjacent vertex distinguishing acyclic edge coloring, then G is called adjacent vertex distinguishing acyclic. In this paper, we obtain adjacent vertex-distinguishing acyclic edge coloring of some graphs and put forward some conjectures.展开更多
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9)基因编辑技术是基于细菌和古细菌适应性免疫防御系统发展而来的一种基因编辑工具。Cas9蛋白借助gRNA的引导靶向目标基因进而实现...CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9)基因编辑技术是基于细菌和古细菌适应性免疫防御系统发展而来的一种基因编辑工具。Cas9蛋白借助gRNA的引导靶向目标基因进而实现对目标基因精确、高效的编辑。因其具有操作简单、成本低的特点,被研究人员广泛应用,并在前列腺癌相关基因及信号通路的研究中发挥着重要作用。该文将对CRISPR/Cas9基因编辑技术的发展、作用机理及其在前列腺癌研究中的应用进展进行综述。展开更多
文摘目的探讨Toll样受体4(Toll like reseptor4,TLR4)/核因子κB(nuclear factor kappaB,NF-κB)炎症通路与手足口病病原和严重程度的关系。方法选择手足口病患儿78例,按病原体分为EV71感染手足口病组34例和非EV71感染手足口病组44例;按是否存在神经系统并发症分为手足口病普通型组47例和手足口病重症型组31例。另选择同期体格检查健康儿童35例。采用酶联免疫吸附测定法检测所有受试者外周血TLR4和NF-κB含量,分析手足口病肠道病毒分型和严重程度与外周血TLR4和NF-κB的关系。结果EV71组和非EV71组外周血中TLR4和NF-κB含量高于对照组,EV71组外周血中TLR4和NF-κB含量高于非EV71组(P<0.05);重症型组外周血TLR4和NF-κB含量高于普通型组(P<0.05)。手足口病病原和严重程度与外周血TLR4和NF-κB含量均呈正相关(P<0.05)。控制变数病情轻重后,非EV71组和EV71组与手足口患儿外周血TLR4和NF-κB含量呈正相关(P<0.05)。结论EV71感染手足口病与TLR4/NF-κB炎症信号通路的发生发展以及严重程度相关。
基金supported by NSFC of China (No. 19871036 and No. 40301037)Faculty Research Grant,Hong Kong Baptist University
文摘A proper edge coloring of a graph G is called adjacent vertex-distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the coloring set of edges incident with u is not equal to the coloring set of edges incident with v, where uv∈ E（G）. The adjacent vertex distinguishing acyclic edge chromatic number of G, denoted by X＇Aa（G）, is the minimal number of colors in an adjacent vertex distinguishing acyclic edge coloring of G. If a graph G has an adjacent vertex distinguishing acyclic edge coloring, then G is called adjacent vertex distinguishing acyclic. In this paper, we obtain adjacent vertex-distinguishing acyclic edge coloring of some graphs and put forward some conjectures.
文摘CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9)基因编辑技术是基于细菌和古细菌适应性免疫防御系统发展而来的一种基因编辑工具。Cas9蛋白借助gRNA的引导靶向目标基因进而实现对目标基因精确、高效的编辑。因其具有操作简单、成本低的特点,被研究人员广泛应用,并在前列腺癌相关基因及信号通路的研究中发挥着重要作用。该文将对CRISPR/Cas9基因编辑技术的发展、作用机理及其在前列腺癌研究中的应用进展进行综述。
