Cancer is one of the most common diseases to threaten human health.If individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malig...Cancer is one of the most common diseases to threaten human health.If individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malignant tumors therapy.In this paper,we propose a fluorescence detection map to rapidly distinguish whether the chromosomes of a cell are normal or abnormal by detecting the fluorescent intensity of a single cell.Herein,we draw a map from a single cell with an abnormal number of chromosomes that is monitored in real time.Moreover,this way offers precise and prompt detection of the surviving of cancer cells at or near the site of the tumor after treatments for cancer,which can achieve personalized cancer diagnosis and therapy.Therefore,cancer recurrences and metastasis can be effectively identified,utilizing this ultrasensitive detection method of an abnormal chromosome number.展开更多
基金Shanghai Municipal Science and Technology Major Project(2019SHZDZX01)Foundation for Development of Science and Technology of Shanghai(17JC1400400)+2 种基金fellowship of China Postdoctoral Science Foundation(2020M681275,2021T140452)National Natural Science Foundation of China(11734011,11764020,11974245)National Key R&D Program of China(2017YFA0303701,2018YFA0306301)。
文摘Cancer is one of the most common diseases to threaten human health.If individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malignant tumors therapy.In this paper,we propose a fluorescence detection map to rapidly distinguish whether the chromosomes of a cell are normal or abnormal by detecting the fluorescent intensity of a single cell.Herein,we draw a map from a single cell with an abnormal number of chromosomes that is monitored in real time.Moreover,this way offers precise and prompt detection of the surviving of cancer cells at or near the site of the tumor after treatments for cancer,which can achieve personalized cancer diagnosis and therapy.Therefore,cancer recurrences and metastasis can be effectively identified,utilizing this ultrasensitive detection method of an abnormal chromosome number.
