[Objective] The aim was to study the rainstorm process in a single station on July 19, 2010. [Method] Based on MICAPS conventional data and Doppler radar data, the rainstorm process in Dagang station in Tianjin on Jul...[Objective] The aim was to study the rainstorm process in a single station on July 19, 2010. [Method] Based on MICAPS conventional data and Doppler radar data, the rainstorm process in Dagang station in Tianjin on July 19, 2010 was analyzed systematically by means of weather dynamic diagnosis analysis. [Result] From physical vector diagnostic analysis, the dynamic effect provided by southwest vortex and warm shear line, water vapor transported by warm and wet flow at the edge of subtropical high and upper and lower jet and unstable convection of atmospheric stratification were the main causes of rainstorm formation on July 19, 2010. In addition, rainfall area was located in the big convergence area of vapor flux, and there was a negative center of vapor flux divergence before rainfall, with obvious accumulation of water vapor, which provided better water vapor condition for this rainstorm. [Conclusion] The study could provide theoretical foundation for the forecast of rainstorm in Tianjin.展开更多
目的:探究IL-33/HMGB-1在胎鼠伤口愈合中的作用。方法:构建小鼠伤口愈合模型,并随机分组为注射PBS组、注射重组蛋白IL-33组和重组蛋白HMGB-1组。通过免疫组织化学、DAB和苏木精复染方法检测IL-33/HMGB-1的表达及定位;结合Axiovision软...目的:探究IL-33/HMGB-1在胎鼠伤口愈合中的作用。方法:构建小鼠伤口愈合模型,并随机分组为注射PBS组、注射重组蛋白IL-33组和重组蛋白HMGB-1组。通过免疫组织化学、DAB和苏木精复染方法检测IL-33/HMGB-1的表达及定位;结合Axiovision软件计算MOMA-2阳性巨噬细胞、波形蛋白阳性成纤维细胞和血管密度;通过Masson's三色染色评估伤口胶原蛋白的沉积情况和愈合情况。结果:E15和E18胎鼠未损伤皮肤的基底角质形成细胞核均呈阳性染色;与E15胎鼠相比,E18胎鼠皮肤中HMGB-1和IL-33的表达水平升高(P<0.05)。处理0h-48h,E15和E18胎鼠伤口边缘附近角质形成细胞的核染色呈降低,IL-33和HMGB-1表达水平均降低(P<0.05)。Masson三色染色结果显示,与PBS组相比,当采取200 ng或400 ng HMGB-1或.IL-33处理,E15胎鼠伤口愈合形成疤痕的数量均显著增加(P<0.05),且疤痕大小呈剂量依赖性增加(P<0.05)。创伤后7d,与PBS组相比,HMGB-1和IL-33处理的E15胎鼠伤口和瘢痕中波形蛋白阳性成纤维细胞、MOMA-2阳性巨噬细胞的数量和PECAM阳性血管密度均显著升高(P<0.01)。结论:IL-33/HMGB-1可以促进胎鼠伤口瘢痕的形成,其可能机制包括对成纤维细胞的直接刺激,以及与伤口中血管生成和巨噬细胞募集增加有关。展开更多
文摘[Objective] The aim was to study the rainstorm process in a single station on July 19, 2010. [Method] Based on MICAPS conventional data and Doppler radar data, the rainstorm process in Dagang station in Tianjin on July 19, 2010 was analyzed systematically by means of weather dynamic diagnosis analysis. [Result] From physical vector diagnostic analysis, the dynamic effect provided by southwest vortex and warm shear line, water vapor transported by warm and wet flow at the edge of subtropical high and upper and lower jet and unstable convection of atmospheric stratification were the main causes of rainstorm formation on July 19, 2010. In addition, rainfall area was located in the big convergence area of vapor flux, and there was a negative center of vapor flux divergence before rainfall, with obvious accumulation of water vapor, which provided better water vapor condition for this rainstorm. [Conclusion] The study could provide theoretical foundation for the forecast of rainstorm in Tianjin.
文摘目的:探究IL-33/HMGB-1在胎鼠伤口愈合中的作用。方法:构建小鼠伤口愈合模型,并随机分组为注射PBS组、注射重组蛋白IL-33组和重组蛋白HMGB-1组。通过免疫组织化学、DAB和苏木精复染方法检测IL-33/HMGB-1的表达及定位;结合Axiovision软件计算MOMA-2阳性巨噬细胞、波形蛋白阳性成纤维细胞和血管密度;通过Masson's三色染色评估伤口胶原蛋白的沉积情况和愈合情况。结果:E15和E18胎鼠未损伤皮肤的基底角质形成细胞核均呈阳性染色;与E15胎鼠相比,E18胎鼠皮肤中HMGB-1和IL-33的表达水平升高(P<0.05)。处理0h-48h,E15和E18胎鼠伤口边缘附近角质形成细胞的核染色呈降低,IL-33和HMGB-1表达水平均降低(P<0.05)。Masson三色染色结果显示,与PBS组相比,当采取200 ng或400 ng HMGB-1或.IL-33处理,E15胎鼠伤口愈合形成疤痕的数量均显著增加(P<0.05),且疤痕大小呈剂量依赖性增加(P<0.05)。创伤后7d,与PBS组相比,HMGB-1和IL-33处理的E15胎鼠伤口和瘢痕中波形蛋白阳性成纤维细胞、MOMA-2阳性巨噬细胞的数量和PECAM阳性血管密度均显著升高(P<0.01)。结论:IL-33/HMGB-1可以促进胎鼠伤口瘢痕的形成,其可能机制包括对成纤维细胞的直接刺激,以及与伤口中血管生成和巨噬细胞募集增加有关。
