After crossing Yuanjiang Bridge on the old National Highway 213,14 wild Asian elephants wandered deep into the forests on the south side of the Yuanjiang River in Yunnan Province.When drones tracking the herd sent bac...After crossing Yuanjiang Bridge on the old National Highway 213,14 wild Asian elephants wandered deep into the forests on the south side of the Yuanjiang River in Yunnan Province.When drones tracking the herd sent back real-time pictures of the elephants successfully making it back across the Yuanjiang River,protection staff burst into cheers.The successful crossing of the Yuanjiang Bridge represented the elephants overcoming the biggest obstacle on the journey back home after straying nearly 500 kilometers north of their original habitat.As the adventures of the wild elephants became international news,many joined efforts to ensure the herd returned home safely and soundly while inflicting minimal damage along the way.展开更多
Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite ...Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite (icariin-CS/HA) using freeze-drying technigue. Characteristics of morphology, mechanical properties, biocompatibility, drug release behavior and bone repair abilities in vivo were evaluated. The results show that drug loading process of icariin did not affect physical structure of CS/HA composite significantly but decreased mechanical properies of CS/HA composite, which happened with a high dosage; icariin-CS/HA had favorable cell compatibility and promoted osteogenic differentiation of hBMSCs; the controlled release of icariin was satisfactory and the release retained after 90 d in vitro. In addition, icariin-CS/HA scaffolds had favorable osteoconduction and osteoinduction in vivo, and could fill bone defect sites and stimulate newborn bone tissues formation at early stage. On the basis of these data, icariin-CS/HA is believed to be an optical bone repair scaffold for tissue engineering.展开更多
文摘After crossing Yuanjiang Bridge on the old National Highway 213,14 wild Asian elephants wandered deep into the forests on the south side of the Yuanjiang River in Yunnan Province.When drones tracking the herd sent back real-time pictures of the elephants successfully making it back across the Yuanjiang River,protection staff burst into cheers.The successful crossing of the Yuanjiang Bridge represented the elephants overcoming the biggest obstacle on the journey back home after straying nearly 500 kilometers north of their original habitat.As the adventures of the wild elephants became international news,many joined efforts to ensure the herd returned home safely and soundly while inflicting minimal damage along the way.
基金Supported by the National Basic Research Program (Grant No. 2009CB930000)National Natural Science Foundation of China (Grant No. 30700180)Chinese Postdoctoral Science Foundation (Grant No. 20060390206)
文摘Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite (icariin-CS/HA) using freeze-drying technigue. Characteristics of morphology, mechanical properties, biocompatibility, drug release behavior and bone repair abilities in vivo were evaluated. The results show that drug loading process of icariin did not affect physical structure of CS/HA composite significantly but decreased mechanical properies of CS/HA composite, which happened with a high dosage; icariin-CS/HA had favorable cell compatibility and promoted osteogenic differentiation of hBMSCs; the controlled release of icariin was satisfactory and the release retained after 90 d in vitro. In addition, icariin-CS/HA scaffolds had favorable osteoconduction and osteoinduction in vivo, and could fill bone defect sites and stimulate newborn bone tissues formation at early stage. On the basis of these data, icariin-CS/HA is believed to be an optical bone repair scaffold for tissue engineering.
