小驳骨为爵床科药用植物,具有祛瘀止痛、续筋接骨的功效,长期以来被用于跌打损伤、筋伤骨折、风湿骨痛、血瘀经闭和产后腹痛等疾病的治疗。通过搜索中国知网、PubMed、Web of Science等数据库,查找国内外已经发表的小驳骨相关文献,对小...小驳骨为爵床科药用植物,具有祛瘀止痛、续筋接骨的功效,长期以来被用于跌打损伤、筋伤骨折、风湿骨痛、血瘀经闭和产后腹痛等疾病的治疗。通过搜索中国知网、PubMed、Web of Science等数据库,查找国内外已经发表的小驳骨相关文献,对小驳骨近二十年的化学成分和生物活性研究进行系统地梳理、归纳,发现目前已从小驳骨中分离出超过100种化合物,包括萜类、黄酮类、苯丙素类、木质素类、香豆素类和生物碱等。小驳骨提取物具有显著的生物活性,如抗炎、抗氧化等,其抗炎作用机制可能与调节炎症因子水平、抑制相关信号通路或相关蛋白表达等有关。可为小驳骨资源后续深入系统地研究和临床开发提供科学依据和理论参考。展开更多
Although accelerated urbanization has led to economic prosperity,it has also resulted in urban heat island effects.Therefore,identifying methods of using limited urban spaces to alleviate heat islands has become an ur...Although accelerated urbanization has led to economic prosperity,it has also resulted in urban heat island effects.Therefore,identifying methods of using limited urban spaces to alleviate heat islands has become an urgent issue.In this study,we assessed the spatiotemporal evolution of urban heat islands within the central urban area of Fuzhou City,China from 2010 to 2019.This assessment was based on a morphological spatial pattern analysis(MSPA)model and an urban thermal environment spatial network constructed us-ing the minimum cumulative resistance(MCR)model.Optimization measures for the spatial network were proposed to provide a theor-etical basis for alleviating urban heat islands.The results show that the heat island area within the study area gradually increased while that of urban cold island area gradually decreased.The core area was the largest of the urban heat island patch landscape elements with a significant impact on other landscape elements,and represented an important factor underlying urban heat island network stability.The thermal environment network revealed a total of 197 thermal environment corridors and 93 heat island sources.These locations were then optimized according to the current land use,which maximized the potential of 1599.83 ha.Optimization based on current land use led to an increase in climate resilience,with effective measures showing reduction in thermal environment spatial network structure and function,contributing to the mitigation of urban heat island.These findings support the use of current land use patterns during urban heat island mitigation measure planning,thus providing an important reference basis for alleviating urban heat island effects.展开更多
目的通过随机对照试验,探寻与分析药物治疗管理(MTM)服务对急性缺血性脑卒中(以下简称脑卒中)患者依从性及预后的影响。方法对北京某三甲医院2018年5月至2019年7月的脑卒中患者进行MTM服务,共纳入134例患者,MTM组66例,对照组68例,整理...目的通过随机对照试验,探寻与分析药物治疗管理(MTM)服务对急性缺血性脑卒中(以下简称脑卒中)患者依从性及预后的影响。方法对北京某三甲医院2018年5月至2019年7月的脑卒中患者进行MTM服务,共纳入134例患者,MTM组66例,对照组68例,整理并记录患者的一般情况、疾病、用药情况,通过Morisky调查问卷,记录患者依从性基线及改变情况,同时记录服务前后患者美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分与日常生活能力评分(Activities of daily living,ADL)情况,分析药师干预对患者依从性及疾病预后的影响。结果两组在平均年龄、伴发疾病、初始用药品种方面差异均无统计学意义。Morisky评分:MTM组服务前后分别为(4.90±1.36)分、(5.68±1.19)分,对照组分别为(4.74±1.64)分、(4.79±1.75)分,P=0.01;NIHSS评分:MTM组服务前后分别为(2.83±3.12)分、(1.35±1.66)分,对照组分别为(3.01±3.47)分、(2.29±3.29)分,P=0.03;ADL评分:MTM组服务前后分别为(83.48±18.35)分、(91.44±12.18)分,对照组分别为(79.85±24.12)分、(84.33±23.47)分,P=0.03。两组服务前Morisky评分、NIHSS评分、ADL评分比较差异均无统计学意义(P>0.05),服务后评分比较差异有统计学意义(P<0.05)。结论临床药师开展MTM服务,能够提高患者的依从性,对合理用药、改善患者生活方式、改善脑卒中患者的疾病预后均具有积极意义。展开更多
文摘小驳骨为爵床科药用植物,具有祛瘀止痛、续筋接骨的功效,长期以来被用于跌打损伤、筋伤骨折、风湿骨痛、血瘀经闭和产后腹痛等疾病的治疗。通过搜索中国知网、PubMed、Web of Science等数据库,查找国内外已经发表的小驳骨相关文献,对小驳骨近二十年的化学成分和生物活性研究进行系统地梳理、归纳,发现目前已从小驳骨中分离出超过100种化合物,包括萜类、黄酮类、苯丙素类、木质素类、香豆素类和生物碱等。小驳骨提取物具有显著的生物活性,如抗炎、抗氧化等,其抗炎作用机制可能与调节炎症因子水平、抑制相关信号通路或相关蛋白表达等有关。可为小驳骨资源后续深入系统地研究和临床开发提供科学依据和理论参考。
基金Under the auspices of Special Funds for Education and Scientific Research of the Department of Finance(Min Cai Zhi[2022]No.840)Fujian Province Key Laboratory of Geographic Information Technology and Resource Optimization Construction Project(No.PTJH17014)。
文摘Although accelerated urbanization has led to economic prosperity,it has also resulted in urban heat island effects.Therefore,identifying methods of using limited urban spaces to alleviate heat islands has become an urgent issue.In this study,we assessed the spatiotemporal evolution of urban heat islands within the central urban area of Fuzhou City,China from 2010 to 2019.This assessment was based on a morphological spatial pattern analysis(MSPA)model and an urban thermal environment spatial network constructed us-ing the minimum cumulative resistance(MCR)model.Optimization measures for the spatial network were proposed to provide a theor-etical basis for alleviating urban heat islands.The results show that the heat island area within the study area gradually increased while that of urban cold island area gradually decreased.The core area was the largest of the urban heat island patch landscape elements with a significant impact on other landscape elements,and represented an important factor underlying urban heat island network stability.The thermal environment network revealed a total of 197 thermal environment corridors and 93 heat island sources.These locations were then optimized according to the current land use,which maximized the potential of 1599.83 ha.Optimization based on current land use led to an increase in climate resilience,with effective measures showing reduction in thermal environment spatial network structure and function,contributing to the mitigation of urban heat island.These findings support the use of current land use patterns during urban heat island mitigation measure planning,thus providing an important reference basis for alleviating urban heat island effects.
文摘目的通过随机对照试验,探寻与分析药物治疗管理(MTM)服务对急性缺血性脑卒中(以下简称脑卒中)患者依从性及预后的影响。方法对北京某三甲医院2018年5月至2019年7月的脑卒中患者进行MTM服务,共纳入134例患者,MTM组66例,对照组68例,整理并记录患者的一般情况、疾病、用药情况,通过Morisky调查问卷,记录患者依从性基线及改变情况,同时记录服务前后患者美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分与日常生活能力评分(Activities of daily living,ADL)情况,分析药师干预对患者依从性及疾病预后的影响。结果两组在平均年龄、伴发疾病、初始用药品种方面差异均无统计学意义。Morisky评分:MTM组服务前后分别为(4.90±1.36)分、(5.68±1.19)分,对照组分别为(4.74±1.64)分、(4.79±1.75)分,P=0.01;NIHSS评分:MTM组服务前后分别为(2.83±3.12)分、(1.35±1.66)分,对照组分别为(3.01±3.47)分、(2.29±3.29)分,P=0.03;ADL评分:MTM组服务前后分别为(83.48±18.35)分、(91.44±12.18)分,对照组分别为(79.85±24.12)分、(84.33±23.47)分,P=0.03。两组服务前Morisky评分、NIHSS评分、ADL评分比较差异均无统计学意义(P>0.05),服务后评分比较差异有统计学意义(P<0.05)。结论临床药师开展MTM服务,能够提高患者的依从性,对合理用药、改善患者生活方式、改善脑卒中患者的疾病预后均具有积极意义。
