Background: Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim ...Background: Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim of this study is to investigate the destructive effect of ETECT on normal rat liver. Methods: Twenty rats were randomized into 4 treatment groups (n=5 in each group): control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer. Results: We found that the destructive volumes in ETECT group were the largest (P<0.01). In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was in- creased in ECT group. Conclusion: ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.展开更多
Block copolymer polystyrene-b-poly（acrylic acid）（PS-b-PAA） was used as structural template for the synthesis of CaCO3 microparticles. Through this procedure, acid resistant hybrid CaCO3 micro- spheres were obtaine...Block copolymer polystyrene-b-poly（acrylic acid）（PS-b-PAA） was used as structural template for the synthesis of CaCO3 microparticles. Through this procedure, acid resistant hybrid CaCO3 micro- spheres were obtained. Acid resistant properties of this type of hybrid CaCO3 were studied. Size measurement shows that the acid resistant properties of the hybrid particles are different in different solutions, such as HCl, EDTA, and H2SO4 solutions.展开更多
文摘Background: Electrochemical therapy (ECT) has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle (ETN) (ETECT). The aim of this study is to investigate the destructive effect of ETECT on normal rat liver. Methods: Twenty rats were randomized into 4 treatment groups (n=5 in each group): control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer. Results: We found that the destructive volumes in ETECT group were the largest (P<0.01). In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was in- creased in ECT group. Conclusion: ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.
基金Supported by the National Natural Science Foundation of China(Nos.50803055, 30872902).
文摘Block copolymer polystyrene-b-poly（acrylic acid）（PS-b-PAA） was used as structural template for the synthesis of CaCO3 microparticles. Through this procedure, acid resistant hybrid CaCO3 micro- spheres were obtained. Acid resistant properties of this type of hybrid CaCO3 were studied. Size measurement shows that the acid resistant properties of the hybrid particles are different in different solutions, such as HCl, EDTA, and H2SO4 solutions.
